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The 130-kDa Vacuolating Cytotoxin-Associated Protein Is a Component of Cytotoxic Helicobacter pylori Organisms

  • M. Bugnoli
  • D. Armellini
  • R. Rappuoli
  • A. Rossolini
  • Z. Y. Xiang
  • N. Figura
Conference paper

Abstract

Helicobacter pylori (HP) is the agent of type B gastritis and a cofactor in the development of peptic ulcer and probably also of gastric cancer. Certain HP strains produce a toxin which induces intracellular vacuolization on mammalian cells in vitro. Proteins associated with vacuolating activity (VA) have molecular weights of 130, 95, and 80 kDa and can be detected broth and in concentrated broth culture filtrates (CBCF) of cytotoxic strains [1].

Keywords

Peptic Ulcer Duodenal Ulcer Helieobaeter Pylorus Acridine Orange Dyspeptic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Figura N, Bugnoli M, Cusi MG, Pucci AM, Lusini P, Quaranta S, Barberi A, Rossolini A, Di Tommaso AL, De Magistris T, Rappuoli R, Marri L, Musmanno RA, Russi M, Guarna M, Losi M (1990) Pathogenic mechanisms of Helicobacter pylori: production of cytotoxin. In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, p 86CrossRefGoogle Scholar
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    Figura N, Bugnoli M, Guglielmetti P, Musmanno RA, Russi M, Quaranta S (1990) Antibodies to vacuolating toxin of Helicobacter pylori in dyspeptic patients. Rev Esp Enferm Dig 78 (S I): 7Google Scholar
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    Figura N, Guglielmetti P, Rossolini A, Barberi A, Cusi G, Musmanno RA, Russi M, Quaranta S (1989) Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 27:225–226PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • M. Bugnoli
    • 1
  • D. Armellini
    • 1
  • R. Rappuoli
    • 1
  • A. Rossolini
    • 2
  • Z. Y. Xiang
    • 3
  • N. Figura
    • 2
  1. 1.Sclavo Research CenterSienaItaly
  2. 2.Istituto di Malattie InfettiveUniversità di SienaItaly
  3. 3.Shanghai HospitalShanghaiChina

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