Abstract
Antigen processing and presentation entail a complex set of events leading to the activation of specific T cells by a binary ligand formed by antigenic peptides bound to major histocompatibility complex (MHC) encoded molecules [1,2]. Over the past few years considerable progress has been made in understanding antigen processing and presentation [3–6]. The essential steps involve intracellular antigen proteolysis in antigen-presenting cells (APC), association of peptides to MHC molecules, and expression on the APC surface of the peptide-MHC complexes. Peptides bound to class I or class II MHC molecules on the surface of APC serve as ligands for the α/β T cell receptors (TCR) of CD8+ or CD4+ cells, respectively.
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Adorini, L. (1993). Induction of Selective Immunosuppression by Administration of MHC Class II Binding Peptides. In: Eibl, M.M., Huber, C., Peter, H.H., Wahn, U. (eds) Symposium in Immunology I and II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78087-5_25
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DOI: https://doi.org/10.1007/978-3-642-78087-5_25
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