Zusammenfassung
Als nach dem Treffen der „American Legion“, des mächtigen Veteranenverbandes, 1976, im Jahr der 200. Wiederkehr der Unabhängigkeitserklärung in Philadelphia, viele der Teilnehmer schwer erkrankten und nicht wenige starben, gab es ungeheuere Aufregung und weltweit große Beachtung. Zeitungen und Fernsehen berichteten tagelang an erster Stelle. Etwas vom Besonderen, das die Erkrankung von Anbeginn umgab, begleitet sie bis heute.
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Literatur
Allam AA, Kamholz SL (1989) Legionella pneumonia and AIDS. Chest 95: 707–708
Allen MB, Ray SG, Leitch AG, McHardy GJ (1988) Legionella pneumophila complicating Wegener’s granulomatosis. Chest 94: 1101–1103
Allen TP, Fried JS, Wiegmann TB, Hodges GR, Dixon AY, Lee SH, McDougall ML (1985) Legionnaires’ disease associated with rash and renal failure. Arch Intern Med 145: 729–730
Ampel NM, Rubin FL, Norden CW (1985) Cutaneous abscess caused by Legionella micdadei in an immunosuppressed patient. Ann Intern Med 102: 630–632
Anand CM, Skinner AR, Malic A, Kurtz JB (1983) Interaction of Legionella pneumophila and a free living amoebae ( Acanthamoeba palestinensis ). J Hyg (Camb) 91: 167–178
Andersen RD, Bergan T, Halvorsen K, Kallings I, Orstavik I (1981) Legionnaires’ disease combined with erythema multiforme in 3-year old boy. Acta Paediatr Scand 70: 427–430
Andersen RD, Lauer BA, Fraser DW, McIntosh K (1981) Infections with Legionella pneumophila in children. J Infect Dis 143: 386–390
Anderson BB, Sogaard J (1987) Legionnaires’ disease and brain abscess. Neurology 37: 333–334
Anhalt JP (1985) Assays for antimicrobial agents in body fluids. In: Manual of Clinical Microbiology, 4th edn. American Society for Microbiology, Washington DC, pp 1009–1014
Arneborn P, Kallings J (1985) Acute pancreatitis possibly caused by Legionella micdadei. Scand J Infect Dis 17: 229–231
Arnow PM, Boyko EI, Friedman EL (1983) A rectal abscess caused by Legionella pneumophila and mixed anaerobic bacteria. Ann Intern Med 98: 184–185
Arnow PM, Chou T, Weill D, Shapiro EN, Kretzschmar C (1982) Nosocomial Legionnaires’ disease caused by aerosolized tap water from respiratory devices. J Infect Dis 146: 460–467
Aubert G, Bornstein N, Rayet J, Pozzetto B, Lenormand PH (1990) Nosocomial infection with Legionella pneumophila serogroup 1 and 8 in a neonate. Scand J Infect Dis 22: 367–370
Ausina V, Coll P, Sambeat M et al. (1988) Prospective study on the etiology of community-acquired pneumonia in children and adults in Spain. Eur J Clin Microbiol Infect Dis 7: 343–347
Bacheson MA, Friedman HM, Benson CE (1981) Antimicrobial suspectibility of intracellular Legionella pneumophila. Antimicrob Agents Chemother 20: 691–692
Baine WB (1985) Cytolytic and phospholipase C activity in Legionella species. J Gen Microbiol 131: 1383–1391
Baine WB, Rasheed JK (1979) Aromatic substrate specificity of browning by cultures of the Legionnaires’ disease bacterium. Ann Intern Med 90: 619–620
Banford JM, Hakin RN (1982) Chorea after Legionnaires’ disease. Br Med J 284: 1232–1233
Bangsborg JM, Collins MT, Hoiby N, Hinderson P (1989) Cloning and expression of the Legionella micdadei „common antigen„ in Escherichia coli. Acta Pathol Microbiol Immunol Scand [B] 97: 14–22
Barbaree JM, Sanchez A, Sanden G (1983) Tolerance of Legionella species to sodium chloride. Curr Microbiol 9: 1–5
Barendregt JN, Kullberg BJ, Wenning JJ, Van Es LA, Van der Woude FJ (1988) Legionella infection with acute renal failure on thrombocytopenia mimicking allograft rejection. Transpl Int 1: 222–225
Barka N, Tomasi JP, Stadtsbaeder S (1986) ELISA using whole Legionella pneumophila cell as antigen. Comparison between monovalent and polyvalent antigens for the serodiagnosis of human legionellosis. J Immunol Methods 93: 77–81
Barker JE, Farrell ID (1990) The effect of single and combined antibiotics on the growth of Legionella pneumophila using time-kill studies. J Antimicrob Chemother 26: 45–53
Bartlett CLR (1979) Sporadic cases of Legionnaires’ disease in Great Britain. Ann Intern Med 90: 592–595
Bartlett CLR, Swann RA, Casal J, Canada Royo L, Taylor AG (1984) Recurrent Legionnaires’ disease from a hotel water system. In: Thornsberry C, Balows A, Feeley JC, Jakubowski W (eds) Legionella. Proc 2nd Int Symposium, American Society for Microbiology, Washington DC, pp 237–239
Baskerville A, Dowsett AB, Fitzgeorge RB, Hambleton P, Broster M (1983) Ultra-structure of pulmonary alveoli and macrophages in experimental Legionnaires’ disease. J Pathol 140: 77–90
Baskerville A, Fitzgeorge RB, Broster M, Hambleton P (1983) Histopathology of experimental Legionnaires’ disease in guinea pigs, rhesus monkeys and marmosets. J Pathol 139: 349–362
Baskerville A, Fitzgeorge RB, Conlan JW, Ashworth LA, Gibson DH, Morgan CP (1983) Studies on protective immunity to aerosol challenge with Legionella pneumophila. Zentralbl Bakteriol Mikrobiol Hyg [A] 255: 150–155
Bassett F, Ferrans VJ, Soler P, Takemura T, Fukuda Y, Crystal RG (1986) Intraluminal fibrosis in intestinal lung disorders. Am J Pathol 122: 443–461
Bauer R, Hahn T, Botzenhart K (1990) Der Nachweis von Legionellen im Wasserleitungsnetz mittels Gen-Sonden-Technik and Kulturverfahren. Zentralbl Hyg Umweltmed 190: 78–83
Bellinger-Kawahara CG, Horwitz MA (1987) The major outer protein is a prominent acceptor molecule for complement component C3 on Legionella pneumophila. Clin Res 35: 468A
Benson RF, Malcolm GB, Pine L, Harrell WK (1983) Factors influencing the reactivity of Legionella antigens in immunofluorescence tests. J Clin Microbiol 17: 909–917
Benson RF, Thacker WL, Wilkinson HW, Fallon RJ, Brenner DJ (1988) Legionella pneumophila serogroup 14 isolated from patients with fatal pneumonia. J Clin Microbiol 26: 382
Bercovier H, Steigerwalt AG, Derhi-Cochin M, Moss CW, Wilkinson HW, Benson RF, Brenner DJ (1986) Isolation of legionellae from oxidation ponds and fishponds in Israel and description of Legionella israelensis sp. nov.. Int J Syst Bacteriol 36: 368–371
Berdal BP, Farshy CE, Feeley JC (1979) Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay. J Clin Microbiol 9: 575–578
Bertrand A, Janbon F, Despaux E, Jonquet O, Reynes J (1987) L’ofloxacine (RU 43280). Etude clinique. Pathol Biol (Paris) 35: 629–633
Best M, Yu VL, Stout J, Goetz A, Muder RR, Taylor F (1983) Legionellaceae in the hospital water-supply. Epidemological link with disease and evaluation of a method for control of nosocomial Legionnaires’ disease and Pitsburgh pneumonia. Lancet 2: 307–310
Beyer P, Kahn D, Horbach J, Schmid H, Graf W, Weber B (1984) Unusual progression of a Legionella pneumophila infection in a young child. Eur J Pediatr 141: 173–175
Bhardwaj N, Horwitz MA (1988) Interferon-gamma and antibiotics fail to act synergistically to kill Legionella pneumophila in human monocytes. J Interferon Res 8: 283–293
Bhardwaj N, Nash T, Horwitz MA (1986) Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 137: 2662–2669
Bishop DHL, Pandya KP, King HK (1962) Ubiquinone and vitamin K in bacteria. Biochem J 83: 606–614
Black WJ, Quinn FD, Tompkins LS (1990) Legionella pneumophila zinc metallo-protease is structurally and functionally homologous to Pseudomonas aeruginosa elastase. J Bacteriol 172: 2608–2613
Blackmon JA, Chandler FW, Cherry WB et al. (1981) Legionellosis. Am J Pathol 103: 429–465
Blackmon JA, Harley RA, Hicklin MD, Chandler FW (1979) Pulmonary sequelae of acute Legionnaires’ disease pneumonia. Ann Intern Med 90: 552–554
Blanchard DK, Djeu JY, Klein TW, Friedman H, Stewart WE 2nd. (1988) Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function. J Leukocyte Biol 43: 429–435
Blanchard DK, Friedman H, Stewart WE II., Klein TW, Djeu JY (1988) Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model. Infect Immun 56: 1187–1193
Blanchard DK, Friedman H, Klein TW, Djeu JY (1989) Induction of interferon-gamma and tumor necrosis factor by Legionella pneumophila: augmentation of human neutrophil bactericidal activity. J Leukocyte Biol 45: 538–545
Blander SJ, Horwitz MA (1989) Vaccination with the major secretory protein of Legionella pneumophila induces cell-mediated and protective immunity in a guinea pig model of Legionnaires’ disease. J Exp Med 169: 691–705
Bollin GE, Plouffe JF, Para MF, Hackman B (1985) Aerosols containing Legionella pneumophila generated by shower heads and hot-water faucets. Appl Environ Microbiol 50: 1128–1131
Bollin GE, Plouffe JF, Para MF, Prior RB (1985) Difference in virulence of environmental isolates of Legionella pneumophila. J Clin Microbiol 21: 674–677
Bornstein N, Fleurette J, Bebear C, Chabanon G (1987) Bacteriological and aerological diagnosis of community-acquired acute pneumonia, specially Legionnaires’ disease. Multicentric prospective study of 274 hospitalized patients. Zentralbi Bakteriol Mikrobiol Hyg [A] 264: 93–101
Bornstein N, Mercatello A, Marmet D, Sugot M, Deveaux Y, Fleurette J (1989) Pleural infection caused by Legionella anisa. J Clin Microbiol 27: 2100–2101
Bottger EC (1989) Rapid determination of bacterial ribosomal RNA sequences by direct sequencing of enzymatically amplified DNA. FEMS Microbiol Lett 53: 171–176
Botzenhart K, Heizmann W, Sedaghat S, Heeg P, Hahn T (1986) Bacterial colonization and occurrence of Legionella pneumophila in warm and cold water, in faucet aerators, and in drains of hospitals. Zentralbl Bakteriol Mikrobiol Hyg [B] 183: 79–85
Boucree MC (1988) Legionnaires’ disease and acute renal failure: a case report and literature review. J Natl Med Assoc 80: 1065–1071
Boyd JF, McWilliams E (1982) Immunoperoxidase staining of Legionella pneumophila. Histopathology 6: 191–196
Brabender W, Hinthorn DR, Asher M, Lindsey NJ, Lin C (1983) Legionella pneumophila wound infection. JAMA 250: 3091–3309
Brady MT (1989) Nosocomial Legionnaires’ disease in a children’s hospital. J Pediatr 115: 46–50
Breiman RF, Horwitz MA (1987) Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. J Exp Med 165: 799–811
Brenner DJ (1986) Classification of Legionellaceae. Current status and remaining questions. Isr J Med Sci 22: 620–632
Brenner DJ, Steigerwalt AG, Gorman GW et al. (1980) Legionella bozemanii sp. nov. and Legionella dumoffii sp. nov.: classification of two additional species of Legionella associated with human pneumonia. Curr Microbiol. 4: 111–116
Bridge JA, Edelstein PH (1983) Oropharyngeal colonization with Legionella pneumophila. J Clin Microbiol 18: 1108–1112
Brenner DJ, Feeley JC, Weaver RE (1984) Legionellaceae. In: Bergey’s Manual of Systematic Bacteriology. Baltimore, London, pp 279–288
Brenner DJ, Steigerwalt AG, Gorman GW et al. (1985) Ten new species of Legionella. Int J Syst Bacteriol 35: 50–59
Brenner DJ, Steigerwalt AG, Epple P et al. (1988) Legionella pneumophila serogroup Lansing 3 isolated from a patient with fatal pneumonia, and descriptions of L. pneumophila subsp. pneumophila subsp. nov., L. pneumophila subsp. fraseri subsp. nov., and L. pneumophila subsp. pascullei subsp. nov.. J Clin Microbiol 26: 1695–1703
Brindle RJ, Stannett PJ, Tobin JO (1987) Legionella pneumophila: monoclonal antibody typing of clinical and environmental isolates. Epidemiol Infect 99: 235–239
Brivet F, Pham-Van T, Petitpretz P, Delfraissy JF (1984) Rhabdomyolysis–acute renal failure and Legionnaires’ disease. Chest 86: 943–944
Brooks RG, Hofflin JM, Jamieson SW, Stinson EB, Remington JS (1985) Infectious complications in heart-lung transplant recipients. Am J Med 79: 412–422
Broome CV, Fraser DW (1979) Epidemiological aspects of legionellosis. Epidemiol Rev 1: 1–16
Broome CV, Cherry WB, Winn WC jr., McPherson BR (1979) Rapid diagnosis of Legionnaires’ disease by direct immunofluorescent staining. Ann Intern Med 90: 1–4
Broome CV, Goings SAJ, Thacker SB, Vogt RL, Beaty HL, Fraser DW (1979) The Vermont epidemic of Legionnaires’ disease. Ann Intern Med 90: 573–577
Brown A, Vickers RM, Elder EM, Lema M, Garrity GM (1982) Plasmid and surface antigen markers of endemic and epidemic Legionella pneumophila strains. J Clin Microbiol 16: 230–235
