A Demming Approach to Recruiting: The National Institute of Neurological Diseases and Stroke (NINDS) t-PA Stroke Trial Experience

  • B. C. Tilley
Conference paper

Abstract

The NINDS t-PA Stroke Trials are two Phase IIB, randomized, double-blind trials comparing recombinant tissue plasminogen activator (t-PA) to placebo. The trials are being carried out by 8 clinical centers and 40 participating hospitals. The primary alternative hypotheses for each trial are that:
  1. 1.

    There is a difference between the t-PA and placebo groups enrolled within 90 min of onset in the proportion showing significant early improvement; and

     
  2. 2.

    There is a difference between the t-PA and placebo groups enrolled between 91 and 180 min of stroke onset in the proportion showing significant early improvement.

     

Keywords

Placebo Heparin Plasminogen Prothrombin Carol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • B. C. Tilley

There are no affiliations available

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