The Stomach pp 58-67 | Cite as

Trophic Effects of Gastrin: Therapeutic and Pathophysiological Implications

  • F. Halter
  • A. Schmassmann
Conference paper


Gastrin is an important regulator of gastric acid secretion. In addition, it exerts well-defined trophic effects on the gastrointestinal tract which have long been linked to the pathogenesis of peptic ulcer disease [1, 2]. Moreover, hyper- gastrinaemia occurring during ulcer treatment with acid inhibitors is considered by many to be a risk factor fostering early ulcer relapse and development of malignant gastric tumours [for references see [3]]. Conversely, it has been postulated that as a growth factor gastrin could, in a manner analogous to epidermal growth factor, enhance re epithelialization of ulcers and possibly act as a mucosal protective factor [3].


Acid Secretion Peptic Ulcer Disease Parietal Cell Trophic Effect Plasma Gastrin 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • F. Halter
  • A. Schmassmann

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