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Mechanisms of Thermal Radiosensitization Studied in CHO Cells

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Advances in Mutagenesis Research

Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 5))

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Abstract

Inactivation of mammalian cells by ionizing radiation is caused by damage induced in the DNA (Marin and Bender 1963a,b; Burki and Okada 1970; Munro 1970). Among the various types of damage induced in DNA, double-strand breaks and probably also base damage are considered important, whereas single-strand breaks are much less relevant for cell killing (Ward 1985, 1986; Frankenberg-Schwager 1989). It is generally assumed that a certain portion of the primary lesions cannot be repaired and give rise to chromosomal aberrations that finally lead to cell death (Hopwood and Tolmach 1979).

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Authors and Affiliations

  1. Institute of Biophysics and Radiobiology, University of Hamburg, Martinistr. 52, 20251, Hamburg, Germany

    E. Dikomey

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  1. E. Dikomey
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  1. FB9 der Universität Gesamthochschule Essen, Universitätsstraße 5, Postfach 45037, 45117, Essen, Germany

    Günter Obe

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© 1994 Springer-Verlag Berlin Heidelberg

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Dikomey, E. (1994). Mechanisms of Thermal Radiosensitization Studied in CHO Cells. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78193-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-78193-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78195-7

  • Online ISBN: 978-3-642-78193-3

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