The Value of Class and Subclass ELISAs and Antibody Specificity in Monitoring Treatment of Helicobacter pylori
Serology has been proposed as a non-invasive test for the monitoring of treatment to eradicate Helicobacter pylori infection. However, the total IgG response associated with this chronic mucosal infection is generally long lived. Preliminary data  suggested that certain IgG subclasses had I shorter life and were better indicators of successful treatment. Moreover, some antigens would be expected preferentially to induce antibody responses with shorter half-hves. Therefore the persistence of patient serum anti-H. pylori class and subclass responses was investigated in sequential samples from both successfully and unsuccessfully treated patients followed over a 12-month period. In addition, the antigen specificity of these antibodies was studied using wastern blotting techniques.
KeywordsUrea Polypeptide Catalase Gastritis Sera
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