Zusammenfassung
Obwohl weltweit Übereinstimmung besteht, daß die Exzision weit im Gesunden Therapie der Wahl bei Patienten mit malignen Melanom der Haut ist, werden das primäre Vorgehen, die Größe des Sicherheitsabstandes, die prophylaktische Lymphknotenausräumung, die hypertherme Extremitätenperfusion und eine adjuvante Therapie im Stadium I immer noch kontrovers diskutiert.
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Literatur
Braun-Falco O, Landthaler M, Holzel D, Konz B, Schmoeckel C (1986) Therapie und Prognose maligner Melanome der Haut. Dtsch Med Wschr 111: 1750–1756
Crowley NJ, Seigier HE (1990) Th role of elective lymphnode dissection in the management of patients with thick cutaneous melanoma. Cancer 66: 2522–2527
Drepper H, Bieß B, Bröcker EB, Klein HM, Lippold A,Macher E, Peters A (1990) Ergeb-nisse einer vergleichenden Studie zur elektiven Lymphknotendissektion. In: Orfanos CE, Garbe C (Hrsg) Das maligne Melanom der Haut. Zuckschwerdt, München Bern Wien San Francisco SS 214–221
Drzewiecki KT, Ladefoged C, Christensen HE (1980): Biopsy and prognosis for cutaneous malignant melanomas in clinical stage I. Scand J Plast Reconstr Surg 14: 141–144
Eldh J (1979) Excisional biopsy and delayed wide excision versus primary wide excision of malignant melanoma. Scand J Plast Reconstr Surg 13: 341–345
Epstein E, Bragg K, Linden G (1969) Biopsy and prognosis of malignant melanoma. J Am Med Assoc 208: 1369–1371
Esch van der EP, Rampen FHJ (1985) Punch biopsy of melanoma. J Am Acad Dermatol 13: 899–902
Evans J, McCann G (1990) A new protocol for the treatment of stage I cutaneous malignant melanoma; interim results of the first 806 patients treated. Br J Plast Surg 43: 426–430
Ghussen F, Krüger I, Groth W, Stützer H (1988) The role of regional hyperthermic cytostatic perfusion in the extremity melanoma. Cancer 61: 654–659
Griffiths RW, Briggs JC (1985) Biopsy procedures, primary wide excisional surgery and long term prognosis in primary clinical stage I invasive cutaneous malignant melanoma. Ann R Coll Surg Engl 67: 75–78
KrementzET, MuchmoreJH, Carter RD, Sutherland CM (1988) Regional chemotherapy for melanoma of the limbs. Contr Oncol 29: 247–260
Landthaler M, Braun-Falco O, Leitl A, Konz B, Holzel D (1989) Excisional biopsy as the first therapeutic procedure versus primary wide excision of malignant melanoma. Cancer 64: 1612–1616
Landthaler M, Braun-Falco O (1989) Zur Therapie des malignen Melanoms im Stadium I. — Offene Fragen und Empfehlungen. Onkologie 12: 269–272
Landthaler M, Braun-Falco O, Holzel D, Konz B, Schubert-Fritschle G (1990) Der Sicherheitsabstand bei der primären operativen Versorgung des malignen Melanoms. In: Orfanos CE, Garbe C (Hrsg) Das maligne Melanom der Haut. Zuckschwerdt, München Bern Wien San Francisco, SS 209–213
Ledermann JS, Sober A J (1985) Does biopsy type influence survival in clinical stage I cutaneous melanoma? J Am Acad Dermatol 13: 983–987
Ledermann JS, Sober AJ (1986) Does wide excision as the initial diagnostic procedure improve prognosis in patients with cutaneous melanoma? J Dermatol Surg Oncol 12:697– 699
Lees VC, Briggs JC (1991) Effect of initial biopsy procedure on prognosis in stage I invasive cutaneous malignant melanoma: review of 1086 patients. Br J Surg 78: 1108–1110
McCarthy WH, Shaw HM, Milton GW (1985) Efficacy of elective node dissection in 2347 patients with clinical stage I malignant melanoma. Surg Gynecol Obstet 161: 575–580
Milton GW, Shaw HM, McCarthy WH, Pearson L, Balch CM, Soong SJ (1982) Prophylactic lymph node dissection in clinical stage I cutaneous malignant melanoma: Results of surgical treatment in 1319 patients. Br Jr Surg 69
Rampen FHJ, van Houten WA, Hop WCJ (1980) Incisional procedures and prognosis in malignant melanoma. Clin Exp Dermatol 15: 313–320
Rampen FHJ, Spronk CA (1983) How “fine” is incisional biopsy of melanoma. Ann Plast Surg 16: 173–174
Reintgen DS, Cox EB, McCarthy KS et al. (1983) Efficacy of elective lymph node dissection in patients with intermediate thickness primary melanoma. Ann Surg 200: 769–775
Schmoeckel C, Bockelbrink A, Bockelbrink H, Kistler H, Braun-Falco O (1983) Low- and high-risk malignant melanoma - III. Prognostic significance of the resection margin. Eur J Cancer Clin Oncol 19: 245–249
Seebacher C, Heubaum F, Küster P, SteinertW, Koch R (1990) Vergleichende Analyse in Narkose und Lokalanästhesie operierter maligner Melanome der Haut. Hautarzt 41:137– 141
Sim FH, Taylor WF, Pritchard DJ et al. (1986) Lymphadenectomy in management of stage I malignant melanoma: A prospective randomized study. Mayo Clin Proc 61: 697–705
Veronesi U, Adamus J, Bandiera DC et al. (1982) Delayed regional lymph node dissection in stage I melanoma of the skin of the lower extremities. Cancer 49: 2420–2430
Veronesi U, Adamus J, Aubert C et al. (1982) A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma. N Engl J Med 307: 913–916
Veronesi U, Cascinelli N (1991) Narrow excision (1–cm margin). A safe procedure for thin cutaneous melanoma. Arch Surg 126: 438–441
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Landthaler, M. (1993). Radikalität in der Behandlung maligner Melanome. In: Braun-Falco, O., Plewig, G., Meurer, M. (eds) Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78163-6_22
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DOI: https://doi.org/10.1007/978-3-642-78163-6_22
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