Haemagglutinins of Helicobacter pylori and Adherence to HEp-2 Cells

  • C. S. Goodwin


Adherence to surface receptors is an essential step in pathogenesis for many bacteria. Attachment is mediated by adhesions or ligands which may be soluble or cell-associated, and which can be demonstrated by haemagglutination of various species of erythrocyte. Mannose-resistant haemagglutination by H. pylori has been described by Evans et al. [3] and others [2, 4]. However, these reports disagree on the properties of the haemagglutinins. Furthermore, different workers have used different methods of testing for HA; Evans et al. used slide haemagglutination [3], but Huang et al. used a micro-titre method [4]. It is probable that some of these differences are explained by the presence of different adhesins so that more than one type of receptor is involved.


Sialic Acid Haemagglutinating Activity Bovine Submaxillary Mucin Colonization Factor Antigen Stomach Antrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Armstrong JA, Cooper M, Goodwin CS et al. (1991) Influence of soluble haemagglutinins on adherence of Helicobacter pylori to HEp-2 cells. J Med Microbiol 34:181–187PubMedCrossRefGoogle Scholar
  2. 2.
    Emödy L, Carlsson Â, Ljungh  et al. (1988) Mannose-resistant haemagglutination by Campylobacter pylori. Scand J Infect Dis 20:353–354PubMedCrossRefGoogle Scholar
  3. 3.
    Evans DG, Evans DJ, Moulds JJ et al. (1988) N-Acetylneuraminyllactose-binding fibrillar haemagglutinin of Campylobacter pylori: a putative colonization factor antigen. Infect Immun 56:2896–2906PubMedGoogle Scholar
  4. 4.
    Huang J, Smyth CH, Kennedy NP et al. (1988) Haemagglutinating activity of Campylobacter pylori. FEMS Microbiol Lett 56:109–112CrossRefGoogle Scholar
  5. 5.
    Krivan HC, Nilsson B, Lingwood CA et al. (1991)Chlamydia trachomatis and Chlamydia pneumoniae bind specifically to phosphatidyelethanolamine in HeLa cells and to GalNAc beta l-4Gal beta 1–4GLC sequences found in asialo-GMl and asial-GM2. Biochem Biophys Res Commun 175:108–109CrossRefGoogle Scholar
  6. 6.
    Lingwood CA, Woods DE, Krivan HC (1991) Helicobacter pylori: its lipid receptors and adhesin. Microb Ecol Health Dis 4 (Special Issue): S123Google Scholar
  7. 7.
    Robinson J, Goodwin CS, Cooper M et al. (1990) Soluble and cell-associated haemagglutinis of Helicobacter (Campylobacter) pylori. J Med Microbiol 33:277–284PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. S. Goodwin
    • 1
  1. 1.Department of Medical Microbiology, Faculty of Medicine and Health ScienceUnited Arab Emirates UniversityAl AinUnited Arab Emirates

Personalised recommendations