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Induction of Selective Immunosuppression by Administration of MHC Class II Binding Peptides

  • L. Adorini
Conference paper

Abstract

Antigen processing and presentation entail a complex set of events leading to the activation of specific T cells by a binary ligand formed by antigenic peptides bound to major histocompatibility complex (MHC) encoded molecules [1,2]. Over the past few years considerable progress has been made in understanding antigen processing and presentation [3–6]. The essential steps involve intracellular antigen proteolysis in antigen-presenting cells (APC), association of peptides to MHC molecules, and expression on the APC surface of the peptide-MHC complexes. Peptides bound to class I or class II MHC molecules on the surface of APC serve as ligands for the α/β T cell receptors (TCR) of CD8+ or CD4+ cells, respectively.

Keywords

Major Histocompatibility Complex Experimental Autoimmune Encephalomyelitis Major Histocompatibility Complex Class Myelin Basic Protein Binding Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1993

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  • L. Adorini

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