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Environmental Carcinogens: Assessment of Exposure and Effect

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Book cover Indoor and Outdoor Air Pollution and Human Cancer

Part of the book series: Monographs ((ESO MONOGRAPHS))

Abstract

In the previous monograph the chapter on exposure monitoring covered air and biological sampling [1]. An analysis was given of parent compounds and, in the case of biological monitoring, of their metabolites in the body. In the present chapter we discuss a new form of biological monitoring: measurement of covalent reaction products (adducts) of the carcinogen with DNA and protein. In addition, we discuss the consequences of the adducts, i.e., mutations. The examples are taken from environmental exposures.

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Author information

Authors and Affiliations

  1. Centre for Nutrition and Toxicology, Karolinska Institute, Novum, 141 57, Huddinge, Sweden

    Kari Hemminki

  2. Steno Institute of Public Health, University of Aarhus, 8000, Aarhus, Denmark

    Herman Autrup

  3. National Institute of Occupational Health, 8149 Dep, 0033, Oslo, Norway

    Aage Haugen

Authors
  1. Kari Hemminki
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  2. Herman Autrup
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  3. Aage Haugen
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Editors and Affiliations

  1. International Agency for Research on Cancer, 150, cours Albert-Thomas, 69372, Lyon Cedex 08, France

    Lorenzo Tomatis

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© 1993 Springer-Verlag Berlin Heidelberg

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Hemminki, K., Autrup, H., Haugen, A. (1993). Environmental Carcinogens: Assessment of Exposure and Effect. In: Tomatis, L. (eds) Indoor and Outdoor Air Pollution and Human Cancer. Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78197-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-78197-1_5

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