Skip to main content
SpringerLink
Log in

Rational Long-Term Therapy of Peptic Ulcer Disease

  • Conference paper
Book cover The Stomach

  • 147 Accesses

Abstract

Peptic ulcer is a chronic disease characterized by spontaneous remissions and relapses which may lead to potentially lethal complications such as hemorrhage and perforation. The duration of this relapsing tendency is unpredictable in any individual patient but may last for many years, if not the entire lifetime, thus making a long-term treatment strategy a necessity. In recent years, various therapeutic opinions to maintain the disease in remission have become available, each one with a number of advantages and disadvantages. The present paper aims to review the different therapeutic options for the long-term management of peptic ulcer disease, with particular reference to their ability to prevent recurrences and complications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bardhan KD (1988) Six years of continuous cimetidine treatment in peptic ulcer disease: efficacy and safety. Aliment Pharmacol Therap 2: 395–405

    Article  CAS  Google Scholar 

  2. Bardhan KD (1988) Intermittent treatment of duodenal ulcer for long-term medical management: a review. Postgrad Med J 64 (Suppl. 1): 40–46

    PubMed  Google Scholar 

  3. Bardhan KD, Cole DS, Hawkins BW, Franks CR (1982) Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Brit Med J 284: 621–624

    Article  CAS  Google Scholar 

  4. Bayerdòrffer E, Mannes GA, Sommer A et al. (1992) High-dose omeprazole treatment combined with amoxicillin eradicates Helicobacter pylori. Eur J Hepatol Gastroenterol, 1992, 4, 697–702

    Google Scholar 

  5. Bianchi Porro G (1985) Symposium proceedings. XII International Congress of Gastroenterology, Lisbon, pp. 33–38, Universitetsforlaget, Oslo, 1985

    Google Scholar 

  6. Bianchi Porro G, Parente F (1991) Long-term treatment of duodenal ulcer. A review of management options. Drugs 1991; 41: 38–51

    Article  Google Scholar 

  7. Bianchi Porro G, Petrillo M, Lazzaroni M, Sangaletti O (1982) The longer-term treatment of duodenal ulceration with cimetidine. In Bianchi Porro & Bardhan (Eds) Peptic ulcer disease: advances in pathogenesis and treatment, pp. 107–113, Cortina International, Verona, 1982

    Google Scholar 

  8. Bianchi Porro G, Boiling E, Barbara L et al. (1990) Maintenance treatment with omeprazole in the prevention of duodenal ulcer relapse: a double-blind comparative trial. Digestive Disease Week, S. Antonio, May 13–16, 1990, 213-A

    Google Scholar 

  9. Blasi A, Magiameli A, Castelli G et al. (1987) Long-term (24 month) ranitidine in prevention of duodenal ulcer relapse: comparison of continuous and seasonal treatment. Ital J Gastroenterol 19: 141–144

    Google Scholar 

  10. Dobrilla G, Vallaperta P, Amplatz S (1988) Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials. Gut 29: 181–187

    Article  PubMed  CAS  Google Scholar 

  11. Fry J (1964). Peptic ulcer: a profile. Br Med J 2: 808–812

    Article  Google Scholar 

  12. George L, Hyland L, Morgan A et al. (1990) Smoking does not contribute to duodenal ulcer relapse after eradication. Gastroenterology 98: A48 (Abstract.)

    Google Scholar 

  13. Greibe J, Bugge P, Gjorup T, Lauritsen T, Bonnevie O, Wulff HR (1977) Long-term prognosis of duodenal ulcer; follow-up study and survey of doctor’s estimates. Br Med J 2: 1572–1574

    Article  PubMed  CAS  Google Scholar 

  14. Gustavsson S, Holmberg L, Nyren O, Dhrvall U, Wells L (1990) Risk of serious complications in patients with duodenal or prepyloric ulcers, Gastroenterology 98, 54A

