Cytoprotective Drugs and Helicobacter pylori Infection

  • M. Del Tacca
  • G. Natale
  • C. Blandizzi
Conference paper

Abstract

Cytoprotection has been defined as the ability of pharmacological agents, originally prostaglandins (PGs), to prevent or reduce gastric or intestinal mucosal injury produced by a variety of ulcerogenic and necrotizing agents, including ethanol, nonsteroidal anti inflammatory drugs (NSAIDs), steroids, bile and Helicobacter pylori (HP; Fig. 1). Gastric mucus plays an important role in maintaining or restoring gastroduodenal mucosal integrity because, other than acting as a physical barrier, mucus may create an unstirred layer of secreted bicarbonate and hence help to neutralize hydrogen ions.

Keywords

Urea Polysaccharide Bicarbonate Prostaglandin Bismuth 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • M. Del Tacca
    • 1
  • G. Natale
    • 1
  • C. Blandizzi
    • 1
  1. 1.Institute of Medical PharmacologyUniversity of PisaPisaItaly

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