Bismuth and Helicobacter pylori

  • P. Malfertheiner
  • M. Nilius
  • U. Kreusel
Conference paper


The first preparative method in making bismuth salts accessible for therapeutic purposes goes back to Georg Agricola, in the 16th century [1]. In 1786 Odier first administered “magisterium bismuti” (bismuth subnitrate) as a “safe, infallible remedy against gastric spasm”, in a dose of 24 g per day [2]. The nineteenth century brought the wide use of bismuth compounds for the treatment of syphilis. In the 1850s, treatment of dispeptic symptoms with bismuth compounds was made popular by Chambers in England and Kussmaul in Germany, administering bismuth subnitrate in doses up to 400 g [2].


Pylorus Infection Bismuth Compound Bismuth Subcitrate Colloidal Bismuth Subcitrate Bismuth Salt 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • P. Malfertheiner
    • 1
  • M. Nilius
    • 1
  • U. Kreusel
    • 2
  1. 1.Department of Internal Medicine IUniversity of UlmUlmGermany
  2. 2.Department of Inorganic ChemistryTechnical University of MunichGermany

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