The Value of Class and Subclass ELISAs and Antibody Specificity in Monitoring Treatment of Helicobacter pylori

  • A. R. Stacey
  • G. D. Bell
  • D. G. Newell


Serology has been proposed as a non-invasive test for the monitoring of treatment to eradicate Helicobacter pylori infection. However, the total IgG response associated with this chronic mucosal infection is generally long lived. Preliminary data [3] suggested that certain IgG subclasses had I shorter life and were better indicators of successful treatment. Moreover, some antigens would be expected preferentially to induce antibody responses with shorter half-hves. Therefore the persistence of patient serum anti-H. pylori class and subclass responses was investigated in sequential samples from both successfully and unsuccessfully treated patients followed over a 12-month period. In addition, the antigen specificity of these antibodies was studied using wastern blotting techniques.


Pylorus Antibody Total Immunoglobulin Molecular Weight Polypeptide Abede Abede Abede Induce Antibody Response 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. R. Stacey
    • 1
  • G. D. Bell
    • 2
  • D. G. Newell
    • 3
  1. 1.PHLS Centre for Applied Microbiology and ResearchPorton Down, SalisburyUK
  2. 2.Department of MedicineIpswich HospitalIpswichUK
  3. 3.Central Veterinary LaboratoryWeybridgeUK

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