    Google Scholar 

  15. Heatley RV (1992) Review article: the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther 6: 291–303

    Article  PubMed  CAS  Google Scholar 

  16. Krag E (1966) Long-term prognosis in medically treated peptic ulcer. Acta Med. Scand 180, 657–668

    Article  PubMed  CAS  Google Scholar 

  17. Krause U (1963) Long-term results of medical and surgical treatment of peptic ulcer. Acta Chir Scand 125 (Suppl. 310): 5–111

    Google Scholar 

  18. Kurata JH, Koch GG, Nogawa AN (1987) Comparison of ranitidine and cimetidine ulcer maintenance therapy. J Clin Gastroenterol 9: 644–650

    Article  PubMed  CAS  Google Scholar 

  19. Lane MR, Lee SP (1988) Recurrence of duodenal ulcer after medical treatment. Lancet 1: 1147–1149

    Article  PubMed  CAS  Google Scholar 

  20. Lauritsen K, Andersen BN, Laurse LS et al. (1991) Omeprazole 20 mg three days a week and 10 mg daily in the prevention of duodenal ulcer relapse. Double-blind comparative trial. Gastroenterology 100: 663–669

    PubMed  CAS  Google Scholar 

  21. Martin L, Lewis N (1949) Peptic ulcer cases reviewed after 10 years. Lancet ii: 1115–1120

    Article  Google Scholar 

  22. Penston J, Wormsley KG (1989) Efficacy and safety of long-term maintenance therapy of duodenal ulcers. Scand J Gasterentol 24: 1145–1152

    Article  CAS  Google Scholar 

  23. Penston JG, Wormsley KG (1990) Long-term maintenance treatment of gastric ulcers with ranitidine. Aliment Pharmacol Therap 4: 339–355

    Article  CAS  Google Scholar 

  24. Penston JG, Wormsley KG (1992) Review article: maintenance treatment with H2-receptor antagonists for peptic ulcer disease. Aliment Pharmacol Therap 6: 3–29

    Article  CAS  Google Scholar 

  25. Pulvertaft CN (1968) Incidence of natural history of gastric and duodenal ulcer. Postgrad Med J 44: 597–602

    Article  PubMed  CAS  Google Scholar 

  26. Susi D, Ianetti G, Di Pietro AM (1987) Long-term therapy of peptic ulcer: our experience with ranitidine after 4 years. Ital J Gastroenterol 19: 69S

    Google Scholar 

  27. Tytgat GNJ, Noach LA, Rauws E (1992) Helicobacter pylori. Eur J Gastroenterol Hepatol 4 (suppl. 1): 57–515

    Google Scholar 

  28. Unge P, Eriksson K, Bergman B et al. (1992) Omeprazole and amoxicillin in patients with duodenal ulcer: helicobacter pylori eradication and remission of ulcers and symptoms during a 6-month follow-up. Digestive Disease Week, S. Francisco, May 10–13, 1992, A163

    Google Scholar 

  29. Viskum A (1976) A comparison of the course of the disease among patients with gastric ulcer, duodenal ulcer, and ulcer dyspepsia without ulcer demonstrable by X-ray. Dan Med Bull 23: 129–136

    PubMed  CAS  Google Scholar 

  30. Walan A, Bianchi Porro G, Hentschel E, Bardhan KD, Delattre M. Maintenance treatment with cimetidine in peptic ulcer disease for up to 4 years. Scand J Gastroenterol 1987; 22: 397–405

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. G. Bianchi Porro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Parente
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Münster, Albert-Schweitzer-Str. 33, D-48149, Münster, Germany

    W. Domschke MD MD(hon) FACG (Chairman of the Department of Medicine B) (Chairman of the Department of Medicine B)

  2. University of Kraków, ul. Grzegórzecka 16, PL-31531, Kraków, Poland

    S. J. Konturek MD (Chairman of the Institute of Physiology) (Chairman of the Institute of Physiology)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bianchi Porro, G., Parente, F. (1993). Rational Long-Term Therapy of Peptic Ulcer Disease. In: Domschke, W., Konturek, S.J. (eds) The Stomach. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78176-6_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78176-6_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56613-7

  • Online ISBN: 978-3-642-78176-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation