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Structural and Functional Significance of the Gastric H+, K+-ATPase

  • Conference paper
The Stomach

Abstract

The apical plasma membrane of gastric parietal cells is highly adapted to perform its major physiological role in the secretion of concentrated HCl and at the same time maintain a resistance against the caustic degeneration from its very acidic secretory product. The predominant protein in the apical membrane of the secreting parietal cell is the proton pump protein, the H+, K+-ATPase. This membrane protein not only functions as the primary force for generation of HC1 secretion, but must also be endowed with special properties that make it insensitive to pepsinolysis and H+ degradation.

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© 1993 Springer-Verlag Berlin Heidelberg

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Forte, J.G., Chow, D.C. (1993). Structural and Functional Significance of the Gastric H+, K+-ATPase. In: Domschke, W., Konturek, S.J. (eds) The Stomach. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78176-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-78176-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56613-7

  • Online ISBN: 978-3-642-78176-6

  • eBook Packages: Springer Book Archive

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