Advertisement

A Demming Approach to Recruiting: The National Institute of Neurological Diseases and Stroke (NINDS) t-PA Stroke Trial Experience

  • B. C. Tilley

Abstract

The NINDS t-PA Stroke Trials are two Phase IIB, randomized, double-blind trials comparing recombinant tissue plasminogen activator (t-PA) to placebo. The trials are being carried out by 8 clinical centers and 40 participating hospitals. The primary alternative hypotheses for each trial are that:
  1. 1.

    There is a difference between the t-PA and placebo groups enrolled within 90 min of onset in the proportion showing significant early improvement; and

     
  2. 2.

    There is a difference between the t-PA and placebo groups enrolled between 91 and 180 min of stroke onset in the proportion showing significant early improvement.

     

Keywords

Emergency Department Stroke Onset Oral Anticoagulant Therapy Stroke Trial Recombinant Tissue Plasminogen Activator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • B. C. Tilley

There are no affiliations available

Personalised recommendations