Abstract
It has been a widely accepted hypothesis that the vulnerability of the brain cells to brief periods of ischemia is caused by the excitotoxicity of glutamate. As a matter of fact, almost all of these ischemia-susceptive neurons are densely innervated by glutamate fibers. In the case of pyramidal cells in the hippocampal CA1 sector, the glutamate fibers innervate the dendritic and the somal cell layers through multisynaptic, feed-foreward networks from the ipsilateral and the contralateral entorhinal cortex.
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References
Kato H, Liu Y, Araki T and Kogure K (1991) Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects. Brain Res 553: 238–242
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© 1994 Springer-Verlag Berlin Heidelberg
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Sugimoto, A., Takeda, A., Onodera, H., Nakanishi, S., Kogure, K. (1994). Unsettled Role of Glutamate/Glutamate Receptors in Ischemic Excitotoxic Neuronal Damage. In: Hartmann, A., Yatsu, F., Kuschinsky, W. (eds) Cerebral Ischemia and Basic Mechanisms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78151-3_21
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DOI: https://doi.org/10.1007/978-3-642-78151-3_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-78153-7
Online ISBN: 978-3-642-78151-3
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