Uncoupling of Flow and Metabolism in Early Ischemic Stroke
The therapeutic window in ischemic stroke, as may be deducted from experimental results of functional recovery (reviews in Heiss 1992), could be effective for different therapeutic approaches: one short period during which improvement of perfusion is successful in reversing functional deficits and preventing morphological damage, and a probably longer period during which the progressive infarction could be ameliorated by intervention with ongoing deleterious biochemical alterations. Clinical experience indicates that similar conditions do exist in ischemic stroke; their assessment in a clinical setting, however, is extremely difficult since most routine examinations do not yield evidence for viability of tissue, and regional studies of physiologic variables, for example, by positron emission tomography (PET) are prevented in most instances by their logistic complexity.
KeywordsPlacebo Ischemia Adenosine Neurol Peri
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