The Stomach pp 22-37 | Cite as

Structural and Functional Significance of the Gastric H+, K+-ATPase

  • J. G. Forte
  • D. C. Chow


The apical plasma membrane of gastric parietal cells is highly adapted to perform its major physiological role in the secretion of concentrated HCl and at the same time maintain a resistance against the caustic degeneration from its very acidic secretory product. The predominant protein in the apical membrane of the secreting parietal cell is the proton pump protein, the H+, K+-ATPase. This membrane protein not only functions as the primary force for generation of HC1 secretion, but must also be endowed with special properties that make it insensitive to pepsinolysis and H+ degradation.


Disulfide Bond Gastric Parietal Cell Helix Pomatia Agglutinin Carbohydrate Side Chain Ouabain Binding Site 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. G. Forte
  • D. C. Chow

There are no affiliations available

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