The Stomach pp 22-37 | Cite as

Structural and Functional Significance of the Gastric H+, K+-ATPase

  • J. G. Forte
  • D. C. Chow

Abstract

The apical plasma membrane of gastric parietal cells is highly adapted to perform its major physiological role in the secretion of concentrated HCl and at the same time maintain a resistance against the caustic degeneration from its very acidic secretory product. The predominant protein in the apical membrane of the secreting parietal cell is the proton pump protein, the H+, K+-ATPase. This membrane protein not only functions as the primary force for generation of HC1 secretion, but must also be endowed with special properties that make it insensitive to pepsinolysis and H+ degradation.

Keywords

Carbohydrate Cysteine Oligomer Disulfide Oligo Saccharide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. G. Forte
  • D. C. Chow

There are no affiliations available

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