Basis for Antibacterial Treatment of Prostatitis: Experimental and Clinical Pharmacokinetic Studies and Models
Great effort has been invested in the treatment of chronic bacterial prostatitis, but with rather disappointing results. The best cure rates reported using trimethoprim-sulfamethoxazole and various quinolones for 4 weeks-30 months vary from 32% to 71% (Meares 1975; Andriole 1991; McGuire and Lytton 1976; Weidner et al. 1991; Paulson and DeVere White 1978). The disappointing results are probably due to poor drug penetration into the prostate (Stamey et al. 1970; Aagaard and Madsen 1991; Meares 1992). To study the principles contributing to drug penetration into the various prostatic compartments, several animal models (dogs and rats) have been used. The results should, however, be interpreted with caution before being applied clinically. Some drug penetration studies have been carried out in patients undergoing transurethral prostatic surgery, but these studies involved mainly the hypertrophied prostate, not the normal and rarely the chronically infected prostate.
KeywordsAmpicillin Erythromycin Doxycycline Fluoroquinolones Aminoglycosides
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