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Use of Noninvasive Methods in Evaluating Different Treatments of Psoriasis and the Effects of UV Exposure on Normal Skin

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Noninvasive Methods for the Quantification of Skin Functions

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Abstract

In this article I will review and comment on two studies which exemplify the use of different noninvasive methods in clinical dermatology research. In one of the studies we followed the healing of psoriasis and evaluated two slightly different treatments. In the other we followed the effect of a single exposure of ultraviolet light on normal skin. The methods used were evaporimetry, laser-Doppler flowmetry, and optothermal infrared spectrometry (OTIS).

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References

  1. Bell AG (1880) On the production and reproduction of sound by light. Am J Sci 20: 305–324

    Google Scholar 

  2. Bowers RE, Dalton D, Fursdon D, Knowelden J (1966) The treatment of psoriasis with UVR, dithranol paste and tar baths. Br J Dermatol 78: 273–281

    Article  PubMed  CAS  Google Scholar 

  3. Diffey BL, Farr PM, Oakley AM (1987) Quantitative studies on UVA-induced erythema in human skin. Br J Dermatol 117: 57–66

    Article  PubMed  CAS  Google Scholar 

  4. Farr PM, Diffey BL (1986) The vascular response of human skin to ultraviolet radiation. Photochem Photobiol 44: 501–507

    Article  PubMed  CAS  Google Scholar 

  5. Frödin T (1988) Evaluation of the state of the skin by assessing cutaneous barrier function, blood flow, and water content. Studies in vivo using evaporimetry, laser-Doppler flowmetry, and optothermal infra-red spectrometry. Medical dissertation no 265, Linköping University

    Google Scholar 

  6. Frödin T, Andersson C (1987) Multiple parameter assessment of skin irritancy. Contact Dermatitis 17: 92–99

    Article  PubMed  Google Scholar 

  7. Frödin T, Helander P, Molin L, Skogh M (1988) Optothermal infrared spectrometry ( OTIS) - a specific method for assessing the hydration of stratum corneum in vivo. Bioeng Skin 4: 115–130

    Google Scholar 

  8. Frödin T, Helander P, Molin L, Skogh M (1988) Hydration of human stratum corneum studied in vivo by optothermal infrared spectrometry, electrical capacitance measurement, and evaporimetry. Acta Derm Venereol (Stockh) 68: 461–467

    Google Scholar 

  9. Frödin T, Molin L, Skogh M (1988) Effects of single doses of UVA, UVB and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, opto-thermal infrared spectrometry, and evaporimetry. Photodermatology 5: 187–195

    Google Scholar 

  10. Frödin T, Skogh M (1984) Measurement of transepidermal water loss using an Evaporimeter to follow the restitution of the barrier layer of human epidermis after stripping the stratum corneum. Acta Derm Venereol (Stockh) 64: 537–540

    Google Scholar 

  11. FrödinT, Skogh M, Molin L (1988) The importance of the coal tar bath in the Ingram treatment of psoriasis. Evaluation by evaporimetry and laser Doppler flowmetry. Br J Dermatol 118: 429–434

    Google Scholar 

  12. Grice KA (1980) Transepidermal water loss. In: Jarret A (ed.) The physiology and patho-physiology of the skin, vol 6. Academic, London, pp 2115–2155

    Google Scholar 

  13. Helander P (1983) Optical spectroscopy using an open photoacoustic cell. Dissertation in science and technology no 90, Linköping University

    Google Scholar 

  14. Ingram IT (1953) The approach to psoriasis BMJ 2: 591–594

    CAS  Google Scholar 

  15. Johnson BE (1984) Reactions of normal skin to solar radiation. In: Jarret A (ed.) The physio-logy and pathophysiology of the skin, vol 8. Academic London, pp 2413–2492

    Google Scholar 

  16. Khan A, Schall LM, Tur E, Maibach HI, Guy RH (1987) Blood flow in psoriatic skin lesions: the effect of treatment. Br J Dermatol 117: 193–201

    Article  PubMed  CAS  Google Scholar 

  17. Klemp P, Staberg B (1983) Cutaneous blood flow in psoriasis. J Invest Dermatol 81: 503– 506

    Google Scholar 

  18. Klemp P, Staberg B (1985) The effects of antipsoriatic treatment on cutaneous blood flow in psoriasis measured by 133Xe washout method and laser Doppler velocimetry. J Invest Dermatol 85: 259–263

