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Protection of Functional Groups

  • Miklos Bodanszky

Abstract

While it is necessary to mask the amino function of an amino acid or peptide during activation of the carboxyl group which participates in the subsequent coupling, it is equally important to select protecting groups that can readily be removed. Otherwise the integrity of the already formed peptide bonds would be endangered. If the peptide obtained in a coupling reaction has to be lengthened at its N-terminus, then an additional requirement limits the choice of the amine-blocking group: it must be removable under conditions which leave the masking of the carboxyl group and the protection of side chain functions intact. Thus, blocking of the α-amino function is generally transient while that of all other functions mostly semipermanent.

Keywords

Blocking Group Benzyl Bromide Benzyl Ester Benzyl Cation Histidine Side Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Additional Sources

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Miklos Bodanszky
    • 1
  1. 1.PrincetonUSA

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