Brown A, Lema M, Ciesielski CA, Blaser MJ (1985) Combined plasmid and peptide analysis of clinical and environmental Legionella pneumophila strains associated with a small cluster of Legionnaires’ Disease cases. Infection 13: 163–166
Bull DW, Scott JP, Breathnach SM (1987) Henoch-Schoenlein purpura associated with Legionnaires’ disease. Br Med J Clin Res 294: 220
Bundesgesundheitsamt (1987) BGA: Empfehlungen des Bundesgesundheitsamtes zur Verminderung eines Legionella-Infektionsrisikos. Bundesgesundheitsblatt 30: 252–253
Canaud B, Beraud JJ, Mion C, Baldet P, Minran A (1989) Successful treatment of Legionella-associated haemolytic uraemic syndrome with acute renal failure and malignant hypertension by prostacyclin (epoprostenol). Nephrol Dial Transplant 4: 996–999
Carlson NC, Kuskie MR, Dobyns EL, Wheeler MC, Roe MH, Abzug MJ (1990) Legionellosis in children: an expanding spectrum. Pediatr Infect Dis J 9: 133–137
Castellani-Pastoris M, Nigro G, Mazzotti MF, Midulla M (1984) Legionella pneumophila infection associated with arrhythmia or myocarditis in children without pneumonia. In: Thornsberry C, Balows A, Feeley JC, Jakubowski W (eds) Legionella. Proc 2nd Int Symposium, American Society for Microbiology, Washington DC, pp 14–15
Castellani-Pastoris M, Vigano EF, Passi C (1988) A familiy cluster of Legionella pneumophila infections. Scand J Infect Dis 20: 489–493
Catrenich CE, Johnson W (1988) Virulence conversion of Legionella pneumophila: a one-way phenomenon. Infect Immun 56: 3121–3125
Cayla JA, Sala MR, Plasencia A, Beneyto V, Sureda V, Llorens M, Batalla J (1989) A community outbreak of Legionnaires’ disease in Barcelona: epidemiologic and environmental study. Med Clin (Barc) 93: 526–530
Cercenado E, Edelstein PH, Gosting LH, Sturge JC (1987) Legionella micdadei and Legionella dumoffii monoclonal antibodies for laboratory diagnosis of Legionella infections. J Clin Microbiol 25: 2163–2167
Chandler FW, Roth IL, Callaway CS, Bump JL, Thomason BM, Weaver RE (1980) Flagella on Legionnaires’ disease bacteria: ultrastructural observations. Ann Intern Med 93: 711–714
Chastre J, Raghu G, Soler P, Brun P, Bassel F, Gibert C (1987) Pulmonary fibrosis following pneumonia due to acute Legionnaires’ disease. Chest 91: 57–62
Cherry WB, McKinney RM (1978) Detection in clinical specimens by direct immunofluorescence. In: Legionnaires’, the disease, the bacterium and methodology. Jones JL, Hébert GA (eds). Centers for Disease Control, Atlanta, pp 130–145
Cherry WB, Pittman B, Harris PP, Hebert GA, Thomason BM, Thacker WL, Weaver RE (1978) Detection of Legionnaires’ disease bacteria by direct immunofluorescent staining. J Clin Microbiol 8: 329–338
Chester B, Poulos EG, Demaray MJ, Albin E, Prilucik T (1983) Isolation of Legionella pneumophila serogroup 1 from blood with non-supplemented blood culture bottles. J Clin Microbiol 17: 195–197
Chidiac C, Leroy O, Beuscart C, Le Chevalier B, Beaucaire G, Mouton Y and Group Study (1989) Efficacy and safety of oral ofloxacin for treatment of pneumonia. Rev Infect Dis 11 [suppl]: 1223–1224
Chiodini PL, Barker J (1984) Successful treatment of Legionella pneumonia with imipenem. Lancet 1: 401
Christopher PJ, Noonan LM, Chiew R (1987) Epidemic of Legionnaires’ disease in Wollongong. Med J Aust 147: 127–128
Cianciotto NP, Eisenstein BI, Mody CH, Toews GB, Engleberg NC (1989) A Legionella pneumophila gene encoding a species-specific surface protein potentiates the initiation of intracellular infection. Infect Immun 57: 1255–1262
Cohen ML, Broome CV, Paris AL, Martin WT, Allen JR (1979) Fatal nosocomial Legionnaires’ disease: clinical and epidemiologic characteristics. Ann Intern Med 90: 611–613
Colbourne JS, Pratt DJ, Smith MG, Fisher-Hoch SP, Harper D (1984) Water fittings as sources of Legionella pneumophila in a hospital plumbing system. Lancet 1: 210–213
Collins MT, Jones D (1981) Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implications. Microbiol. Rev 45: 316–354
Collins MT, Espersen F, Hoiby N, Cho SN, Friis-Moller A, Reif JS (1983) Cross-reactions between Legionella pneumophila (serogroup 1) and twenty-eight other bacterial species, including other members of the family Legionellaceae. Infect Immun 39: 1441–1456
Conlan JW, Ashworth LA (1986) The relationship between the serogroup antigen and lipopolysaccharide of Legionella pneumophila. J Hyg (London) 96: 39–48
Copeland JG, Mammana RB, Fuller JK, Campbell DW, McAleer MJ, Sailer JA (1984) Heart transplantation: four years’ experience with conventional immunosuppression. JAMA 251: 1563–1566
Cordes LG, Wiesenthal AM, Gorman GW et al. (1981) Isolation of Legionella pneumophila from hospital shower heads. Ann Intern Med 94: 195–197
Corpier CL, Jones PH, Suki WN, Lederer ED, Quinones MA, Schmidt SW, Young JB (1988) Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients. JAMA 260: 239–241
Cossar JH, Dewar RD, Fallon RJ, Grist NR, Reid D (1982) Legionella pneumophila in tourists. Practitioner 226: 1543–1548
Cossar JH, Reid D, Fallon RJ et al. (1990) A cumulative review of studies on travellers, their experience of illness and the implications of these findings. J Infect 21: 27–42
Cutz E, Thorner PS, Rao CP, Toma S, Gold R, Gelfand EW (1982) Disseminated Legionella pneumophila infection in an infant with severe combined immunodeficiency. J Pediatr 100: 760–762
Daisy JA, Benson CE, McKitrick J, Friedman HM (1981) Intracellular replication of Legionella pneumophila. J Infect Dis 143: 460–464
Davis GS, Winn WC Jr, Gump DW, Beaty HN (1983) The kinetics of early inflammatory events during experimental pneumonia due to Legionella pneumophila in guinea pigs. J Infect Dis 148: 823–835
De Truchis P, Dournon E, Gluckman E, Touboul JL, Mayaud C, Akoun G (1988) Maladie des legionnaires avex pancytopenie et isolement de legionelles par hemocultures et cultures de moelle osseuse. Presse Med 17: 34–35
De Vivo F, Pond GD, Rhenman B, Icenogle TB, Vasu MA, Copeland JG (1988) Transtracheal aspiration and fine needle aspiration biopsy for the diagnosis of pulmonary infection in heart transplant patients. J Thorac Cardiovasc Surg 96: 696–699
De-Freitas JL, Borst J, Meenhorst PL (1979) Easy visualisation of Legionella pneumophila by „half-a-gram„ stain procedure. Lancet 1: 270–271
Deforges L, Foumet MP, Soussy CJ, Duval J (1986) In vitro antibacterial activity of the quinolones against twenty strains of Legionella pneumophila. Pathol Biol (Paris) 34: 631–633
Denning D, Thomas P, Harries M, Wall R (1987) Whole blood exchange as treatment for legionellosis. Lancet 1: 227
Dennis PJL, Wright AE, Ruther DA (1984) Legionella pneumophila in aerosols from showerbaths. J Hyg (Camb) 93: 349
Dieterle RR (1927) Method for demonstration of Spirocheata pallida in single microscopic sections. Arch Neurol Psychiatry 18: 73–80
Dietrich PA, Johnson RD, Fairbank JT, Walke JS (1978) The chest radiograph in Legionnaires’ disease. Radiology 127: 577–582
Doebbeling BN, Bale MJ, Koontz FP, Helms CM, Wenzel RP, Pfaller MA (1988) Prospective evaluation of the gen-probe assay for detection of legionellae in respiratory specimens. Eur J Clin Microbiol Infect Dis 7: 748–752
Doebbeling BN, Ishak MA, Wade BH et al. (1989) Nosocomial Legionella micdadei pneumonia: 10 years experience and a case control study. J Hosp Infect 13: 289–298
Domingo C, Roig J, Seres J (1989) Pericardial effusion as a clinical sign of Legionnaires’ disease. Int J Cardiol 23: 407–409
Dondero TJ, Rendtorff RC, Mallison GF, Weeks RM, Levy JS, Wong EW, Schaffner W (1980) An outbreak of Legionnaires’ disease associated with a contaminated air-conditioning cooling tower. New Engl J Med 302: 365–370
Dorman SA, Hardin NJ, Washington CW (1980) Pyelonephritis associated with Legionella pneumophila serogroup 4. Ann Intern Med 93: 835–837
Dournon E, Bure A, Desplaces N, Carette MF, Mayaud CH (1982) Legionnaires’ disease related to gastric lavage with tap water. Lancet 1: 797–798
Dournon E, Bure A, Kemeny J, Pourriat JL, Valeyre D (1982) Legionella pneumophila peritonitis. Lancet 2: 1363
Dournon E, Bibb WF, Rajagopalan P, Desplaces N, McKinney RM (1988) Monoclonal antibody reactive as a virulence marker for Legionella pneumophila serogroup 1 strains. J Infect Dis 157: 496–501
Dournon E, Mayaud C, Wolff M, Schlemmer B, Samuel D, Sollet JP, Levasseur-Rajagopalan P (1990) Comparison of the activity of three antibiotic regimens in severe Legionnaires’ disease. J Antimicrob Chemother 26 [Suppl B]: 129–139
Dowling JN, Kroboth FJ, Karpf M, Yee RB, Pasculle AW (1983) Pneumonia and multiple lung abscesses caused by dual infection with Legionella micdadei and Legionella pneumophila. Am Rev Respir Dis 127: 121–125
Dowling JN, McDevitt DA, Pasculle AW (1985) Isolation and preliminary characterization of erythromycin-resistant variants of Legionella micdadei and Legionella pneumophila. J Antimicrob Agents Chemother 27: 272–274
Dreyfus LA, Iglewksi BH (1986) Purification and characterization of an extracellular protease of Legionella pneumophila. Infect Immun 51: 736–743
Dummer JS, Bahnson HT, Griffith BP, Hardesty RL, Thompson ME, Ho M (1983) Infections in patients on cyclosporine and prednisone following cardiac transplantation. Transplant Proc 15: 2779–2781
Dworzack DL, Ferry JJ, Clark RB (1989) Co-infection with Legionella pneumophila and Pneumocystis carinii in a patient with chronic lymphocytic leukemia. Nebr Med J 74: 73–75
Edelstein PH (1981) Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and enviromental specimens. J Clin Microbiol 14: 298–303
Edelstein PH (1985) Legionella. In: Manual of Clinical Microbiology, 4th edn, American Society for Microbiology. Washington DC, pp 373–381
Edelstein PH (1986) Evaluation of the gen-probe DNA probe for the detection of legionellae in culture. J Clin Microbiol 23: 481–484
Edelstein PH (1987) The laboratory diagnosis of Legionnaires’ disease. Semin Respir Infect 2: 235–241
Edelstein PH (1987) Laboratory diagnosis of infections caused by legionellae. Eur J Clin Microbiol Infect Dis 6: 4–10
Edelstein PH, Edelstein MAC (1991) In vitro activity of azithromycin against clinical i solates of Legionella species. Antimicrob Agents Chemother 35: 180–181
Edelstein PH, Meyer RD (1980) Susceptibility of Legionella pneumophila to twenty antimicrobial agents. Antimicrob Agents Chemother 18: 403–408
Edelstein PH, Meyer RD (1984) Legionnaires’ disease. A review. Chest 85: 114–120
Edelstein PH, Meyer RD, Finegold SM (1979) Isolation of Legionella pneumophila from blood. Lancet 1: 750–751
Edelstein PH, Meyer RD, Finegold SM (1980) Laboratory diagnosis of Legionnaires’ disease. Am Rev Respir Dis 121: 317–327
Edelstein PH, Brenner DJ, Moss CW, Steigerwalt AG, Francis EM, George WL (1982) Legionella wadsworthii species nova: a cause of human pneumonia. Ann Intern Med 97: 809–813
Edelstein PH, Calarco K, Yasui VK (1984) Antimicrobial therapy of experimentally induced Legionnaires’ disease in guinea pigs. Am Rev Respir Dis 130: 849–856
Edelstein PH, Bryan RN, Enns RK, Kohne DE, Kacian DL (1987) Retrospective study of Gen-Probe rapid diagnostic system for detection of legionellae in frozen clinical respiratory tract samples. J Clin Microbiol 25: 1022–1026
Edelstein PH, Gaudet EA, Edelstein MA (1989) In vitro activity of lomefloxacin (NY-198 or SC 47111), ciprofloxacin and erythromycin against 100 clinical Legionella strains. Diagn Microbiol Infect Dis 12: 93S - 95S
Edelstein PH, Edelstein MAC, Weidenfeld J. Don MB (1990) In vitro activity of sparfloxacin (CI-978; AT-4140) for clinical Legionella isolates, pharmacokinetics in guinea pigs, and use to treat guinea pigs with Legionella pneumophila pneumonia. Antimicrob Agents Chemother 34:2122–2127
Edson DC, Stiefel HE, Wentworth BB, Wilson DL (1979) Prevalence of antibodies to Legionnaires’ disease. A seroepidemiologic survey of Michigan residents using the hemagglutination test. Ann Intern Med 90: 691–693
Edwards R, Feltham RKA (1983) Taxonomic implication of the cellular fatty acid content of the Legionellaceae and possibly related species. FEMS Microbiol Lett 17: 251–255
Ehret W (1989) Methoden and Probleme der Legionellendiagnostik. Immun Infekt 17: 4–12
Ehret W, Ruckdeschel G (1983) Species specific membrane proteins of Legionellaceae. Zentralbl Bakteriol Mikrobiol Hyg [A] 255: 33–38
Ehret W, Ruckdeschel G (1985) Membrane proteins of legionellaceae. I. Membrane proteins of different strains and serogroups of Legionella pneumophila. Zentralbl Bakteriol Hyg [A] 259: 433–445
Ehret W, Von Specht JH, Ruckdeschel G (1986) Discrimination between clinical and environmental strains of Legionella pneumophila by a monoclonal antibody. Isr J Med Sci 22: 715–723
Ehret W, Jacob K, Ruckdeschel G (1987) Identification of clinical and environmental isolates of Legionella pneumophila by analysis of outer-membrane proteins, ubiquinones and fatty acids. Zentralbl Bakteriol Mikrobiol Hyg [A] 266: 261–275
Ehret W, Klatte J, Ruckdeschel G, Anding G (1991) Identifikation des Trinkwassernetzes als Quelle eines nosokomialen Ausbruchs der Legionärskrankheit mittels Analyse genomischer Fragmente und anderer Typisierungsverfahren. Arbeitstagung der DGHM, Berlin: 14.-15. März, Abstract Nr.: 43
Eisenstein TK, Tamade R, Meissler J, Flesher A, Oels HC (1984) Vaccination against Legionella pneumophila: serum antibody correlates with protection induced by heat-killed or acetone-killed cells against intraperitoneal but not aerosol infection in guinea pigs. Infect Immun 45: 685–691
Eitrem R, Forsgren A, Nilsson C (1987) Pneumonia and acute pancreatitis most probably caused by a Legionella longbeachae infection. Scand J Infect Dis 19: 381–382
Elder EM, Brown A, Remington JS, Shonnard J, Naot Y (1983) Microenzyme-linked immunosorbent assay for detection of immunoglobulin G and immunoglobulin M antibodies to Legionella pneumophila. J Clin Microbiol 17: 112–121
Elliott JA, Johnson W (1982) Virulence conversion of Legionella pneumophila serogroup 1 by passage in guinea pigs and embryonated eggs. Infect Immun 35: 943–946
Ellner PD, Johnson E, Hosmer M, Rodriguez E (1985) Rarity of Legionella species in routine sputum specimens. Eur J Clin Microbiol Infect Dis 4: 425
England AC, Fraser DW, Plikaytis BD, Tsai TF, Storch G, Broome CV (1981) Sporadic legionellosis in the United States: the first thousand cases. Ann Intern Med 94: 164–170
Engleberg NC, Carter C, Weber DR, Cianciotto NP, Eisenstein BI (1989) DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity. Infect Immun 57: 1263–1270
Engleberg NC, Drutz DJ, Eisenstein BI (1984) Cloning and expression of Legionella pneumphila antigens in Escherichia coli. Infect Immun 44: 222–227
Engleberg NC, Pearlman E, Eisenstein BI (1984) Legionella pneumophila surface antigens cloned and expressed in Escherichia coli are translocated to the host cell surface and interact with specific anti-Legionella antibodies. J Bacteriol 160: 199–203
Engleberg NC, Pearlman E, Dixon D, Eisenstein BI (1986) Antibodies isolated by using cloned surface antigens recognize antigenically related components of Legionella pneumophila and other Legionella species. J Immunol 136: 1415–1417
Evans AF, Oakley RH, Whitehouse GH (1981) Analysis of the chest radiograph in Legionnaires’ disease. Clin Radiol 32: 361–365
Exner M (1991) Verhütung, Erkennung und Bekämpfung von Legionelleninfektionen im Krankenhaus. Das Krankenhaus 10: 460–523
Exner M, Jung KD, Haardt B (1990) Nosokomiale Legionellen-Infektion im Zusammenhang mit einer systemischen Legionellen-Kontamination des Hausinstallationssystems und Erfahrungen zur Sanierung. Forum Städte-Hygiene 41: 289–293
Faine S (1965) Silver staining of spirochaetes in single tissue sections. J Clin Pathol 18: 381–382
Faine S, Edelstein PH, Kirby BD, Finegold SM (1979) Rapid presumptive bacteriological diagnosis of Legionnaires’ disease. J Clin Microbiol 10: 104–105
Fairbank JT, Mamourian AC, Dietrich PA, Girod JC (1983) The chest radiograph in Legionnaires’ disease. Further observations. Radiology 147: 33–34
Fallon RJ, Abraham WH (1982) Polyvalent heat-killed antigen for the diagnosis of infection with Legionella pneumophila. J Clin Pathol 35: 434–438
Fallon RJ, Rowbotham Tt (1990) Microbiological investigations into an outbreak of Pontiac fever due to Legionella micdadei associated with use of a whirlpool. J Clin Pathol 43: 479–483
Fang DG, Yu VL, Vickers RM (1989) Disease due to the Legionellaceae (other than Legionella pneumophila). Medicine (Baltimore) 68: 116–132
Fang DG, Fine M, Orloff Jet al. (1990) New and emerging etiologies for community-acquired pneumonia with implications for therapy. A prospective multicenter study of 359 cases. Medicine (Baltimore) 69: 307–316
Fan BM, Kaiser DL, Harrison BD, Connolly CK (1989) Prediction of microbial aetiology at admission to hospital for pneumonia from the presenting clinical features. Thorax 44: 1031–1035
Fanant JM, Drury AE, Thompson RP (1988) Legionnaires’ disease following immersion in a river. Lancet 2: 460
Farrell ID, Barker J, Chiodini PL, Hutchison JGP, Geddes AM (1985) The activity of imipenem on Legionella pneumophila, with a note on the treatment of two cases. J Antimicrob Chemother 16: 61–65
Farrington M, French GL (1983) Legionella pneumophila seen in Gram stains of respiratory sections and recovered from conventional blood cultures. J Infect 6: 123–127
Farshy CE, Klein GC, Feeley JC (1978) Detection of antibodies to Legionnaires’ disease organism by microagglutination and micro-enzyme-linked immunosorbent assay tests. J Clin Microbiol 7: 327–331
Farshy CE, Cruce DD, Klein GC, Wilkinson HW, Feeley JC (1979) Immunoglobulin specificity of the microagglutination test for the Legionnaires’ disease bacterium. Ann Intern Med 90: 690
Feeley JC, Gorman GW, Weaver RE, Mackel DC, Smith HW (1978) Primary isolation media for Legionnaires’ disease bacterium. J Clin Microbiol 8: 320–325
Fehrenbach FJ, Horbach I, Ruf B, Schürmann D, Pohle HD (1986) Rapid detection of Legionella antigen in tissues and body fluids. Isr J Med Sci 22: 706–710
Fenstersheib MD, Miller M, Diggins C et al. (1990) Outbreak of Pontiac fever due to Legionella anisa. Lancet 1: 35–37
Fergusson RJ, Mine LT (1986) Legionnaires’ disease and IgA nephropathy. Scott Med J 31: 114–116
Fields BS, Shotts EB Jr, Feeley JC, Gorman GW, Martin WT (1984) Proliferation of Legionella pneumophila as an intracellular parasite of the ciliated protozoan Tetrahymena pyriformis. Appl Environ Microbiol 47: 467–471
Fisher-Hoch SP, Bartlett CL, Tobin JO et al. (1981) Investigation and control of an outbreak of Legionnaires’ disease in a district general hospital. Lancet 1: 932–936
Fitzgeorge RB (1985) The effect of antibiotics on the growth of Legionella pneumophila in guinea-pig alveolar phagocytes infected in vivo by an aerosol. J Infect 10: 189–193
Fitzgeorge RB, Featherstone ASR (1989) Roxithromycin of experimental airborne Legionnaires’ disease. J Antimicrob Chemother 23: 462–463
Fitzgeorge RB, Baskerville A, Broster M, Hambleton P, Dennis PJ (1983) Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitonal and intranasal routes of infection. J Hyg (London) 90: 81–89
Fitzgeorge RB, Gibson DH, Jepras R, Baskerville A (1985) Studies on ciprofloxacin therapy of experimental Legionnaires’ disease. J Infect 10: 194–203
Floyd-Reising S, Hindler JA, Young LS (1987) In vitro activity of A-56268 (TE-031), a new macrolide antibiotic, compared with that of erythromycin and other antimicrobial agents. Antimicrob Agents Chemother 31: 640–642
Fogliani J, Domenget JF, Hohn B, Merignargues G, Bornstein N (1982) Maladie des legionnaires avec localisation digestive. Une observation. Presse Med 36: 2699–2702
Foy HM, Broome CV, Hayes PS, Allan I, Cooney MK, Tobe R (1979) Legionnaires’ disease in a prepaid medical-care group in Seattle 1963–75. Lancet 1: 767–770
Fraser DW (1980) Legionnaires’ disease: four summers’ harvest. Am J Med 68: 1–2
Fraser DW, Tsai RF, Orenstein W et al (1977) Legionnaires’ disease: description of an epidemic of pneumonia. N Engl J Med 297: 1189–1197
Fraser DW, Wachsmuth IK, Bopp C, Feeley JC, Tsai TF (1978) Antibiotic treatment of guinea-pigs infected with agent of Legionnaires’ disease Lancet 1: 175–177
Fraser DW, Deubner DC, Hill DL, Gilliam DK (1979) Non-pneumonic, short-incubation-period legionellosis ( Pontiac fever) in men who cleaned a steam turbine condenser. Science 205: 690–691
Freedman AP, Coodley E, Johnston RF, Goodman L, Katz SM (1982) Loculated pleural effusion caused by Legionella pneumophila. Thorax 37: 79–80
Friedland L, Snydman DR, Weingarden AS, Hedges TR 3rd., Brown R, Busky M (1984) Ocular and pericardial involvement in legionnaires’ disease. Am J Med 77: 1105–1107
Friedman HM, Widen R, Lee J, Klein T (1983) Cellular immunity to Legionella pneumophila in guinea pigs assessed by direct and indirect migration inhibition reactions in vitro. Infect Immun 41: 1132–1137
Friedman S, Spitalny K, Barbaree J, Faur Y, McKinney R (1987) Pontiac fever outbreak associated with a cooling tower. Am J Public Health77: 568–572
Fu KP, Neu HC (1979) Inactivation of betalactam antibiotics by Legionella pneumophila. Antimicrob Agents Chemother 16: 561–564
Fuchs GJ 3rd, La Rocco M, Robsinson A, Kohl S (1986) Fatal Legionnaires’ disease in an infant. Pediatr Infect Dis J 5: 377–379
Fukunaga H, Akagi K, Yabuuchi E (1990) Asymptomatic infection of Legionella pneumophila in four cases with pulmonary diseases. Nippon Saikingaku Zasshi 45: 833–840
Fuller J, Levinson MM, Kline JR, Copeland J (1985) Legionnaires’ disease after heart transplantation. Am Thorac Surg 39: 308–311
Fumorola D, Miragliotta C, Logroscino G, Castellani-Pastoris M (1984) Simultaneous infection with Legionella pneumophila and Legionella micdadei in an immunologically intact host. A case report. Boll Ist Sieroter Milan 63: 165–166
Gabay JE, Blake M, Niles WD, Horwitz MA (1985) Purification of Legionella pneumophila major outer membrane protein and demonstration that it is a porin. J Bacteriol 162: 85–91
Garbe PL, Davis BJ, Weisfeld JS, Markowitz L, Miner P, Garrtiy F, Barbaree JM, Reingold AL (1985) Nosocomial Legionnaires’ disease–epidemiologic demonstration of cooling towers as a source. JAMA 254: 521–524
Garrity GM, Brown A, Vickers RM (1980) Tatlockia and Fluoribacter: two new genera of organisms resembling Legionella pneumophila. Int J Syst Bacteriol 30: 609–614
Gasper TM, Farudon PA, Davies R (1978) Thrombocytopenia associated with Legionnaires’ disease. Br Med J 273: 1611–1612
Gatell JM, Miro JM, Sasal M, Ferrer O, Rodriguez M, Garcia-San-Miguel J (1981) Legionella pneumophila antigen in brain. Lancet 2: 202–203
Gea J, Rodriguez-Roisin R, Tones A, Augusti-Vidal A (1988) Lung function changes following Legionnaires’ disease. Eur Respir J 1: 109–114
George JR, Pine L, Reeves MW, Harrell WK (1980) Amino acid requirements of Legionella pneumophila. J Clin Microbiol 11: 286–291
Geuenich HH, Ly TMC, Müller HE (1988) Die Anwendung der Gen-Sonden-Technik zum Nachweis von Legionellen in Wasserproben. Sonderdruck aus Lab med 12: 410–413
Gibson DH, Baskerville A, Ashworth LA, Fitzgeorge RB (1985) Non-specific protection against pulmonary Legionella pneumophila infection in guinea pigs immunized and challenged with mycobacteria. Br J Exp Pathol 66: 333–344
Girod JC, Reichman RC, Winn WC Jr, Klaucke DN, Vogt RL, Dolin R (1982) Pneumonic and non-pneunomic forms of legionellosis. The result of a common-source exposure to Legionella pneumophila. Arch Intern Med 152: 545–547
Glavin FL, Winn WC Jr, Craighead JE (1979) Ultrastructure of lung in Legionnaires’ disease–oberservations of three biopsies done during the Vermont epidemic. Ann Intern Med 90: 555–559
Glick TH, Gregg MB, Berman B, Mattison G, Rhodes WW Jr, Kassanoff J (1978) Pontiac fever: an epidemic of unknown etiology in a health department. I. Clinical and epidemiological aspects. Am J Epidemiol 107: 149–160
Glupczynski Y, Labbe M, Yourassowsky E (1984) Cross-reactivity of environmental bacterial with fluorescent-antibody conjugates for Legionella pneumophila. Eur J Clin Microbiol Infect Dis 3: 215
Goldman JM (1986) Neurogenic bladder in Legionnaires’ disease. Am J Med 80: A65
Golub RJ, Feinsilver SH (1988) Hematuria and Legionella pneumonia. Ann Intern Med 108: 489
Gombert ME, Josephson S, Goldstein EJC, Smith PR, Butt KM (1984) Cavitary legionella pneumonitis: nosocomial infection in renal transplant recipients. Am J Surg 147: 402–405
Gorman GW, Yu VL, Brown A, Hall JA, Corcoran LK, Martin WT, Bibb WF, Morris GK, Magnussen MH, Fraser DW (1980) Isolation of Pittsburgh pneumonia agent from nebulizers used in respiratory therapy. Ann Intern Med 93: 572–573
Gosting LH, Cabrian K, Sturge JC, Goldstein LC (1984) Identification of a species-specific antigen in Legionella pneumophila by a monoclonal antibody. J Clin Microbiol 20: 1031–1035
Granados A, Podzamczer D, Gudiol F, Mauresa F (1989) Pneumonia due to Legionella pneumophila and pneumococcal pneumonia: similarities and differences on presentation. Eur Respir J 2: 130–134
Greer PW, Chandler FW, Hicklin MD (1980) Rapid demonstration of Legionella pneumophila in unembedded tissue. An adaptation of the Gimenez stain. Am J Clin Pathol 73: 788–790
Griffith ME, Lindquist DS, Benson RF, Thacker WL, Brenner DJ, Wilkinson HW (1988) First isolation of Legionella gormanii from human disease. J Clin Microbiol 26: 380–381
Grimont PA, Grimont F, Desplaces N, Tchen P (1985) DNA probe specific for Legionella pneumophila. J Clin Microbiol 21: 431–437
Grommek F (1992) Das klinische Bild der Legionelleninfektion in Deutschland. Inaugural-Diss., München
Gross D, Willens H, Zeldis SM (1981) Myocarditis in Legionnaires’ disease. Chest 79: 232–234
Guiget M, Pierre J, Brun P, Bertholet G, Gottot S, Gibert C, Valleron AJ (1987) Epidemiological survey of a major outbreak of nosocomial legionellosis. Int J Epidemiol 16: 466–471
Guillemain JL, Chapon F, Viader F, Guillo-Lohan A, Lechevalier B (1987) Legionellose pulmonaire avec syndrome cerebelleux et pseudo-bulbaire. Presse Med 16: 538
Gump DW, Frank RO, Winn WC Jr, Foster RS Jr, Broome CV, Cherry WB (1979) Legionnaires’ disease in patients with associated serious disease. Ann Intern Med 90: 538–542
Gutzeit MF, Lauer SJ, Durme WM Jr, Kelly KJ, Chusid MJ (1987) Fatal Legionella pneumonitis in a neutropenic leukemic child. Pediatr Infect Dis J 6: 68–69
Habicht W, Müller HE (1986) Über das Vorkommen von Legionellen in Warmwasserproben aus Krankenhäusern und Hotels. Hyg Med 11: 233–237
Habicht W, Müller HE (1988) Occurence and parameters of frequency of Legionella in warm water systems of hospitals and hotels in Lower Saxony. Zentralbl Bakteriol Mikrobiol Hyg [B] 186: 79–88
Haley CE, Cohen ML, Halter J, Meyer RD (1979) Nosocomial Legionnaires’ Disease: a continuing-common source epidemic at Wadsworth Medical Center. Ann Intern Med 90: 583–586
Hall SL, Wasserman M, Dall L, Schubert T (1983) Acute renal failure secondary to myoglobinuria associated with Legionnaires’ disease. Chest 84: 633–635
Hamedani P, Juzar A, Hafeez S et al. (1991) The safety and efficacy of clarithromycin in patients with legionella pneumonia. Chest 100: 1503–1506
Hara K, Suyama N, Yamaguchi K, Kohno S, Saito A (1987) Activity of macrolides against organisms responsible for respiratory infection with emphasis on Mycoplasma and Legionella. J Antimicrob Chemother 20 [Suppl B1: 75–80
Harris LF (1981) Legionnaires’ disease associated with acute encephalomyelitis. Arch Neurol 38: 462–463
Harris LF (1981) Legionnaires’ disease associated with massive pericardial effusion. Arch Intern Med 141: 1385
Harris P, Ralph P (1985) Human leukemic models of myclomoncytic development: a review of the HL60 and U937 cell lines. J Leukocyte Biol 37: 407–422
Harrison TG, Taylor AG (1982) Diagnosis of Legionella pneumophila infections by means of formolised yolk sac antigens. J Clin Pathol 35: 211–214
Harrison TG, Taylor AG (1988) Identification of legionellae by serological methods. In: Harrison TG, Taylor AG (eds) A Laboratory Manual for Legionella. Wiley & Son, New York, pp 57–69
Harrison TG, Taylor AG (1988) Timing of seroconversion in Legionnaires’ disease. Lancet 1: 795
Havlichek D, Pohlod D, Saravolatz L (1987) Comparison of ciprofloxacin and rifampicin in experimental Legionella pneumophila pneumonia. J Antimicrob Chemother 20: 875–881
Havlichek D, Saravolatz L, Pohlod D (1987) Effect of quinolones and other antimicrobial agents on cell-associated Legionella pneumophila. Antimicrob Agents Chemother 31: 1529–1534
Heath PD, Booth L, Leigh PN, Turner AM (1986) Legionella brain stem encephalopathy and peripheral neuropathy without preceding pneumonia (letter). J Neurol Neurosurg Psychiatry 49: 216–218
Helbig JH, Lück PC, Pilz C, Witzleb W (1990) Common epitope on urinary antigen derived from different Legionella pneumophila serogroup 1 strains recognized by a monoclonal antibody. Int J Med Microbiol 273: 478–480
Helms CM, Viner JP, Sturm RH, Renner ED, Johnson W (1979) Comparative features of pneumococcal, mycoplasmal and Legionnaires’ disease pneumonia. Ann Intern Med 90: 543–547
Helms CM, Johnson W, Donaldson MF, Cony RJ (1981) Pretibial rash in Legionella pneumophila pneumonia. JAMA 245: 1758–1759
Helms CM, Massanari RM, Zeitler R et al. (1983) Legionnaires’ disease associated with a hospital water system: a cluster of 24 nosocomial cases. Ann Intern Med 99: 172–178
Helms CM, Viner JP, Weisenburger DD, Chiu LC, Renner ED, Johnson W (1984) Sporadic Legionnaires’ disease: clinical observations on 87 nosocomial and community-acquired cases. Am J Med Sci 288: 2–12
Hendrickson DA (1985) Reagents and stains. In: Manual of Clinical Microbiology, 4th edn. American Society for Microbiology, Washington DC, pp 1093–1107
Herbrink P, Meenhorst PL, Groothuis DG, Munckhof HV, Bax R, Meijer CJ, Lindeman J (1983) Detection of antibodies against Legionella pneumophila serogroups 1 to 6 and the Leiden-1 strain by micro ELISA and immunofluorescence assay. J Clin Pathol 36: 1246–1252
Hernandez FJ, Kirby BD, Stanley TM, Edelstein PH (1980) Legionnaires’ disease. Postmortem pathologic findings of 20 cases. Am J Clin Pathol 73: 488–495
Hervas JA, Lopez P, De la Fuente A, Alomar P (1988) Multiple organ system failure in an infant with Legionella infection. Pediatr Infect Dis J 7: 671–673
Herwaldt LA, Gorman GW, Hightower AW et al. (1984) Pontiac fever in an automobile engine assembly plant In: Thornsberry C, Balows A, Feeley JC, Jakubowski W, G. Ruckdeschel and W. Ehret (eds) Legionella. Proc 2nd Int Symposium, American Society for Microbiology, Washington DC, pp 246–247
Hillebrand G, Castro LA, Land W, Ruckdeschel G (1982) Legionnaires’ disease following renal transplantation. Transplant Proc 14: 49–50
Hilton E, Freedman RA, Cintron F, Isenberg HD, Singer C (1986) Acid-fast bacilli in sputum: a case of Legionella micdadei pneumonia. J Clin Microbiol 24: 1102–1103
Hiraishi A, Hoshino Y, Kitamura H (1984) Isoprenoid quinone composition in the classification of Rhodospirillaceae. J Gen Appl Microbiol 30: 197–210
Hofflin JM, Potasman J, Baldwin JC, Oyer PE, Stinson EB, Remington JS (1987) Infectious complications in heart transplant recipients receiving cyclosporine and corticosteroids. Ann Intern Med 106: 209–216
Hoffmann PS, Pine L, Bell S (1983) Production of superoxide and hydrogen peroxide in medium used to culture Legionella pneumphila: catalytic decomposition by charcoal. Appl Environ Microbiol 45: 784–791
Hoffman PS, Butler CA, Quinn FD (1989) Cloning and temperature-dependent expression in Escherichia coli of a Legionella pneumophila gene coding for a genus-common 60-kilodalton antigen. Infect Immun 57: 1731–1739
Hoffmann PS, Houston L, Butler CA (1990) Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in Legionella pneumophila-infected HeLa cells. Infect Immun 58: 3380–3387
Holden EP, Winkler HH, Wood DO, Leinbach ED (1984) Intracellular growth of Legionella pneumophila within Acanthamoeba castellanii Neff. Infect Immun 45: 18–24
Holliday MG (1980) The diagnosis of Legionnaires’ disease by counterimmunoelectrophoresis. J Clin Pathol 33: 1174–1178
Holliday OL, Cullis PA, Gilroy J (1982) Motor neuropathy in a patient with Legionnaires’ disease. Ann Neurol 12: 493–494
Holt P (1981) Legionnaires’ disease and abscess of appendix. Br Med J 282: 1035–1036
Hooper TL, Gould FK, Swinburn CR et al. (1988) Ciprofloxacin: a preferred treatment for Legionella infections in patients receiving cyclosporin A. J Antimicrob Chemother 22: 952–953
Horbach I (1991) Comparison of two tests for the detection of Legionella urinary antigen. 6th Meeting of the Euopean Working Group on Legionella Infections. Elsinore, Denmark, May 27–29. Supplementary report
Horbach I, Naumann D, Fehrenbach FJ (1988) Simultaneous infections with different serogroups of Legionella pneumophila investigated by routine methods and Fourier transformation infrared spectroscopy. J Clin Microbiol 26: 1106–1110
Horbach I, Fehrenbach FJ, Jürgens D (1990) An outbreak of Legionnaires’ disease in a West-German hospital. 5. EW GLI-Meeting, Moskau (GSU) 16–18 May
Horbach I, Jürgens D, Fehrenbach FJ (1990) Zur Diagnostik der Legionellose. Bundesgesundheitsblatt 9: 375–379
Horwitz MA (1983) The Legionnaires’ disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med 158: 2108–2126
Horwitz MA (1983) Cell-mediated immunity in Legionnaires’ disease. J Clin Invest 71: 1686–1697
Horwitz MA (1983) Formation of a novel phagosome by the Legionnaires’ disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med 158: 1319–1331
Horwitz MA (1984) Phagocytosis of the Legionnaires’ disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell 36: 27–33
Horwitz MA (1989) The sequestening of legionellae. ASM-News 55: 407–408
Horwitz MA, Maxfield FR (1984) Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol 99: 1936–1943
Horwitz MA, Silverstein SC (1980) Legionnaires’ disease bacterium ( Legionella pneumphila) multiples intracellularly in human monocytes. J Clin Invest 66: 441–450
Horwitz MA, Silverstein SC (1981) Interaction of the Legionnaires’ disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody, and complement. J Exp Med 153: 386–397
Horwitz MA, Silverstein SC (1983) Intracellular multiplication of Legionnaires’ disease bacteria ( Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin. J Clin Invest 71: 15–26
Humayun HM, Bird TJ, Daugirdas JT, Fruin RC, Shawky MM, Ing TS (1981) Legionnaires’ disease bacillus in bone marrow. Can Med Assoc J 125: 1084–1085
Hurter T, Schlegel J, Lorenz J, Rumpelt JH (1990) Persistierende Alveolitis nach Legionella-Pneumonie. Dtsch Med Wochenschr 115: 1188–1192
Israelski DM, Tucker RM, Baldwin JC, Pohlod DJ, Saravolatz LD, Remington JS (1989) Ciprofloxacin for the treatment of endocarditis due to Legionella pneumophila. Rev Infect Dis 2 [suppl 5]: 1203–1204
Jacobs RF, Liesnard C, Goldstein JP, Struelens MJ, Primo G, Leclerc JL, Thys JP (1990) Asymptomatic Legionella pneumophila infections in heart transplant recipients. Transplantation 50: 174–175
Jacox RF, Stuard JD (1978) Legionnaires’ disease in a patient with systemic lupus erythematosus. Arthritis Rheum 21: 976–977
Jensen CWB, Flechner SM, Van Vuren CT, Frazier OH, Cooley DA, Lorber MJ, Kahan BD (1987) Exacerbation of cyclosporine toxicity by concomitant administration of erythromycin. Transplantation 43: 263–270
Johnson DA, Wagner KF, Blanks J, Slater J (1985) False-positive direct fluorescent antibody testing for Legionella. JAMA 253: 40–41
Johnson JD, Raff MJ, Van Arsdall JA (1984) Neurologic manifestations of Legionnaires’ disease. Medicine (Baltimore) 63: 303–310
Johnson PE, Lynch SR, Park CH (1982) Myelosuppression in Legionnaires’ disease. Arch Intern Med 142: 1377–1378
Joly JR, Winn WC Jr (1984) Correlation of subtypes of Legionella pneumophila defined by monoclonal antibodies with epidemiological classification of cases and environmental sources. J Infect Dis 150: 667–671
Jones JL, Hébert GA (eds) (1979) Legionnaires’, the disease, the bacterium, and methodology. Centers for Disease Control, Atlanta.
Jones RN (1991) Activity of sparfloxacin (AT-4140), PD 127391 and PD 131628 against Legionella spp. J Antimicrob Chemother 27: 389–390
Jones RN, Barry AL, Thornsberry C (1983) In vitro evaluation of three new macrolide antibiotic agents, Ru 28965, Ru 29065, and Ru 29702, and comparisons with other orally administered drugs. Antimicrob Agents Chemother 24: 109–215
Jones RN, McDougal LK, Thornsberry C (1984) Inhibition and hydrolysis studies of beta-lactamases found in Legionella species: antimicrobial activity of new macrolides on legionellae. In: Thornsberry C, Balows A, Feeley JC, Jakubowski W (eds) Legionella. Proc 2nd Int Symposium, American Society for Microbiology, Washington DC, pp 100–103
Jalweit WH, Winn WC Jr, Rocco TA Jr, Girod JC (1982) Hemodialysis fistula infections caused by Legionella pneumophila. Ann Intern Med 96: 173–175
Kalz SM, Matus JP (1984) Febrile illness produced in guinea pigs by oral inoculation of Legionella pneumophila. In: Thornsberry C, Balows A, Feeley JC, Jakubowski W (eds) Legionella. Proc 2nd Int Symposium, American Society for Microbiology, Washington DC, pp 124–127
Karr DE, Bibb WF, Moss CW (1982) Isoprenoid quinones of the genus Legionella. J Clin Microbiol 15: 1044–1048
Katz SM, Hashemi S (1982) Electron microscopic examination of the inflammatory response to Legionella pneumophila in guinea pigs. Lab Invest 46: 24–32
Kaufmann AF, McDade JE, Patton CM et al. (1981) Pontiac fever: isolation of the etiologic agent ( Legionella pneumophila) and demonstration of its mode of transmission. Am J Epidemiol 114: 337–347
Keen MG, Hoffman PS (1989) Characterization of a Legionella pneumophila extra-cellular protease exhibiting hemolytic and cytotoxic activities. Infect Immun 57: 732–738
Kessler M (1986) Interaction between cyclosporin and erythromycin in a kidney transplant patient. Eur J Clin Pharmacol 30: 633–634
Khardori N, Haron E, Rolston K (1987) Legionella micdadei pneumonia in the acquired immune deficiency syndrome. Am J Med 83: 600–601
Kilvington S, Price J (1990) Survival of Legionella pneumophila within cysts of Acanthamoeba polyphaga following chlorine exposure. J Appl Bacteriol 68: 519–525
King JW, May JS (1980) Cold agglutinin disease in a patient with Legionnaires’ disease. Arch Intern Med 140: 1537–1538
Kirby BD, Harris AA (1987) Nosocomial Legionnaires’ disease. Semin Respir Infect 2: 255–261
Kirby BD, Peck H, Meyer RD (1979) Radiographic features of Legionnaires’ disease. Chest 76: 562–565
Kirby BD, Snyder KM, Meyer RD, Finegold SM (1980) Legionnaires’ disease: report of sixty-five nosocomially acquired cases and review of the literature. Medicine (Baltimore) 59: 188–205
Kitsukawa K, Hara J, Saito A (1991) Inhibition of Legionella pneumophila in guinea pig peritoneal macrophages by new quinolone, macrolide and other antimicrobial agents. J Antimicrob Chemother 27: 343–353
Klein TW, Newton CA, Blanchard DK, Widen R, Friedman H (1987) Induction of interleukin 1 by Legionella pneumophila antigens in mouse and human mononuclear leukocyte cultures. Zentralbi Bakteriol Mikrobiol Hyg [A] 265: 462–471
Kohler RB, Wheat LJ (1982) Rapid diagnosis of pneumonia due to Legionella pneumophila serogroup 1. J Infect Dis 146: 444
Kohler RB, Zimerman SE, Wilson E, Allen SD, Edelstein PH, Wheat LJ, White A (1981) Rapid radioimmunoassay diagnosis of Legionnaires’ disease: detection and partial characterization of urinary antigen. Ann Intern Med 94: 601–605
Kohler RB, Winn WC Jr, Wheat LJ (1984) Onset and duration of urinary antigen excretion in Legionnaires’ disease. J Clin Microbiol 20: 605–607
Kohler RB, Wheat LJ, French ML, Meenhorst PL, Winn WC Jr, Edelstein PH (1985) Cross-reactive urinary antigens among patients infected with Legionella pneumophila serogroups 1 and 4 and the Leiden 1 strain. J Infect Dis 152: 1007–1012
Kohler RB, Wilde C 3rd., Johnson W, Joly J, Wheat LJ, Baker R, Misfeldt M (1988) Immunologic diversity among serogroup 1 Legionella pneumophila urinary antigens demonstrated by monoclonal antibody enzyme-linked immunosorbent assays. J Clin Microbiol 26: 2059–2063
Kohne DE, Steigerwalt AG, Brenner DJ (1984) Nucleic acid probe specific for members of the genus Legionella. In: Thornsberry C, Balows A, Feeley JC, Jakubowski W (eds) Legionella. Proceedings of the 2nd International Symposium. Washington DC, American Society for Microbiology, pp 107–108
Kohorst WR, Schonfeld SA, Macklin JE, Whitcomb ME (1983) Rapid diagnosis of Legionnaires’ disease by bronchoalveolar lavage. Chest 84: 186–190
Korvick J, Yu VL (1988) Simultaneous infection with Cryptococcus neoformans and Legionella pneumophila. In vivo expression of common defects in cell-mediated immunity. Respiration 53: 132–136
Kovatch AL, Jardine DS, Dowling JN, Yee RB, Pasculle AW (1984) Legionellosis in children with leukemia in relapse. Pediatrics 73: 811–815
Kroboth FJ, Yu VL, Reddy S, Yu AC (1983) Clinicoradiographic correlations with the extent of Legionnaires’ disease. AJR 141: 263–268
Kugler JW, Armitage JO, Helms CM et al. (1983) Nosocomial Legionnaires’ disease occurence in recipients of bone marrow transplants. Am J Med 74: 281–288
Kundsin RB, Walter CW (1988) Legionella prosthetic-valve endocarditis. N Engl J Med 319: 581
Kurz RW, Graninger W, Egger T, Pichler H, Tragl KH (1988) Failure of treatment of legionella pneumonia with ciprofloxacin. J Antimicrob Chemother 22: 389–391
Kusne S, Dummer JS, Singh N et al. (1988) Infections after liver transplantation. An et al. analysis of 101 consecutive cases. Medicine (Baltimore) 67: 132–143
L’age M, Horbach I, Ulmrich W, Weyer H, Fehrenbach FJ (1983) Legionärskrankheit bei einer Inland-Reisegruppe. Dtsch Med Wochenschr 108: 288–292
Lake KB, Van Dyke JJ, Gerberg E, Browne PM (1979) Legionnaires’ disease and pulmonary cavitation. Arch Intern Med 139: 485–486
Landau Z, Konichesky S, Boxemboim P, Eisenberg E, Bentwich Z (1989) Pefloxacin as therapy for Legionnaires’ disease. Rev Infect Dis 11 [suppl]:S 1141
Landes BW, Pogson GW, Beauchamp GD, Skillman RK, Brewer JH (1982) Pericarditis in a patient with Legionnaires’ disease. Arch Intern Med 142: 1234–1235
Langhoff E, Madsen S (1983) Rapid metabolism of cyclosporine and prednisone in kidney transplant patients receiving tuberculostatic treatment. Lancet 2: 1031
Lattimer GL, Cepil BA (1980) Legionnaires’ disease serology. Effect of antigen preparation on specificity and sensitivity of the indirect fluorescent antibody test. J Clin Pathol 33: 585–590
Lattimer GL, McCrone C, Galgon J (1978) Diagnosis of Legionnaires’ disease from transtracheal aspirate by direct fluorescent-antibody staining and isolation of the bacterium. N Engl J Med 299: 1172–1173
Laussucq S, Schuster D, Alexander WJ, Thacker WL, Wilkinson HW, Spika JS (1988) False-positive DNA probe test for Legionella species associated with a cluster of respiratory illnesses. J Clin Microbiol 26: 1442–1444
Lavocat MP, Berthier JC, Rousson A, Bornstein N. Hartemann E (1987) Legionellose pulmonaire chez un enfant apres noyade en eau douce. Press Med 16: 780
Lawson JH (1978) Legionnaires’ disease — the Benidorm episode. Scott Med J 23: 121–124
Leland DS, Kohler RB (1991) Evaluation of the L-CLONE Legionella pneumophila serogroup 1 urine antigen latex test. J Clin Microbiol 29: 2220–2223
Leroy O, Benscart C, Chidiac C, Sivery B, Senneville E, Vincent-du-Laurier M, Mouton Y (1989) Traitement des pneumonies dues aux legionelles, myoplasmes, Clamydiae et rickettsies par l’ofloxacine. Pathol Biol (Paris) 37: 1137–1140
Lewin S, Brettman LR, Goldstein EJ et al. (1979) Legionnaires’ disease: a cause of severe abscess-forming pneumonia. Am J Med 67: 339–342
Lewis VJ, Thacker WL, Shepard CC, McDade JE (1978) In vivo susceptibility of the Legionnaires’ disease bacterium to ten antimicrobial agents. Antimicrob Agents Chemother 13: 419–422
Liebers DM, Baltch AL, Smith RP, Hammer MC, Conroy JV (1989) Susceptibility of Legionella pneumophila to eight antimicrobial agents including four macrolides under different assay conditions. J Antimicrob Chemother 23: 37–41
Lightfoot NF, Richardson IR, Shrimanker J, Farrell DJ (1991) Post-mortem isolation of legionella due to contamination (letter). Lancet 1: 376
Lind K, Collins MT, Aalund 0 (1984) Comparison of a micro-agglutination test and the indirect immunoflurescence test for Legionella antibodies in patients. Acta Pathol Microbiol Immunol Scand [B] 92: 195–199
Littrup P, Madsen JK, Lind K (1987) Aortic valve endocarditis associated with Legionella infection after Mycoplasma pneumonia. Br Heart J 58: 431–436
Liu F, Wright DN (1984) Gram stain in Legionnaires’ disease. Am J Med 77: 549–550
Lochner JE, Friedman RL, Bigley RH, Iglewski BH (1983) Effect of oxygen-dependent antimicrobial systems on Legionella pneumophila. Infect Immun 39: 487–489
Lode H, Kemmerich B, Schäfer H. Grothe R, Hartmann R, Ehret W, Ruckdeschel G (1987) Significance of non-pneumophila Legionella species in adult community-acquired and nosocomial pneumonia. Klin Wochenschr 65: 463–468
Lowry PW, Blankenship RJ,Gridley W, Troup NJ, Tompkins LS (1991) A cluster of Legionella sternal-wound infections due to postoperative topical exposure to contaminated tap water. N Engl J Med 324: 109–113
Lück PC, Helbig JH, Wunderlich E, Foelske H, Selbitschka M, Wenzel D, Patzold L, Witzleb W (1989) Isolation of Legionella pneumophila serogroup 3 from pericardial fluid in a case of pericarditis. Infection 17: 388–390
Mackenzie C (1987) Communication disorders in Legionnaires’ disease. Br J Disord Commun 22: 253–262
Macrae AD, Greaves PW, Platts P (1979) Isolation of Legionella pneumophila from blood culture. Br Med J 2: 1189–1190
Mahbubani MH, Bej AK, Miller R, Haff L, DiCesare J, Atlas RM (1990) Detection of Legionella with polymerase chain reaction and gene probe methods. Mol Cell Probes 4: 175
Maher WE, Plouffe JF, Para MF (1983) Plasmidprofiles of clinical and environmental isolates of legionella pneumophila serogroup 1. J Clin Microbiol 18: 1422–1423
Maiwald M, Zöller L (1991) Möglichkeiten and Grenzen der Polymerase-Kettenreaktion in der bakteriologischen Diagnostik. Klin Lab 37: 194–200
Marrie TF, Martin RS (1988) Persistent Legionella pneumophila bacteraemia in an immunocompromised host. J Infect 16: 203–204
Marshall W, Foster RS, Winn WC Jr (1981) Legionnaires’ disease in renal transplant patients. Am J Surg 141: 423–429
Martell R, Heinrichs D, Stiller CR, Jenner M, Keown PA, Dupre J (1986) The effects of erythromycin in patients treated with cyclosporine. Ann Intern Med 104: 660–661
Martin RS, Marrie TJ, Best L, Sumarah RK, Peppard R (1984) Isolation of Legionella pneumophila from the blood of a patient with Legionnaires’ disease. Can Med Assoc J 131: 1085–1087
Martiny H, Seidel K, Ruden H (1989) Anwendung von UV-Strahlen zur Desinfektion von Wasser. III. Mitteilung: UV-Sensibilität von Legionella pneumophila unter-schiedlichen Alters in kaltem and warmem Trinkwasser. Zentralbl Hyg Umweltmed 188: 35–46
Mathys W, Junge E, Sobek-Pfeiffer C, Bosenberg H, Von Eiff M (1988) The importance of different laboratory methods in legionella diagnosis in medical care. Zentralbl Bakteriol Mikrobiol Hyg [A] 270: 122–130
Maycock R, Skale B, Kohler RB (1983) Legionella pneumophila pericarditis proved by culture of pericarditis fluid. Am J Med 75: 534–536
McCabe RS, Baldwin JC, McGregor CA, Miller DC, Vosti KL (1984) Prosthetic valve endocarditis by Legionella pneumophila. Ann Intern Med 100: 525–527
McDade JE, Shepard CC, Fraser DW, Tsai TF, Redus MA, Dowdle WR (1977) Legionnaires’ disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 297: 1197–1203
McDonell MT, Colwell RR (1987) The nucleotide sequence of the 5S rRNA from Legionella pneumophila. Nucleic Acids Res 15: 1335
McFarlane JT, Finch RG, Ward MJ, Macrae AD (1982) Hospital study of adult community-acquired pneumonia. Lancet 2: 255–258
McFarlane JT, Miller AC, Roderick-Smith WH, Morris AH, Rose DH (1984) Comparative radiographic features of community-acquired Legionnaires’ disease, pneumococcal pneumonia, mycoplasma pneumonia, psittacosis. Thorax 39: 28–33
McKellar PP (1985) Treatment of community-acquired pneumonias. Am J Med 79: 25–31
McKinney RM (1985) Diagnosis: direct immunofluorescent antibody test. In: Legionellosis 2. Moriber Katz S (ed.) CRC Press, Boca Raton, Florida, USA, pp 23–32
Meletis J, Arlet G, Dournon E et al. (1987) Legionnaires’ disease after bone marrow transplantation. Bone Marrow Transplant 2: 307–313
Mellado A, Aguero J, Seoane A, Rodriguez-Solorzano LM (1986) Plasmid profiles of Legionella pneumophila strains isolated in Spain. Eur J Epidemiol 2: 63–66
Meyer RD (1983) Legionella infections: a review of five years of research. Rev Infect Dis 5: 258–278
Mikesell P, Ezzell JW, Hudson GB (1981) Isolation of plasmids in Legionella pneumophila and Legionella-like organisms. Infect Immun 31: 1270–1272
Miller AC (1979) Early clinical differentiation between Legionnaires’ disease and other sporadic pneumonias. Ann Intern Med 90: 526–528
Millunduck EW, Floyd J, Blanks J (1981) Legionnaires’ disease in an immunologically normal child. Am J Dis Child 135: 1065–1066
Mintz CS, Chen JX, Shuman HA (1988) Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes. Infect Immun 56: 1449–1455
Mody CH, Paine R, Simon R, Toews GB (1989) Legionella pneumophila replicates in alveolar type II cells. Clin Res 37: 480A
Monforte R, Estruch R, Vidal J, Cervera R, Urbano-Marquez A (1988) Delayed seroconversion in Legionnaires’ disease. Lancet 2: 513
Moore EH, Webb WR, Gamsu G, Golden JA (1984) Legionnaires’ disease in the renal transplant patient: Radiology 153: 589–593
Morrill WE, Barbaree JM, Fields BS, Sanden GN, Martin WT (1990) Increased recovery of Legionella micdadei and Legionella bozemanii on buffered charcoal yeast extract agar supplemented with albumin. J Clin Microbiol 28: 616–618
Moss CW (1981) Gas-liquid chromatography as an analytical tool in microbiology. J Chromatogr 203: 337–347
Moss CW, Weaver RE, Dees SB, Cherry WB (1977) Cellular fatty acid composition of isolates from Legionnaires’ disease. J Clin Microbiol 6: 140–143
Moss CW, Kai A, Lambert MA, Patton C (1984) Isoprenoid quinone content and cellular fatty acid composition of Campylobacter species. J Clin Microbiol 19: 772–776
Motte S, Jacobs F, Thys JP, Seoruys E, Gelin M, Adler M (1988) Legionella pneumonia treated with imipenem. Diagn Microbiol Infect Dis 9: 65–66
Muder RR, Yu VL, Vickers RM, Rihs J, Shonnard J (1983) Simultaneous infection with Legionella pneumophila and Pittsburgh pneumonia agent — clinical feature and epidemiological implications. Am J Med 74: 609–614
Muder R, Reddy S, Yu VL, Kroboth FJ (1984) Pneumonia caused by Pittsburgh pneumonia agent: radiologic manifestations. Radiology 150: 633–637
Muder RR, Yu VL, Woo AH (1986) Mode of transmission of Legionella pneumophila. A critical review. Arch Intern Med 146: 1607–1612
Muder RR, Yu VL, Parry MF (1987) The radiologic manifestations of legionella pneumonia. Semin Respir Infect 2: 242–254
Muder RR, Yu VL, Fang GD (1989) Community-acquired Legionnaires’ disease. Semin Respir Infect 4: 32–39
Muldoon RL, Jaecker MS, Kiefer HK (1981) Legionnaires’ disease in children. Pediactrics 67: 329–332
Müller E, Knoch M, Holtermann W, Lennartz H (1989) ARDS bei LegionellenPneumonie — erfolgreiche Behandlung mit dem extrakorporalen CO2-Eliminationsverfahren. Anästh Intensivther Nofallmed 24: 177–180
Müller HE (1983) Häufigkeit der Legionärskrankheit and Infektion durch Leitungswasser. Hyg Med 8: 45
Myerowitz RL, Pasculle AW, Dowling JN et al. (1979) Opportunistic lung infection due to „Pittsburgh Pneumonia Agent,,. N Engl J Med 301: 959–961
Nagington J, Wreghitt TG, Tobin JO, Macrae AD (1979) The antibody response in Legionnaires’ disease. J Hyg (London) 83: 377–381
Naot Y, Brown A, Elder EM, Shonnard J, Luft BJ, Remington JS (1982) IgM and IgG antibody response in two immunosuppressed patients with Legionnaires’ disease. Evidence of reactivation of latent infection. Am J Med 73: 791–794
Nash TW, Libby D, Horwitz MA (1984) Interaction between the Legionnaires’ disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. J Clin Invest 74: 771–782
Nelson DP, Rensimer ER, Burke CM, Raffin TA (1984) Cardiac legionellosis. Chest 86: 807–808
Newsome AL, Baker RL, Miller RD, Arnold RR (1985) Interactions between Naegleria fowleri and Legionella pneumophila. Infect Immun 50: 449–452
Nigro G, Pastoris MC, Fantasia MM, Midulla M (1983) Acute cerebellar ataxia in pediatric legionellosis. Pediatrics 72: 847–849
Nolte FS, Conlin CA, Roisin AJ, Redmond SR (1984) Plasmids as epidemiological markers in nosocomial Leginnaires’ Disease. J Infect Dis 149: 251–256
Nolte FS, Conlin CA, Motley MA (1986) Electrophoretic and serological characterization of the lipopolysaccharides of Legionella pneumophila. Infect Immun 52: 676–681
Nomura S, Hatta K, Iwata T, Aihara M (1989) Legionella pneumophila isolated in pure culture from the ascites of a patient with systemic lupus erythematosus. Am J Med 86: 833–834
Nordström K, Kallings J, Dahnsjö H, Clemens F (1983) An outbreak of Legionnaires’ disease in Sweden: report of sixty-eight cases. Scand J Infect Dis 15: 43–55
Nowicki M, Paucod JC, Bornstein N, Meugnier H, Isoard P, Fleurette J (1988) Comparative efficacy of five antibiotics on experimental airborne legionellosis in guinea pigs. J Antimicrob Chemother 22: 513–519
Nunniuk JC, Gallagher JG, Yates JW (1986) Legionnaires’ disease in patients with cancer. Med Pediatr Oncol 14: 81–85
Oldham LJ, Rodgers RG (1985) Adhesion, penetration and intracellular replication of Legionella pneumophila: an in vitro model of pathogenesis. J Gen Microbiol 131: 697–706
Orenstein WA, Overturf GD, Leedom JM et al. (1981) The frequency of Legionella infection prospectively determined in children hospitalized with pneumonia. J Pediatr 99: 403–406
Orrison LH, Bibb WF, Cherry WB, Thacker WL (1983) Determination of antigenic relationships among legionellae and non-legionellae by direct fluorescent-antibody and immunodiffusion tests. J Clin Microbiol 17: 332–337
Osterholm MT, Chin TD, Osborne DO et al. (1983) A 1957 outbreak of Legionnaires’ disease associated with a meat packaging plant. Am J Epidemiol 117: 60–67
O’Mahony MC, Stanwell-Smith RE, Tillett HE et al. (1990) The Stafford outbreak of Legionnaires’ disease. Epidemiol Infect 104: 361–380
Parker MM, Macher AM, Shelhamer JH, Balow JE, Gill V, Parrillo JE (1983) Unresponsiveness of Legionella bozemanii pneumonia to erythromycin administration despite in vitro sensitivity. Am Rev Respir Dis 128: 955–956
Pasculle AW, Dowling JN, Weyant RS, Sniffen JM, Cordes LG, Gorman GM, Feeley JC (1981) Susceptibility of Pittsburgh pneumonia agent ( Legionella micdadei) and other newly recognized members of the genus Legionella to nineteen antimicrobial agents. Antimicrob Agents Chemother 20: 793–799
Pasculle AW, Veto GE, Krystofiak S, McKelvey K, Vrsalovic K (1989) Laboratory and clinical evaluation of a commercial DNA probe for the detection of Legionella spp.. J Clin Microbiol 27: 2350–2358
Pastoris MC, Ciarrhocchi S, Di-Capua A, Temperanza AM (1984) Comparison of phenol-and heat-killed antigens in the indirect immunofluorescence test for serodiagnosis of Legionella pneumophila group 1 infections. J Clin Microbiol 20: 780–783
Pau CP, Plikaytis BB, Carlone GM, Warner IM (1988) Purification, partial characterization, and seroreactivity of a genuswide 60-kilodalton Legionella protein antigen. J Clin Microbiol 26: 67–71
Pavy MD, Johnson AH (1981) Possible recurrence of Legionnaires’ disease. South Med J 74: 997–999
Paya CV, Hermans PE, Washington JA II., Smith TF, Anhalt JP, Wiesner RH, Krom RAF (1989) Incidence, distribution, and outcome of episodes of infection in 100 orthotopic liver transplantations. Mayo Clin Proc 64: 555–564
Payne NR, Horwitz MA (1987) Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. J Exp Med 166: 1377–1389
Pearlman E, Jiwa AH, Engleberg NC, Eisenstein BI (1988) Growth of Legionella pneumophila in a human macrophage-like (U937) cell line. Microbiol Pathogen 5: 87–95
Peerless AG, Liebhafter M, Anderson S, Lehrer R, Stiehm ER (1985) Legionella pneumonia in chronic granulomatous disease. J Pediatr 106: 783–785
Peliowsky A, Finer NN (1986) Intractable seizures in Legionnaires’ disease. J Pediatr 109: 657–658
Peterson PK, Ferguson R, Fryd DS, Balfour HH Jr, Rynasiewicz J, Simmons RL (1982) Infectious diseases in hospitalized renal transplant recipients: a prospective study of a complex and evolving problem. Medicine (Baltimore) 61: 360–372
Pine L, George JR, Reeves MW, Harrell WK (1979) Development of a chemically defined liquid medium for growth of Legionella pneumophila. J Clin Microbiol 9: 615–626
Pine L, Hoffman PS, Malcolm GB, Benson RF, Gorman GW (1984) Whole-cell peroxidase test for identification of Legionella pneumophila. J Clin Microbiol 19: 286–290
Pine L, Hoffman PS, Malcolm GB, Benson RF, Keen MG (1984) Determination of catalase, peroxidase, and superoxide dismutase within the genus Legionella. J Clin Microbiol 20: 421–429
Pine L, Hoffman PS, Malcolm GB, Benson RF, Franzus MJ (1986) Role of keto acids and reduced-oxygen-scavenging enzymes in the growth of Legionella species. J Clin Microbiol 23: 33–42
Platzek C, Förster EC, Schneider MV et al. (1990) Enzephalitis bei Legionella bozemanii-Pneumonie. Dtsch Med Wochenschr 115: 1956–1959
Plouffe JF, Para MF, Maher WE, Hackman B, Webster L (1983) Subtypes of Legionella pneumophila serogroup 1 associated with different attack rates. Lancet 2: 649–650
Pohlod DJ, Saravolatz LD, Quinn EL, Somerville MM (1980) Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila. Antimicrob Agents Chemother 18: 353–354
Pohlod DJ, Saravolatz LD, Somerville MM (1988) Inhibition of Legionella pneumophila multiplication within human macrophages by fleroxacin. J Antimicrob Chemother 22 [suppl D]: 49–54
Pokrovskii VI, Prozorovskii SV, Tartakovskii IS, Belen’kii SN, Akulov KN (1988) An outbreak of Legionella infection in Armavire. Zh Mikrobiol Epidemiol Immunobiol 10: 24–27
Posner MR, Candill MA, Brass R, Ellis E (1980) Legionnaires’ disease associated with rhabdomyolysis and myoglobinuria. Arch Intern Med 140: 848–850