    Article  PubMed  CAS  Google Scholar 

  19. Marks J, Rogers S, Chadkirk B, Shuster S (1981) Clearance of chronic plaque psoriasis by anthralin subjective and objective assessment and comparison with photochemotherapy. Br J Dermatol 105 [Suppl 20]: 96–99

    Article  PubMed  Google Scholar 

  20. Nilsson GE (1977) Measurement of water exchange through skin. Med Biol Engl Comput 15: 209–218

    Article  CAS  Google Scholar 

  21. Pearse AD, Gaskell SA, Marks R (1987) Epidermal changes in human skin following irradiation with either UVB or UVA. J Invest Dermatol 88: 83–87

    Article  PubMed  CAS  Google Scholar 

  22. Rajka G, Thune P (1976) The relationship between the course of psoriasis and transepidermal water loss, photoelectric plethysmography and reflex photometry. Br J Dermatol 94: 253–261

    Article  PubMed  CAS  Google Scholar 

  23. Rosario R, Mark GJ, Parrish JA, Mihm MC (1979) Histological changes produced in skin by equally erythemogenic doses of UV—A, UV—B, UV—C and UV—A with psoralens. Br J Dermatol 101: 299–308

    Google Scholar 

  24. Rosencwaig A (1973) Photoacoustic spectroscopy of biological materials. Science 181: 657–658

    Article  PubMed  CAS  Google Scholar 

  25. RyanTJ (1983) Cutaneous circulation. In: Goldsmith LA (ed) Biochemistry and physiology of the skin, vol II. Oxford University Press, Oxford, pp 817–877

    Google Scholar 

  26. Salerud EG, Nilsson GE (1986) Integrating probe for tissue laser Doppler flowmeters. Med Biol Eng Comput 24: 415–419

    Article  PubMed  CAS  Google Scholar 

  27. Serup J, Blichmann C (1987) Epidermal hydration of psoriasis plaques and the relation to scaling; measurement of electrical conductance and transepidermal water loss. Acta Derm Venereol (Stockh) 67: 357–359

    CAS  Google Scholar 

  28. Staberg B, Klemp P (1984) Skin blood flow in psoriasis during Goeckerman or beech tar therapy. Acta Derm Venereol (Stockh) 64: 331–334

    CAS  Google Scholar 

  29. Tagami H, Kanamaru Y, Inoue K, Suehisa S, Inoue F, Iwatsuki K, Yoshikuni K, Yamada M (1982) Water sorption-desorption test of the skin in vivo for functional assessment of the stratum corneum. J Invest Dermatol 78: 425–428

    Article  PubMed  CAS  Google Scholar 

  30. Tagami H, Yoshikuni K (1985) Interrelationship between water-barrier and reservoir functions of pathologic stratum corneum. Arch Dermatol 121: 642–645

    Article  PubMed  CAS  Google Scholar 

  31. Takenouchi M, Suzuki H, Tagami H (1986) Hydration characteristics of pathologic stratum corneum — evaluation of bound water. J Invest Dermatol 87: 574–576

    Article  PubMed  CAS  Google Scholar 

  32. Tenland T (1982) On laser Doppler flowmetry; methods and microvascular applications. Linköping studies in science and technology. Medical dissertation no 136, Linkoping University

    Google Scholar 

  33. Werner Y (1986) The water content of the stratum corneum in patients with atopic dematitis; measurement with the corneometer CM 420. Acta Derm Venereol (Stockh) 66: 281–284

    CAS  Google Scholar 

  34. Young AR, Guy RH, Maibach HI (1985) Laser Doppler velocimetry to quantify UV-B induced increase in human skin blood flow. Photochem Photobiol 42: 385–390

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, University Hospital, Linköping, Sweden

    T. Frodin

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  1. T. Frodin
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Editors and Affiliations

  1. Hautklinik der Städtischen Kliniken Dortmund Lehrstuhl Dermatologie, Universität Witten/Herdecke, Beurhausstr. 40, 4600, Dortmund 1, Germany

    Peter J. Frosch

  2. Department of Dermatology, University of Pennsylvania School of Medicine, 19104-6142, Philadelphia, PA, USA

    Albert M. Kligman M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Frodin, T. (1993). Use of Noninvasive Methods in Evaluating Different Treatments of Psoriasis and the Effects of UV Exposure on Normal Skin. In: Frosch, P.J., Kligman, A.M. (eds) Noninvasive Methods for the Quantification of Skin Functions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78157-5_16

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  • DOI: https://doi.org/10.1007/978-3-642-78157-5_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78159-9

  • Online ISBN: 978-3-642-78157-5

  • eBook Packages: Springer Book Archive

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