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Trophic Effects of Gastrin: Therapeutic and Pathophysiological Implications

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The Stomach

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Abstract

Gastrin is an important regulator of gastric acid secretion. In addition, it exerts well-defined trophic effects on the gastrointestinal tract which have long been linked to the pathogenesis of peptic ulcer disease [1, 2]. Moreover, hyper- gastrinaemia occurring during ulcer treatment with acid inhibitors is considered by many to be a risk factor fostering early ulcer relapse and development of malignant gastric tumours [for references see [3]]. Conversely, it has been postulated that as a growth factor gastrin could, in a manner analogous to epidermal growth factor, enhance re epithelialization of ulcers and possibly act as a mucosal protective factor [3].

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Authors
  1. F. Halter
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  2. A. Schmassmann
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Editors and Affiliations

  1. University of Münster, Albert-Schweitzer-Str. 33, D-48149, Münster, Germany

    W. Domschke MD MD(hon) FACG (Chairman of the Department of Medicine B) (Chairman of the Department of Medicine B)

  2. University of Kraków, ul. Grzegórzecka 16, PL-31531, Kraków, Poland

    S. J. Konturek MD (Chairman of the Institute of Physiology) (Chairman of the Institute of Physiology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Halter, F., Schmassmann, A. (1993). Trophic Effects of Gastrin: Therapeutic and Pathophysiological Implications. In: Domschke, W., Konturek, S.J. (eds) The Stomach. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78176-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-78176-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56613-7

  • Online ISBN: 978-3-642-78176-6

  • eBook Packages: Springer Book Archive

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