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Changes in the Biophysical Environment of Water Following Focal Brain Ischemia in the Rat

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Cerebral Ischemia and Basic Mechanisms

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Abstract

The biophysical environment of water in living systems is of great interest to the study of cell function. Magnetic resonance imaging (MRI) offers the ability non–invasively to assess specific parameters which are sensitive to changes in the biophysical environment of water in tissue. The degree by which water is “influenced” by cellular constituents is defined as that level of influence which is sufficient to result in a measurable difference in MRI parameters. The MRI parameters of interest include the measurement of 1H spin–spin (T2) and spin–lattice (T1) relaxation times, water density (p), the apparent diffusion coefficient of water (ADCW), and exchange rates (Kw) between “bound” and “bulk” water.

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Author information

Authors and Affiliations

  1. NIH Center for Stroke Research, Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, Michigan, USA

    J. A. Helpern, R. J. Ordidge & R. A. Knight

  2. Department of Physics, Oakland University, Rochester, Michigan, USA

    J. A. Helpern & R. J. Ordidge

Authors
  1. J. A. Helpern
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  2. R. J. Ordidge
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  3. R. A. Knight
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, 53127, Bonn, Germany

    Alexander Hartmann

  2. Department of Neurology, Texas Medical Center, The University of Texas, 6431 Fannin, Suite 7.004 MSB, 77030, Houston, TX, USA

    Frank Yatsu

  3. Institut für Physiologie, Universität Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany

    Wolfgang Kuschinsky

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© 1994 Springer-Verlag Berlin Heidelberg

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Helpern, J.A., Ordidge, R.J., Knight, R.A. (1994). Changes in the Biophysical Environment of Water Following Focal Brain Ischemia in the Rat. In: Hartmann, A., Yatsu, F., Kuschinsky, W. (eds) Cerebral Ischemia and Basic Mechanisms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78151-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-78151-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78153-7

  • Online ISBN: 978-3-642-78151-3

  • eBook Packages: Springer Book Archive

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