Abstract
Normal skin color changes occur as consequences of either vascular or pigmentary modifications. Up to now, skin color modifications were usually assessed using various arbitrary visual scales. Numerous attempts to objectively quantity such modifications were performed. Thus, erythema caused by dermal vasodilation can be evaluated by either laser Doppler velocimetry [1] or spectrophotometry [2] However, vasoconstriction-induced blanching and disturbances of the melanin system (hypermelanosis, e. g., tanning, and hypo-, or amelanosis, e. g., nevus depigmentosa, vitiligo,) have remained difficult to quantity objectively.
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References
Willis CM, Stephen CJ, Stephen M, Wilkinson JD (1988) Assessment of erythema in irritant contact dermatitis. Comparison between visual scoring and laser Doppler flowmetry. Contact Dermatitis 18: 138–142
Mendelow AY, Forsyth A, Feather JW, Baillie AJ, Florence AT (1986) Skin reflectance measurements of patch test responses. Contact Dermatitis 15: 73–78
McKenzie AW, Stoughton RB (1962) Method for comparing percutaneous absorption of steroids. Arch Dermatol 86: 608–610
Cornell RC, Stoughton RB (1985) Correlation of the vasoconstriction assay and clinical activity in psoriasis. Arch Dermatol 121: 63–67
1983) Dermocorticoïdes (fiche de transparence). Direction de la Pharmacie et du Médica-ment, p, 13
Aiache JM, Lafaye C, Bouzat J, Rabier R (1980) Evaluation de la disponibilité topique des corticoïdes par thermographic. J Pharm Belg 35: 187–195
Thune P, The effect of corticosteroids on skin pulse. In Wilson IC, Marks R (eds) Mechanisms of topical corticosteroid activity. Churchill Livingstone, Edinburgh, pp 25–31
Altmeyer P, Zaun H (1976) Ergebnisse reflexphotometrischer Bestimmungen der Vasocon-striction nach topischer Applikation: IV. Zeitlicher Ablauf der Vasoconstriction und reaktiven Vasodilatation. Arch Dermatol Res 250: 419–420
Feather JW, Ryatt KS, Dawson JB et al. (1982) Reflectance spectrophotometric quantification of skin colour changes induced by topical corticosteroid preparations. Br J Dermatol 106: 436–444
Leveque JL, Poelman MC, Legall F, De Rigal J (1985) New experimental approach to measure the skin-reflected light. Application to cutaneous erythema and blanching. Dermatologica 170: 12–16
Kiraly K,Soos G (1976) Objective measurement of topiclaly applied corticosteroids. Der-matologica 152 [Suppl 1]: 133–137
Seitz JC, Whitmore CG (1988) Measurement of erythema and tanning responses in human skin using a tri-stimulus colorimeter. Dermatologica 177: 70–75
Babulak SW, Rhein LD, Scala DD et al. (1986) Quantification of erythema in soap chamber test using the Minolta Chroma (Reflectance) Meter: comparison of instrumental results with visual assessments. J Soc Cosmet Chem 37: 475–476
Westerhof W, Van Hasselt B, Kammeijer A (1986) Quantification of UV-induced erythema with a portable computer controlled chromameter. Photodermatology: 3: 310–314
Queille-Roussel C, Poncet M, Schaeffer H (1991) Quantification of skin colour changes induced by topical corticosteroid preparations using the Minolta Chroma Meter. B J Dermatol 124: 264–270
Waring MJ, Monger L, Hollingsbee DA, Martin GP, Marriott C (1990) Evaluation of the Minolta Chromameter CR200 for the assessment of steroid induced blanching. Pharm Res 7/9 [Suppl]: S50
Pershing LK, Lambert LD, Krueger GG, Shah VP (1991) Reproducibility and correlation of the Minolta R chromameter, tape stripping and visual skin blanching in the assessment of bio-availability of topical 0.05% betamethasone dipropionate formulations. In: Scott RC, Guy RH, Hadgraft J, Bodde HE (eds) Prediction of percutaneous penetration: methods, measurements, modelling. IBC Technical services
Dupuis D, Rougier A, Roguet R, Lotte C, Kalopissis G (1984) In vivo relationship between horny layer reservoir effect and percutaneous absorption in human and rat. J Invest Dermatol 82: 353–356
Chan SY, Li Wan Po A Quantitative skin blanching assay of corticosteroid creams using tri- stimulus colour analysis. J Pharm Pharmacol 44: 371–378
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© 1993 Springer-Verlag Berlin Heidelberg
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Queille-Roussel, C., Duteil, L., Czernielewski, J., Schaefer, H. (1993). Colorimetric Evaluation of the Human Skin Blanching Assay. In: Frosch, P.J., Kligman, A.M. (eds) Noninvasive Methods for the Quantification of Skin Functions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78157-5_7
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DOI: https://doi.org/10.1007/978-3-642-78157-5_7
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