Construction of a Molecular Population Genetic Framework for the Characterization of Helicobacter pylori Pathogenesis by Multilocus Enzyme Electrophoresis
Helicobacter pylori is now recognized as the most common cause of gastritis. H. pylori has also been implicated in the pathogenesis of duodenal ulcer disease and gastric ulcer disease and may play an important role in the development of precursor lesions of gastric cancer. It remains unclear whether the differences in the presentation of H. pylori associated diseases are due to infection with different genetic strains of H. pylori, variation in the host response, or both. Studies attempting to identify H. pylori strains associated with specific H. pylori diseases have recently begun (e.g., chromosomal and plasmid DNA restriction endonuclease profiling analyses). DNA-DNA solution hybridization of genomic DNA from H. pylori isolates found that H. pylori isolates from patients with duodenal ulcer, on average, formed a different hybridization group from isolates from patients with asymptomatic gastritis . Recent studies of many other pathogenic bacterial species have shown that genetic subpopulations of bacteria are nonrandomly associated with certain clinical disorders  and that, even for species that are genetically highly variable, the majority of cases of serious disease are caused by a small proportion of the total bacterial cell lineages.
KeywordsDuodenal Ulcer Adenylate Kinase Pylorus Strain Enzyme Locus Hybridization Group
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