Abstract
Based on the classical endocrine model of IGF-I to act on target cells after being secreted into the circulation, liver seems to be the organ responsible for such mode of action. A support for this hypothesis is that liver accounts for most of the circulating IGF-I (Schwander et al. 1983) and that it is insensitive to its action. At variance with EGF, IGF-I is unable to stimulate thymidine incorporation on isolated adult rat hepatocytes in culture, but it maintains the capacity to stimulating leucine incorporation, an action which mirrors its metabolic effect (Barreca et al. 1992b). Since it is believed that the metabolic effects of IGFs are exerted through the insulin receptors, these data are in agreement with the findings that hepatocytes are devoid of IGF-I receptors (Caro et al. 1988). If the liver is the major producer of IGF-I, the lack of IGF-I mitogenic effect on hepatocytes is a support for the endocrine hypothesis of IGF-I mode of action.
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References
Barreca A, Minuto F, Voipe A, Cecchelli E, Cella F, Del Monte P, Artini P, Giordano G (1990) Insulin-like growth factor-I (IGF-I) and IGF-I binding protein in the follicular fluids of growth hormone treated patients. Clin Endocrinol 32:497.
Barreca A, De Luca M, Del Monte P, Bondanza S, Damonte G, Cariola G, Di Marco E, Giordano G, Cancedda R, Minuto F (1992a) In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors. J Cell Physiol 151:262–268.
Barreca A, Voci A, Minuto F, De Marchis M, Cecchelli E, Fugassa E, Giordano G, Gallo G (1992b) Effect of epidermal growth factor on insulin-like growth factor-I (IGF-I) and IGF-binding protein synthesis by adult rat hepatocytes. Mol Cell Endocrinol 84:119–126.
Barreca A, Artini PG, Del Monte P, Ponzani P, Pasquini P, Cariola G, Volpe A, Genazzani AR, Giordano G, Minuto F In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells. J Clin Endocrinol Metal (in press).
Barreca A, Minuto F, Giordano G Growth factor production by human ovary. Proceedings of the 2nd international Capri conference on neuroendocrine disorders of female reproductive system: pathophysiology and therapies Partenon, Park Ridge (in press).
Baxter RC (1988) Characterization of the acid-labile subunit of the growth hormone dependent insulin-like growth factor binding protein complex. J Clin Endocrinol Metab 67:265–272.
Caro JF, Poulos J, Ittoop O, Pories WJ, Flickinger EG, Sinha M (1988) Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver. J Clin Invest 81:976–981.
D’Ercole AJ, Applewhite GT, Underwood LE (1980) Evidence that somatomedin is synthesized by multiple tissues in the fetus. Dev Biol 75:315–328.
D’Ercole AJ, Stiles AD, Underwood LE (1984) Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 81:935–939.
Furlanetto RW (1980) The somatomedin C binding protein: evidence for a heterologous subunit structure. J Clin Endocrinol Metab 51:12–19.
Geistovel F, Moretti-Rojas I, Asch RH, Rojas FJ (1989) Expression of insulin-like growth factor-II (IGF-II) messenger ribonucleic acid (mRNA), but not IGF-I mRNA in human preovulatory granulosa cells. Hum Reprod 4:899–902.
Green H (1980) The keratinocyte as differentiated cell type. Harvey Lect 74:101–139.
Green H, Morikawa N, Nixon T (1985) A dual effector theory of growth hormone action. Differentiation 29:195–198.
Hernandez ER, Hurwitz A, Vera A, Pellicer A, Adashi EY, LeRoith D, Roberts CT (1992) Expression of the genes encoding the insulin-like growth factors and their receptors in human ovary. J Clin Endocrinol Metab 74:419–425.
Lindahl A, Nilsson A, Isaksson OGP (1987) Effects of growth hormone and insulin-like growth factor-I on colony formation of rabbit epiphyseal chondrocytes at different stages of maturation. J Endocrimol 115:263–271.
Minuto F, Del Monte P, Barreca A, Fortini P, Cariola G, Catrambone G, Giordano G (1986) Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors. Cancer Res 46:985–988.
Minuto F, Del Monte P, Barreca A, Nicolin A, Giordano G (1987) Partial characterization of somatomedin C-like immunoreactivity secreted by breast cancer cells in vitro. Mol Cell Endocrinol 54:179–184.
Minuto F, Del Monte P, Barreca A, Alama A, Cariola G, Giordano G (1988) Evidence for autocrine mitogenic stimulation by somatomedin-C/insulin-like growth factor I on an established human lung cancer cell line. Cancer Res 48:3716–3719.
Minuto F, Barreca A, Del Monte P, Cariola G, Torre GC, Giordano G (1989) Immunoreactive insulin-like growth factor I (IGF-I) and IGF-I binding protein content in human thyroid tissue. J Clin Endocrinol Metab 68:621–626.
Minuto F, Barreca A, Del Monte P, Giordano G (1991) Paracrine actions of IGF binding proteins. Acta Endocrinol (Copenh) 124:63–69.
Schwander JC, Hauri C, Zapf J, Froesch ER (1983) Synthesis and secretion of insulin-like growth factor and its binding protein by perfused rat liver: dependence on growth hormone status. Endocrinology 113:297–305.
Sporn MB, Roberts AB (1985) Autocrine growth factors and cancer. Nature 313:745–747.
Tramontano D, Cushing GW, Moses AC, Ingbar SH (1986) Insulin-like growth factor-I stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis induced by TSH and Graves’-IgG. Endocrinology 119:940–942.
Volpe A, Coukos G, Barreca A, Artini PG, Minuto F, Giordano G, Genazzani AR (1989) Ovarian response to combined growth hormone-gonadotropin treatment in patients resistant to induction of superovulation. Gynecol Endocrinol 3:125.
Zezulak KM, Green H (1986) The generation of insulin-like growth factor I sensitive cells by growth hormone action. Science 233:551–553.
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© 1993 Springer-Verlag Berlin Heidelberg
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Minuto, F., Barreca, A., Giordano, G. (1993). Autocrine and Paracrine Effects of Insulin-like Growth Factors and Their Binding Proteins. In: Müller, E.E., Cocchi, D., Locatelli, V. (eds) Growth Hormone and Somatomedins during Lifespan. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78217-6_11
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DOI: https://doi.org/10.1007/978-3-642-78217-6_11
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