Clinical Trials Sponsored by Companies Versus the NIH
This subject receives less attention in the literature than do the many other topics covered in the Symposium. Instead of buttressing the contents of this article by reference to the medical literature, the authors have decided to offer their own views based on personal experience. This experience includes the following: both have held full-time academic positions, from which they have sought and been funded both by the NIH and various drug companies; one is now a member of a drug company research firm, the other is a consultant to a company; both have participated in clinical trials assessing surgical versus FDA-approved medical therapy, medical therapy between two FDA-approved agents, and medical therapy for agents not yet approved by the FDA for any indications or for the indication for which a given trial has been organized; and, both have participated in trials funded by the NIH alone, drug company alone, or a mixture of the two. Each of these experiences has provided some insights into the similarities and differences between the various forms of sponsored research. Similarities exceed differences, and in recent years similarities are growing.
KeywordsIndirect Cost Acute Stroke Therapy Clear Negative Effect Large Academic Center Patient Care Coordinator
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