Potasman J, Liberson A, Krimerman S (1990) Legionella infection mimicking herpes encephalitis. Crit Cerc Med 18: 453–454
Poulter N, Gabriel R, Porter KA, Bartlett C, Kershaw M, McKendrick GD, Venkataraman R (1981) Acute interstitial nephritis complicating Legionnaires’ disease. Clin Nephrol 15: 216–220
Pounder DJ (1983) Warthin-Starry for Legionella. Am J Clin Pathol 80: 276
Power KJ, Bowen DJ (1986) Intensive care aspects of severe Legionella pneumonia. Anaesthesia 41: 620–622
Raffi F, Mahe M, Caillon J, Grolleau JY (1988) Maladie des legionnaires avec agranulocytose devolution favorable. Presse Med 17: 649
Rand KH, Pollard RB, Merigan TC (1978) Increased pulmonary superinfection in cardiac transplant patients undergoing primary cytomegalovirus infection. N Engl J Med 298: 951–953
Randolph KA, Beckman JH (1979) Legionnaires’ disease presenting with empyema. Chest 75: 404 406
Rechnitzer C, Tvede M, Döring G (1989) A rapid method for purification of homogeneous Legionella pneumophila cytotoxic protease using fast protein liquid chromatography. FEMS Microbiol Lett 59: 39–44
Redd SC, Lin FY, Fields BS et al. (1990) A rural outbreak of Legionnaires’ disease linked to visiting a retail store. Am J Public Health 80: 431–434
Redd SC, Schuster DM, Quan J, Plikaytis BD, Spika JS, Cohen ML (1988) Legionellosis in cardiac transplant recipients: results of a nationwide survey. J Infect Dis 158: 651–653
Reid D, Grist NR, Najera R (1978) Illness associated with „package tours,,: a combined Spanish-Scottish study. Bull WHO 56: 117–122
Reingold AL (1988) Role of legionellae in acute infections of the lower respiratory tract. Rev Infect Dis 10: 1018–1028
Reingold AL, Thomason BM, Brake BJ, Thacker WL, Wilkinson HW, Kuritsky JN (1984) Legionella pneumonia in the United States: the distribution of serogroups and species causing human illness. J Infect Dis 149: 819
Reisenleiter M, Linassier C, Colombat P, Lemaire B, Lamagnere JP (1988) Legionellose au cours d’une leucemie a tricholeucocytes. Presse Med 17: 1541
Reitano M, Engler HD, Bottone EJ (1988) Legionella pneumophila: initial detection through evaluation of Giemsa-stained smears of a bronchial aspirate. Diagn Microbiol Infect Dis 10: 125–129
Renner ED, Helms CM, Hierholzer WJ Jr et al. (1979) Legionnaires’ disease in pneumonia patients in Iowa: a retrospective seroepidemiologic study, 1972–1977. Ann Intern Med 90: 603–606
Richards NC, McKinley KP (1989) A severe case of Legionnaires’ disease connected to the BBC outbreak in 1988. J R Nay Med Sery 75: 117–120
Riggs SA, Wray NP, Waddell CC, Rossen RD, Gyorkey F (1982) Thrombotic thrombocytopenic purpura complicating Legionnaires’ disease. Arch Intern Med 142: 2275–2280
Rihs JD, Yu VL, Zuravlett JJ, Gretz A, Muder RR (1985) Isolation of Legionella pneumophila from blood with the BACTEC system: a prospective study yielding positive results. J Clin Microbiol 22: 422–424
Rodgers FG, Greaves PW, Macrae AD, Lewis MJ (1980) Electron microscopic evidence of flagella and pili on Legionella pneumophila. J Clin Pathol 33: 1184–1188
Rodgers FG, Macrae AD (1979) Immunoferritin electronmicroscopy in legionellosis. Lancet 1: 786
Rodgers FG, Oldham LJ (1984) Glycocalyx and ruthenium red labeling of Legionella pneumophila. J Clin Microbiol 20: 1228–1229
Rodgers FG, Pasculle AW (1991) Legionella. In: Manual of Clinical Microbiology, 5th edn. American Society for Microbiology, Washington DC, pp 442–453
Rolstad B, Berdal BP (1981) Immune defenses against Legionella pneumophila in rats. Infect Immun 32: 805–812
Rosmini F, Castellani-Pastoris M, Mazzotti MF et al. (1984) Febrile illness in successive cohorts of tourists at a hotel on the Italian Adriatic coast: evidence for a persistent focus of Legionella infection. Am J Epidemiol 119: 124–134
Rowbotham TJ (1981) Preliminary report on the pathogenicity of Legionella pneumophila for fresh-water and soil amoebae. J Clin Pathol 33: 1179–1183
Rowbotham TJ (1983) Isolation of Legionella pneumophila from clinical specimens via amoebae, and the interaction of those and other isolates with amoebae. J Clin Pathol 36: 978
Rubin RH, Tolkoff-Rubin NE (1988) Opportunistic infections in renal allograft-recipients. Transplant Proc 20: 12–18
Ruckdeschel G, Ehret W, Ahl A (1984) Susceptibility of Legionella spp. to imipenem and 27 other 1:1-lactam antibiotics. Eur J Clin Microbiol Infect Dis 3: 463–467
Ruckdeschel G, Ehret W, Ahl A (1984) Susceptibility of Legionella spp. to quinolone derivatives and related organic acids. Eur J Clin Microbiol Infect Dis 3: 373
Ruckdeschel G, Klammert R, Ehret W (1990) Untersuchungen zur Empfindlichkeit von Legionellen gegen Makrolide. Fortschr Antimikr Chemother 91: 65–74
Ruf B, Schürmann D, Horbach J, Seidel K, Pohle HD (1988) Nosocomial legionella pneumonia: demonstration of potable water as the source of infection. Epidemiol Infect 101: 647–654
Ruf B, Schürmann D, Horbach I, Fehrenbach FJ, Pohle HD (1990) Prevalence and diagnosis of Legionella pneumonia: a 3-year prospective study with emphasis on application of urinary antigen detection. J Infect Dis 162: 1341–1348
Ryan ME, Feldman S, Pruitt B, Fraser DW (1979) Legionnaires’ disease in a child with cancer. Pediatrics 64: 951–953
Saito A, Sawatari K, Fukuda Y et al. (1985) Susceptibility of Legionella pneumophila to ofloxacin in vitro and experimental Legionella pneumonia in guinea pigs. Antimicrob Agents Chemother 28: 15–20
Saito A, Koga H, Shigeno H et al. (1986) The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs. J Antimicrob Chemother 18: 251–260
Sampson JS, Wilkinson HW, Tsang VC, Brake BJ (1983) Kinetic-dependent enzyme-linked immunosorbent assay for detection of antibodies to Legionella pneumophila. J Clin Microbiol 18: 1340–1344
Saravolatz LD, Burch KH, Fisher E, Madhavan T, Kiani D, Neblett T, Quinn EL (1979) The compromised host and Legionnaires’ disease. Ann Intern Med 90: 533–537
Saravolatz LD, Pohlod DJ, Quinn EL (1979) In vitro susceptibility of Legionella pneumophila, sergroups I—IV. J Infect Dis 140: 251
Sathapatayavongs B, Kohler RB, Wheat LJ, White A, Winn WC Jr (1983) Rapid diagnosis of Legionnaires’ disease by latex agglutination. Am Rev Respir Dis 127: 559–562
Sathapatayavongs B, Kohler RB, Wheat LJ, White A, Winn WC Jr, Girod JC, Edelstein PH (1982) Rapid diagnosis of Legionnaires’ disease by urinary antigen detection. Comparison of ELISA and radioimmunoassay. Am J Med 72: 576–582
Schianger G, Lutwick LI, Kurzman M, Hoch B, Chandler FW (1984) Sinusitis caused by Legionella pneumophila in a patient with the aquired immune deficiency syndrome. Am J Med 77: 957–960
Schmidt T, Pfeiffer A, Ehret W, Keiditsch E, Ruckdeschel G, Kaess H (1989) Legionella infection of the colon presenting as acute attack of ulcerative colitis. Gastroenterology 97: 751–755
Schoenen D, Schulze-Röbbecke R, Schirdewahn N (1988) Mikrobielle Kontamination von Wasser durch Rohr-und Schlauchmaterialien. 2. Mitteilung: Wachstum von Legionella pneumophila. Zentralbl Bakteriol Mikrobiol Hyg [B] 186: 326–332
Schönwald S, Gunjaca M, Kolacny-Babic L, Car V, Gosev M (1990) Comparison of azithromycin and erythromycin in the treatment of atypical pneumonias. J Antimicrob Chemother 25 [Suppl A]: 123–126
Schulze-Röbbecke R, Jung KD, Pullmann H, Hundgeburth J (1990) Sanierung eines mit Legionella pneumophila kontaminierten Krankenhaus-Warmwassersystems. Zentralbl Hyg Umweltmed 190: 84–100
Schürmann D, Ruf B, Pfannkuch F, Horbach J, Pohle HD (1988) Fatal legionellosis in patients with malignant hematologic diseases. Blut 56: 27–31
Seidel K, Börnert W, Bäz G, Blenkenburg A, Alexander I (1986) Vorkommen von Legionella pneumophila in Grundwasser sowie kalten und warmen Trinkwässern. Vom Wasser 67: 39–48
Senecal JL, St. Antoine P, Beliveau C (1987) Legionella pneumophila lung abscess in a patient with systemic Lupus erythematosus. Am J Med 293:309–314
Sharrar RG, Friedman HM, Miller WT, Yanak MJ, Abrutyn E (1979) Summertime pneumonias in Philadelphia in 1976. An epidemiologic study. Ann Intern Med 90: 577–580
Simpson RM, Cogswell JJ, Mitchell ER (1980) Legionnaires’ disease in an infant. Lancet 2: 2740–2741
Skrobot BJ, Gillen JC, Rudisill JR, John PG (1986) Recurrent legionnaires’ disease: a case report. Fam Pract Res J 6: 67–71
Soper DE, Melone PJ, Conover WB (1986) Legionnaires’ disease complicating pregnancy. Obstet Gynecol 67: 10S - 12S
Soriano F, Aguilar L, Gomez-Garces JL (1982) Simple immunodiffusion test for detecting antibodies against Legionella pneumophila serotype 1. J Clin Microbiol 15: 330–331
Spano C, Menozzi M (1982) Legionnaires’ disease in Palermo and possible involvement of Legionella pneumophila in cases of pericardial effusion (letter). Infection 10: 103–104
Stanwick RS (1986) Balancing the risks: Legionella pneumophila and tap water scalds in the home. Can Med Assoc J 135: 1251–1252
Starnbach MN, Falkow S, Tompkins LS (1989) Species-specific detection of Legionella pneumophila in water by DNA amplification and hybridization. J Clin Microbiol 27: 1257–1261
Steinmetz I, Rheinheimer C, Hubner I, Bitter-Suermann D (1991) Genus-specific epitope on the 60-kilodalton legionella heat shock protein recognized by a monoclonal antibody. J Clin Microbiol 29: 346–354
Stiehm ER, Chin TW, Haas A, Peerless AG (1986) Infectious complications of the primary immunodeficiencies. Clin Immunol Immunopathol 40: 69–86
Stokes DH, Slocombe B, Sutherland R (1989) Bactericidal effects of amoxycillin/clavulanic acid against Legionella pneumophila. J Antimicrob Chemother 23: 43–51
Storch GA, Sagel SS, Baine WB (1981) The chest roentgenogram in sporadic cases of Legionnaires’ disease. JAMA 245: 587–590
Stout JE, Yu VL, Vickers RM, Shonnard J (1982) Potable water supply as the hospital reservoir for Pittsburgh pneumonia agent. Lancet 1: 471–472
Stout JE, Yu VL, Vickers RM et al. (1982) Ubiquitousness of Legionella pneumophila in the water supply of a hospital with endemic Legionnaires’ disease. N Engl J Med 306: 466–468
Stout JE, Best M, Yu VL, Rihs JD (1986) A note on symbiosis of Legionella pneumophila and Tatlockia micdadei with human respiratory flora. J Appl Bacteriol 60: 297–299
Stout JE, Joly J, Para M, Plouffe J, Ciesielski C, Blaser MJ, Yu VL (1988) Comparison of molecular methods for subtyping patients and epidemiologically linked environmental isolates of Legionella pneumophila. J Infect Dis 157: 486–495
Strikas R, Seifert MR, Lentino JR (1983) Autoimmune hemolytic anemia and Legionella pneumophila pneumonia. Ann Intern Med 99: 345
Sturm R, Staneck JL, Myers JP (1981) Pediatric Legionnaires’ disease: diagnosis by direct immunofluorescent strains of sputum. Pediatrics 68: 539–543
Svendsen JH, Jonsson V, Niebuhr U (1987) Combined pericarditis and pneumonia caused by Legionella infection. Br Heart J 58: 663–664
Tang PW, Toma S (1986) Broad-spectrum enzyme-linked immunosorbent assay for detection of Legionella soluble antigens. J Clin Microbiol 24: 556–558
Tatlock H (1982) Classification of the cause of Fort Bragg fever (pretibial fever). Rev Infect Dis 4: 157–158
Tenover FC, Edelstein PH, Goldstein LC, Sturge JC, Plorde JJ (1986) Comparison of cross-staining reactions by Pseudomonas spp. and fluorescein-labeled polyclonal and monoclonal antibodies directed against Legionella pneumophila. J Clin Microbiol 23: 647–649
Thacker SB, Bennett JV, Tsai TF et al. (1978) An outbreak in 1965 of severe respiratory illness caused by the Legionnaires’ disease bacterium. J Infect Dis 138: 512–519
Thacker WL, Benson RF, Staneck JL, Vincent SR, Mayberry WR, Brenner DJ, Wilkinson HW (1988) Legionella cincinnatiensis sp. nov. isolated from a patient with pneumonia. J Clin Microbiol 26: 418–420
Thacker WL, Plikaytis BB, Wilkinson HW (1985a) Identification of 22 Legionella species and 33 serogroups with the slide agglutination test. J Clin Microbiol 21: 779–782
Thomason BM, Chandler FW, Hollis DG (1979) Flagella on Legionnaires’ disease bacteria: an interim report. Ann Intern Med 91: 224–226
Thomason BM, Harris PP, Hicklin MD, Blackman JA, Moss CW, Matthews FA (1979) A legionella-like bacterium related to WIGA in a fatal pneumonia. Ann Intern Med 91: 673–676
Thompson TA, Wilkinson HW (1982) Evaluation of a solid-phase immunofluorescence assay for detection of antibodies to Legionella pneumophila. J Clin Microbiol 16: 202–204
Thornsberry C, Kirven LA (1978) Beta-lactamase of Legionnaires’ bacterium. Curr Microbiol 1: 51–54
Thornsberry C, Baker CN, Kirven LA (1978) In vitro activity of antimicrobial agents on Legionnaires’ disease bacterium. Antimicrob Agents Chemother 13: 78–80
Tison DL, Pope DH, Cherry WB, Fliermans CB (1981) Growth of Legionella pneumophila in association with bluegreen algae. Appl Environ Microbiol 39: 456–459
Tobin JO, Beare J, Dunnill MS et al. (1980) Legionnaires’ disease in a transplant unit: isolation of the causative agent from shower baths. Lancet 2: 118–121
Tompkins LS, Rossler BJ, Redd SC, Markowitz LE, Cohen ML (1988) Legionella prosthetic valve-endocarditis. N Engl J Med 318: 530–535
Traub WH, Spohr M (1984) In vitro antibiotic susceptibility of legionellaceae: search for alternative antimicrobial drugs. Chemother 30: 182–187
Troup N, Morton A, Munro S et al. (1990) Comparison of genus specific immunofluorescent reagent with culture for detection of Legionella. American Society for Microbiology-Meeting, New Orleans, Abstract C 186
Tsai TF, Finn DR, Plikaytis BB (1979) Legionnaires’ disease: clinical features of the epidemic in Philadelphia. Ann Intern Med 90: 509–517
Tseng CH, Renner ED (1983) A new staining method for Legionella pneumophila. Am J Clin Pathol 79: 377–378
Tyndall RL, Domingue EL (1982) Cocultivation of Legionella pneumophila and free-living amoebae. Appl Environ Microbiol 44: 954–959
Tzianabos AO, Rodgers F (1989) Pathogenesis and chemotherapy of experimantal Legionella pneumophila infection in the chick embryo. Zentralbi Bakteriol Mikrobiol Hyg [A] 271: 293–303
Unertl KE, Lenhart FP, Forst H, Vogler G, Wilm V, Ehret W, Ruckdeschel G (1989) Brief report: ciprofloxacin in the treatment of legionellosis in critically ill patients including those cases unresponsive to erythromycin. Am J Med 87: 128S - 131S
Ürlings A, Lütticken R, Höffler U (1986) Vorkommen von Legionellen in Wässern von Klimaanlagen and Naßzellen im Bereich Nordrhein. Off Gesundheitswes 48: 325–328
Van Orden AE, Greer PW (1977) Modification of Dieterle spirochete stain. J Histotechnol 1: 51–53
Vereerstraeten P, Stolear JC, Schoutens-Servuys E et al. (1986) Erythromycin prophylaxis for Legionnaires’ disease in immunosuppressed patients in a contaminated hospital environment. Transplantation 41: 52–54
Vickers RM, Stout JE (1990) Diagnostic monoclonal immunofluorescent reagent fails to detect Legionella pneumophila in environmental samples. American Society for Microbiology-Meeting, New Orleans, Abstract Q 78
Vilde JL, Dournon E, Rajagopalan P (1986) Inhibition of Legionella pneumophila multiplication within human macrophages by antimicrobial agents. Antimicrob Agents Chemother 30: 743–748
Villoslada C, Vilchez IT, Redon J, Pascual JM, Cabello A (1985) Legionnaires’ disease-associated neuropathy. Arch Neurol 42: 733
Viner J, Helms C, Sturm R, Renner E (1978) Legionnaires’ disease among pneumonias with elevated cold agglutinin titers. Clin Res 26:676 A
Voiriot P, Melet M, Aymard JP et al. (1987) Legionnaires’ disease in hairy cell leukemia. 2 new cases. Ann Med Interne (Paris) 138: 287–288
Wadowsky RM, Wolford R, McNamara AM, Yee RB (1985) Effect of temperature, pH, and oxygen level on the multiplication of naturally occurring Legionella pneumophila in potable water. Appl Environ Microbiol 49: 1197–1205
Wegmüller E, Weidmann P, Hess T, Reubi FC (1985) Rapidly progressive glomerulonephritis accompanying Legionnaires’ disease. Arch Intern Med 145: 1711–1713
Weir AD, Bone J, Kennedy DH (1982) Neurological involvement in legionellosis. J Neurol Neurosurg Psychiatry 45: 603–608
Westblom TV, Hamory BH (1988) Acute pancreatitis caused by Legionella pneumophila. South Med J 81: 1200–1201
Widen R, Klein T, Friedman H (1984) Enhanced suscepctibility of cyclophosphamidtreated mice to infection with Legionella pneumophila. J Infect Dis 149: 1023–1024
Wilkinson HW, Brake BJ (1982) Formalin-killed versus heat-killed Legionella pneumophila serogroup 1 antigen in the indirect immunofluorescence assay for legionellosis. J Clin Microbiol 16: 979–981
Wilkinson HW, Fikes BJ, Cruce DD (1979) Indirect immunofluorescence test for serodiagnosis of Legionnaires’ disease: evidence for serogroup diversity of Legionnaires’ disease bacterial antigens and for multiple specificity of human antibodies. J Clin Microbiol 9: 379–383
Wilkinson HW, Reingold AL, Brake BJ, McGiboney DL, Gorman GW, Broome CV (1983) Reactivity of serum from patients with suspected legionellosis against 29 antigens of legionellaceae and Legionella-like organisms by indirect immunofluorescence assay. J Infect Dis 147: 23–31
Wilkinson HW, Thacker WL, Brenner DJ, Ryan KJ (1985) Fatal Legionella maceachernii pneumonia. J Clin Microbiol 22: 1055
Wilkinson HW, Sampson JS, Plikaytis BB (1986) Evaluation of a commercial gene probe for identification of Legionella cultures. J Clin Microbiol 23: 217–220
Wilkinson HW, Thacker WL, Benson RF et al. (1987) Legionella birminghamensis sp. nov. isolated from a cardiac transplant recipient. J Clin Microbiol 25: 2120–2122
Wilkinson IJ, Sangster N, Ratcliff RM, Mugg PA, Davos DE, Lanser JA (1990) Problems associated with identification of Legionella species from the environment and isolation of six possible new species. Appl Environ Microbiol 56: 796–802
Winn WC Jr (1988) Legionnaires’ disease: historical perspective. Clin Microbiol Rev 1: 60–81
Winn WC Jr, Myerowitz RL (1981) The pathology of the Legionella pneumonias: a review of 74 cases and the literature. Hum Pathol 12: 401–422
Winter JH, McCartney C, Bingham J, Telfer M, White LO, Fallon RJ (1988) Ciprofloxacin in the treatment of severe Legionnaires’ disease. Rev Infect Dis 10 [Suppl 1]: 218–219
Wong MC, Ewing EP Jr, Callaway CS, Peacock WL Jr (1980) Intracellular multiplication of Legionella pneumophila in cultured human embryonic lung fibroblasts. Infect Immun 28: 1014–1018
Woo AH, YU VL, Goetz A (1986) Potential in-hospital modes of transmission of Legionella pneumophila. Demonstration experiments for dissemination by showers, humidifiers, and rinsing of ventilation bag apparatus. Am J Med 80: 567–573
Woodhead MA, McFarlane JT (1987) Comparative clinical and laboratory features of legionella with pneumococcal and mycoplasma pneumonias. Br J Dis Chest 81: 133–139
Woodhead MA, McFarlane JT, Macrae AD, Pugh SF (1986) The rise and fall of Legionnaires’ disease in Nottingham. J Infect 13: 293–296
Wreghitt TG, Nagington J, Gray J (1982) An ELISA test for the detection of antibodies to Legionella pneumophila. J Clin Pathol 35: 657–660
Wright JB, Athar MA, Van Olm TM, Wortliff JS, Costerton JW (1989) Atypical legionellosis: isolation of Legionella pneumophila from a patient with aspiration pneumonia. J Hosp Infect 13: 187–190
Wynckel A, Toupance O, Melin JP et al. (1991) Traitement des légionelloses par ofloxacine chez le transplanté rénal. Absence d’interférence avec ciclosporine A. Presse Med 20: 291–293
Yoshida S, Mizuguchi Y (1984) Antibiotic susceptibility of Legionella pneumophila Philadelphia-1 in cultured guinea pig peritoneal macrophages. J Gen Microbiol 130: 901–906
Yu VL, Kroboth FJ, Shonnard J, Brown A, McDearman S, Magnussen M (1982) Legionnaires’ disease: new clinical perspectives from a prospective pneumonia study. Am J Med 73: 357–361
Zazzo JF, Mercat A, Wolff M, Letulzo Y, Regnier B (1988) ARDS associated with nosocomial legionellosis: dramatic effect of indomethacin. Intensive Care Med 14: 679–680
Zhao X, Dreyfus LA (1990) Expression and nucleotide sequence analysis of the Legionella pneumophila recA gene. FEMS Microbiol Lett 70: 227–232
Zimmermann SE, French ML, Allen SD, Wilson E, Kohler RB (1982) Immunoglobulin M antibody titers in the diagnosis of Legionnaires’ disease. J Clin Microbiol 16: 1007–1011
Zuravleff J, Yu VL, Shonnard JW, Rihs JD, Best M (1983) Legionella pneumophila contamination of a hospital humidifier: demonstration of aerosol transmission and subsequent subclinical infection in exposed guinea pigs. Am Rev Respir Dis 128: 657–661
Weiterführende Literatur
Balows A, Fraser DW (1979) International Symposium on Legionnaires’ Disease. Ann Intern Med 90: 491–714
Barbaree JM, Breiman RF, Dufour AP (1993) Legionella.Current Status and Future Trends. American Society for Microbiology, Washington DC
Bartlett CLR, Macrae AD, Macfarlane JT (1986) Legionella infections. Edward Arnold, London
Brundrett GW (1992) Legionella and building services. Butterworth — Heinemann
Exner M (1991) Verhütung, Erkennung und Bekämpfung von Legionelleninfektionen im Krankenhaus. Das Krankenhaus 10: 460–523
Harrison TG, Taylor AG (1988) A Laboratory Manual for Legionella. Wiley & Sons, New York
Johnson JD, Raff MJ, Van Arsdall JA (1984) Neurologic manifestations of Legionnaires’ disease. Medicine (Baltimore) 63: 303–310
Lattimer GL, Ormsbee RA Legionnaires’ disease. Dekker, New York
Müller HE, Dünnleder W, Mühlenberg W, Ruckdeschel G (1992) Legionellen — ein aktuelles Problem der Sanitärhygiene. Expert-Verlag
Sarosi GA (ed) (1987) Legionnaires’ disease. Sem Respir Infect 2:89–284
Thornsberry C, Balows A, Feeley JC, Jakubowski W (1984) Legionella. Proceedings of the 2nd International Symposium. American Society for Microbiology, Washington DC
Weir AD, Bone J, Kennedy DH (1982) Neurological involvement in legionellosis. J Neurol Neurosurg Psychiatry 45: 603–608
Winn WC Jr (1988) Legionnaires’ disease: historical perspective. Clin Microbiol Rev 1: 60–81
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Ruckdeschel, G., Ehret, W. (1993). Die Legionelleninfektion. In: Brandis, M., Fanconi, A., Frick, P., Kochsiek, K., Riecken, E.O. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics, vol 61. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78100-1_4
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