Induction of Selective Immunosuppression by Administration of MHC Class II Binding Peptides

  • L. Adorini
Conference paper


Antigen processing and presentation entail a complex set of events leading to the activation of specific T cells by a binary ligand formed by antigenic peptides bound to major histocompatibility complex (MHC) encoded molecules [1,2]. Over the past few years considerable progress has been made in understanding antigen processing and presentation [3–6]. The essential steps involve intracellular antigen proteolysis in antigen-presenting cells (APC), association of peptides to MHC molecules, and expression on the APC surface of the peptide-MHC complexes. Peptides bound to class I or class II MHC molecules on the surface of APC serve as ligands for the α/β T cell receptors (TCR) of CD8+ or CD4+ cells, respectively.


Major Histocompatibility Complex Experimental Autoimmune Encephalomyelitis Major Histocompatibility Complex Class Myelin Basic Protein Binding Peptide 
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© Springer-Verlag Berlin Heidelberg 1993

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  • L. Adorini

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