Skip to main content
Book cover

Amlodipine pp 111–130Cite as

Calcium Antagonism and the Ischaemic Heart: Is Calcium Antagonism Relevant?

  • Chapter
  • 93 Accesses

Abstract

Having established that the calcium antagonists, including vascular selective calcium antagonists such as amlodipine, have a favourable effect on renal haemodynamics and function (Chapter 10), and before considering their usefulness as blood pressure lowering agents — particularly with respect to their long term use in the management of patients with essential hypertension (Chapter 14), the logical question which emerges now concerns the feasibility of using calcium antagonists to protect the ischaemic myocardium. The next three chapters (Chapters 11–13) and Chapter 16 address this problem. Firstly, however, it is necessary to consider the laboratory data which indicates that these drugs can protect against the consequences of artificially-induced ischaemia. Only then is it relevant to consider the available data pursuant to the use of these drugs in the management of patients with naturally-occurring ischaemic heart disease. There are two major reasons why discussion on this topic should be included here, even though the clinical management of patients with ischaemic heart disease is currently undergoing massive changes in strategy, with new “protective” regimes being devised and new criteria for diagnosis being developed.

Keywords

  • Calcium Antagonist
  • Ischaemic Heart Disease
  • Adenosine Triphosphate
  • Ischaemic Myocardium
  • Beta Adrenoceptor Antagonist

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

“To be or not to be — that is the question.”

William Shakespeare in “Hamlet”

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-78223-7_11
  • Chapter length: 20 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-78223-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   139.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Nayler, W.G. (1993). Calcium Antagonism and the Ischaemic Heart: Is Calcium Antagonism Relevant?. In: Amlodipine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78223-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78223-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56698-4

  • Online ISBN: 978-3-642-78223-7

  • eBook Packages: Springer Book Archive