Modification of Brain Ischemia Due to Embolic Stroke by Tissue-Type Plasminogen Activator With and Without Heparin in a Rabbit Model

  • L. P. Carter
  • A. N. Guthkelch
  • J. Orozco
  • O. Temeltas
Conference paper

Abstract

This communication presents the results of an assessment of the ability of tissue-type plasminogen activator (t-PA), with and without heparinization, to modify the volume of ischemic brain tissue resulting from the introduction into the anterior cerebral circulation of the rabbit model of an embolus of standard size composed of white thrombus [5].

Keywords

Ischemia Heparin Neurol Ketamine Plasminogen 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Carter LP, Guthkelch AN, Orozco J, Temeltas O (1992) Influence of tissue plasminogen activator and heparin on cerebral ischemia in a rabbit model. Stroke 23:883–888PubMedCrossRefGoogle Scholar
  2. 2.
    Kaplan B, Brint S, Tanabe J, Jacewicz M, Wang X-J, Pulsinelli W (1991) Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 22:1032–1039PubMedCrossRefGoogle Scholar
  3. 3.
    Levine SR, Brott TG (1992) Thrombolytic therapy in cerebrovascular disorder. Prog Cardiovase Dis 34:235–262CrossRefGoogle Scholar
  4. 4.
    Okada Y, Sadoshima S, Nakane H, Utsunomiya H, Fujishima M (1992) Early computed tomographic findings for thrombolytic therapy in patients with acute brain embolism. Stroke 23:20–23PubMedCrossRefGoogle Scholar
  5. 5.
    Rigamonte D, Uede T, Johnson PC, et al (1989) A new model of cerebral embolic ischemia using autologous arterial thrombus. Barrow Neurol Inst Q 5(4):2–7Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • L. P. Carter
    • 1
  • A. N. Guthkelch
    • 1
  • J. Orozco
    • 1
  • O. Temeltas
    • 1
  1. 1.Department of Surgery (Section of Neurosurgery)University of Arizona Health Sciences CenterTucsonUSA

Personalised recommendations