Abstract
The very title of this section of the symposium, i.e., “Ancillary Therapy for Cerebrovascular Reperfusion,” underscores the prominent hopes and expectations that the stroke community has invested in thrombolytic therapy. Thrombolysis makes intuitive sense, is effective in other circulatory beds, and may result in dramatic clinical changes. Furthermore, it requires mobilization of emergency personnel which requires neurologists to depart from their traditional passive therapeutic attitude towards stroke.
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References
American Nimodipine Study Group (1992) Clinical trial of nimodipine in acute stroke. Stroke 23:3–8
DeGraba T, Grotta J (1991) Ca++ influx an a predictor of neuronal damage after graded global ischemia. Stroke 22:140
DeGraba T, Hanson S, Ostrow P, Grotta J (1992) Calcium influx, histologic damage, and motor performance in rats treated with NBQX after focal ischemia. Neurology 42(Suppl III):361
Gotoh O, Mohammed A, McCullough J, Graham D, Harper A, Teasdale G (1986) Nimodipine and the hemodynamic and histopathologic consequences of middle cerebral artery occlusion in the rat.. J Cereb Blood Flow Metab 6:321–331
Grotta J, DeGraba T (1992) How fast must we start neuroprotective therapies after cerebral ischemia? Stroke 23:147
Grotta J, Pettigrew L, Reid C, Rosenbaum D, McCandless D, Rhoades H (1988) Studies on the efficacy and mechanism of action of a calcium blocker after global cerebral ischemia. Stroke 19:447–454
Grotta J, Picone C, Dedman J, et al (1990) Neuronal protection correlates with prevention of calcium-caimodulin binding. Stroke 21(Suppl III):28–31
Grotta J, Picone C, Earls R, Strong R, Yao L, Dedman J (1990) Calcium-calmodulin binding in ischemic rat neurons after calcium channel blocker therapy. Stroke 21:948–952
Grotta J, Picone C, Ostrow P, et al (1990) CGS 19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann Neurol 27:612–619
Hewitt K, Corbett D (1992) Combined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil. Stroke 23:82–86
International Nimodipine Study Group (1992) Meta-analysis of nimodipine trials in acute ischemic stroke. Stroke 23:148
Jacewicz M, Brint S, Tanabe J, Pulsinelli A (1990) Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia. J Cereb Blood Flow Metab 10:89–96
Olney J, Labruyere J, Price M (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360
Park C, Nehls D, Graham D (1988) Focal cerebral ischemia in the cat: Treatment with the glutamate antagonist MK-801 after induction of ischemia. J Cereb Blood Flow Metab 8:757
Picone C, Grotta J, Earls R, Strong R, Dedman J (1989) Immunohistochemical determination of calcium-calmodulin binding predicts neuronal damage after global ischemia. J Cereb Blood Flow Metab 9:805–811
Pulsinelli W, Brierley J, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491–498
Rosenbaum D, Zabramski J, Frey J, et al (1991) Early treatment of ischemic stroke with a calcium antagonist. Stroke 22:437–441
Sharp F, Jasper P, Butman M (1992) Haloperidol prevents induction of HSP72 heat shock protein in posterior cingulate neurons injured by MK801, ketamine, and PCP: Implications for stroke therapy and psychosis. Neurology 42(Suppl III):360
Sheardown M, Nielsen E, Hansen A, Jacobsen P, Honore T (1990) 2, 3-dihydroxy-6-nitro-7-sylfamoyl-benzo (F) quinoxaline: A neuroprotectant for cerebral ischemia. Science 247:571–574
Steinberg G, Bell T (1991) Clinical dose-escalation safety study of the NMDA antagonist, dextromethorphan in neurosurgical patients. Stroke 22:141
Uematsu D, Araki N, Greenberg JH, Sladky J, