Models of Neural Circuit Reorganization After Injury

  • F. J. Seil


While regeneration in the peripheral nervous system is a well-recognized phenomenon, it had long been believed that central nervous system (CNS) regeneration either did not occur, or was extremely limited. It remains true that regenerative sprouting, defined as the regrowth of a damaged axon, is commonly initiated, but is usually not successful in the adult mammalian CNS. Several factors contribute to this regenerative failure, including (a) a generally regressive reaction and reduced survival of adult CNS neurons after axonal injury [2]; (b) a nonsupportive environment for axonal growth [43]; and (c) the presence in the CNS of oligodendrocyte- and myelinassociated factors that are inhibitory to axonal growth [29]. Other contributory elements may include a down-regulation in the mature state of the production of molecules that promote neuron survival or neurite extension during development [1].


Purkinje Cell Granule Cell Kainic Acid Cytosine Arabinoside Parallel Fiber 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • F. J. Seil
    • 1
  1. 1.Office of Regeneration Research Programs (151N)VA Medical CenterPortlandUSA

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