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Mangelernährung und Immunsystem

  • H. Schroten
Conference paper

Zusammenfassung

Während schon im 5. Jahrhundert vor Christus in indischen Schriften die enge Beziehung zwischen Ernährung und allgemeiner Gesundheit des Menschen erwähnt wird, beschrieb J.F. Menkel (zitiert bei C.M. Jackson [11]) 1810 erstmals eine Thymusatrophie bei mangelernährten Patienten. Damit war der erste wissenschaftliche Hinweis für einen Zusammenhang zwischen Mangelernährung und Immundefekt erbracht [1]. J. Simon [23] nannte schon 1845 den Thymus ein „Barometer der Mangelernährung“. Heute wissen wir, daß der Thymus ein zentrales Organ der zellvermittelten Immunität darstellt.

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Literatur

  1. 1.
    Beisel WR (1991) The history of nutritional immunology. J Nutr Immunol 1: 1–12Google Scholar
  2. 2.
    Chandra RK (1975 a) Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children. Br Med J 2:583–585Google Scholar
  3. 3.
    Chandra RK (1975b) Antibody formation in first and second generation offspring of nutritionally deprived rats. Science 190: 289–290PubMedCrossRefGoogle Scholar
  4. 4.
    Chandra RK (1990) Micronutrients and immune functions. Ann NY Acad Sci 9–16Google Scholar
  5. 5.
    Chandra RK (1991a) Immunocompetence is a sensitive and functional barometer of nutritional status. Acta Paediatr Scand [Suppl] 374: 129–132CrossRefGoogle Scholar
  6. 6.
    Chandra RK (1991 b) 1990 McCollum Award Lecture. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 53: 1087–1101Google Scholar
  7. 7.
    Chuang JC, Yu CL, Wang SR (1990) Modulation of human lymphocyte proliferation by amino acids. Clin Exp Immunol 81: 173–176PubMedCrossRefGoogle Scholar
  8. 8.
    Daly JM, Reynolds J, Sigal RK, Shou J, Liberman MD (1990) Effect of dietary protein and amino acids on immune function. Crit Care Med 18: S86–S93PubMedCrossRefGoogle Scholar
  9. 9.
    Erickson KL, Adams DA, McNeill C (1983) Dietary lipid modulation of immune responsiveness. Lipids 18: 468–424PubMedCrossRefGoogle Scholar
  10. 10.
    Erickson KL, Adams DA, Scibienski RJ (1986) Dietary fatty acid modulation of murine B-cell responsiveness. J Nutr 116: 1830–1836PubMedGoogle Scholar
  11. 11.
    Jackson CM (1925) The effects of inanition and malnutrition upon growth and structure. Balkiston’s, PhiladelphiaGoogle Scholar
  12. 12.
    Koletzko B, Bretschneider A, Bremer HJ (1985) Fatty acid composition of plasma lipids in acrodermatitis enteropathica before and after zinc supplementation. Eur J Pediatr 143: 310–314PubMedCrossRefGoogle Scholar
  13. 13.
    Koletzko B (1986) Essentielle Fettsäuren: Bedeutung für Medizin und Ernährung. Akt Endokr Stoffw 7: 18–27Google Scholar
  14. 14.
    Koletzko B, Schroten H (1993) Ernährung und Immunfunktionen. In: Wahn U, Seger R, Wahn Y (Hrsg) Pädiatrische Allergologie und Immunologie, 2. Aufl. Fischer, Stuttgart (im Druck)Google Scholar
  15. 15.
    Mack DA, Koletzko B, Cunnane S, Cutz E, Griffiths AM (1989) Acrodermatitis enteropathica with normal serum zinc levels: diagnostic value of small bowel biopsy and essential fatty acid determination. Gut 30: 1426–1429PubMedCrossRefGoogle Scholar
  16. 16.
    Parry-Billings M, Evans J, Calder P, Newsholme EA (1990) Does glutamine contribute to immunosuppression after major burns? Lancet II 336: 523–525Google Scholar
  17. 17.
    Reinhold U (1988) Malnutrition and Immunsystem. Vita Min Spur 3: 7–13Google Scholar
  18. 18.
    Reynolds JV, Daly JM, Zhand S, Evantash E, Shou J, Sigal R, Ziegler MM (1988) Immunomodulatory mechanismus of arginine. Surgery 104: 142–151PubMedGoogle Scholar
  19. 19.
    Reynolds JV, Shou J, Sigal R, Ziegler M, Daly JM (1990) The influence of protein malnutrition on T cell, natural killer cell, and lymphokineactivated killer cell function, and on biological responsiveness to high-dose interleukin-2. Cell Immunol 128: 569–577PubMedCrossRefGoogle Scholar
  20. 20.
    Sakamoto M, Nishioka K (1992) Complement system in nutritional deficiency. In: Simopoulos AP (ed) Nutritional triggers for health and in disease. World Rev Nutr Diet 67: 114–139Google Scholar
  21. 21.
    Schlesinger L, Uauy R (1991) Nutrition and neonatal immune function. Semin Perinatol 15: 469–477PubMedGoogle Scholar
  22. 22.
    Schroten H, Koletzko B, Hanisch FG (1991) Immunologische Aspekte menschlicher Milch. Ernährungsumschau 38: 484–489Google Scholar
  23. 23.
    Simon J (1845) A physiological essay on the thymus gland. Renshaw, LondonGoogle Scholar
  24. 24.
    Uauy R (1989) Dietary nucleotides and requirements in early life. In: Lebenthal E (ed) Textbook of gastroenterology and nutrition in infancy, 2nd edn. Raven, New York, pp 265–280Google Scholar

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© Springer-Verlag Berlin Heidelberg 1993

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  • H. Schroten

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