Abstract
Acidosis and in particular lactacidosis from anaerobic metabolism are considered of primary significance among the consequences of cerebral ischemia, seizures,, and head injury (Siesjo 1981). A marked decrease in brain tissue pH has been demonstrated in cerebral ischemia - even more so in hyperglycemic subjects - where lactic acid may accumulate to 20–30 mM and higher concentrations (Rehncrona et al. 1980; Katsura et al. 1991). Tissue pH may drop to pH 5.5 (Chopp et al. 1988). In consequence, acidosis has since long been suspected as a mediator of brain damage (Siesjö 1981).
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© 1994 Springer-Verlag Berlin Heidelberg
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Klawe, C., Volk, C., Kempski, O. (1994). Effects of Extracellular Acidosis on Glial Cell Intracellular pH: Evidence for a Glial Spatial H+-Buffering Mechanism?. In: Hartmann, A., Yatsu, F., Kuschinsky, W. (eds) Cerebral Ischemia and Basic Mechanisms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78151-3_11
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DOI: https://doi.org/10.1007/978-3-642-78151-3_11
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