Skip to main content

Bone Marrow Transplantation in the Treatment of Congenital T Cell Disorders

  • Conference paper
Symposium in Immunology I and II
  • 28 Accesses

Abstract

Bone marrow transplantation (BMT) plays a central role in the management of congenital immunodeficiencies characterized by profound abnormalities of the T cell system [10, 14, 19]. This heterogeneous group of disorders may be corrected by the establishment of a new, donor-dependent immmune system. BMT in these disorders also represents a unique model to study and to define cellular interactions which are operative in the functional reconstitution of the lymphohemopoietic system in man.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bortin MM, Rimm RA (1977) Severe combined immunodeficiency: characterization of the disease and results of bone marrow transplantation. JAMA 238: 591–608

    Article  PubMed  CAS  Google Scholar 

  2. Buckley H, Schiff SE, SampsonHA, Schiff RI et al. (1986) Development of immunity in human severe primary T cell deficiencies following haploidentical bone marrow transplantation. J Immunol 136: 2398–2407

    PubMed  CAS  Google Scholar 

  3. Fischer A, Friedrich W, Levinsky R,Vossen J et al. (1986) Bone marrow transplantation for immunodeficiencies and osteopetrosis: European survey 1968–1985. Lancet II: 1080–1083

    Article  Google Scholar 

  4. Fischer A, Landais P, Friedrich W, Morgan G et al. (1990) European experience of bone-marrow transplantation for severe combined immunodeficiency. Lancet II: 850–854

    Article  Google Scholar 

  5. Fischer A, Friedrich W, Fasth A, Blanche S et al. (1991) Reduction of graft failure by a monoclonal antibody (anti-LFA-1 CD11a) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies, osteopetrosis and Fanconi’s anemia: a European Group for Immunodeficiency/European Group for Bone Marrow Transplantation Report. Blood 77: 249–256

    PubMed  CAS  Google Scholar 

  6. Friedrich W, Peter HH, Blütters-Sawatzki R, Ebell W (1986) Analysis of the immunoreconstitution in 19 patients with severe combined immunodeficiency after HLA haploidentical bone-marrow transplantation. In: Vossen J, Griscelli C (eds) Progress in immunodeficiency research and therapy II. Experta Medica, Amsterdam, pp 351–359

    Google Scholar 

  7. Friedrich W, Goldmann SF, Vetter U, Fliedner TM et al. (1984) Immunological reconstitution in severe combined immunodeficiency after transplantation of HLA haploidentical, T cell depleted bone-marrow. Lancet I: 761–764

    Article  Google Scholar 

  8. Friedrich W, Goldmann SF, Ebell W, Blütters-Sawatzki R et al. (1986) Severe combined immunodeficiency: treatment by bone-marrow transplantation in 15 infants using HLA haploidentical donors. Eur J Pediatr 144: 125–130

    Article  Google Scholar 

  9. Gatti RA, Meeuwissen HJ, Allen HD, Hong R, Good R (1968) Immunologic reconstituion of sex linked lymphopenic immunodeficiency. Lancet II: 1366–1369

    Article  Google Scholar 

  10. Good RA, Kapoor N, Pahwa RN Wert A, O’Reilly RJ (1980) Current approaches to the primary immunodeficiencies In: Fougereau M, Dausset J (eds) Progress in immunology IV. Academic, London

    Google Scholar 

  11. Griscelli C, Durandy A, Virelizier JL,Ballet JJ et al. (1978) Selective defect of precursor T cells associated with apparently normal B lymphocytes in severe combined immunodeficiency. J Pediatr 93: 404–411

    Article  PubMed  CAS  Google Scholar 

  12. Kapoor N, Kirkpatrick D, Blaese RM, Oleske J et al. (1981) Reconstitution of normal megakaryocytopoiesis and immune functions in Wiskott-Aldrich syndrome by marrow transplantation following myeloablation and immunosuppression with busulfan and cyclophosphamide. Blood 57: 692–699

    PubMed  CAS  Google Scholar 

  13. Kenny AB, Hitzig WA (1979) Bone marrow transplantation for severe combined immunodeficiency. Eur J Pediatr 131: 155–177

    Article  PubMed  CAS  Google Scholar 

  14. O’Reilly RJ, Brochstein J, Dinsmore B, Kirkpatrick (1984) Marrow transplantation for congenital disorders. Semin Hematol 21: 188–213

    PubMed  Google Scholar 

  15. O’Reilly J, Keever CA, Small TN, Brochstein J (1990) The use of HLA-nonidentical T-cell depleted marrow transplants for correction of severe combined immunodeficiency disease. Immunodefic Rev 1: 273–309

    Google Scholar 

  16. Parkman R, Rappaport D, Geha R, Cassady R et al. (1978) Complete correction of Wiskott-Aldrich syndrome by allogeneic marrow transplantation. N Engl J Med 298: 921–927

    Article  PubMed  CAS  Google Scholar 

  17. Pollak MS, Kirkpatrick D, Kapoor N, O’Reilly (1982) Identification by HLA typing of intrauterine-derived maternal T cells four patients with severe combined immunodeficiency. N Engl J Med 307: 662–666

    Article  Google Scholar 

  18. Reisner Y, Kapoor N, Kirpatrick D, Cunningham-Rundels S et al. (1983) Transplantation for severe combined immunodeficiency with HLA A, B, C, DR incompatible paternal marrow fractionated by soybean agglutination and sheep red blood cells. Blood 61: 341–348

    PubMed  CAS  Google Scholar 

  19. Rosen FS, Cooper MD, Wegewood RJP (1984) The primary immunodeficiencies. N Engl J Med 311: 235–242; 300–310

    Article  PubMed  CAS  Google Scholar 

  20. Rumelhart SL, Trigg ME Horowitz SD, Hong R (1990) Monoclonal antibody T-cell-depleted HLA-haploidentical bone marrow transplantation for Wiskott-Aldrich syndrome. Blood 75: 1031–1035

    PubMed  CAS  Google Scholar 

  21. World Health Organization (1983) Primary immunodeficiency disease (Report prepared for the WHO by a scientific group on immunodeficiencies). Clin Immunol Immunpathol 28: 447–450

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Friedrich, W., Knobloch, C., Hartmann, W. (1993). Bone Marrow Transplantation in the Treatment of Congenital T Cell Disorders. In: Eibl, M.M., Huber, C., Peter, H.H., Wahn, U. (eds) Symposium in Immunology I and II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78087-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78087-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56478-2

  • Online ISBN: 978-3-642-78087-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics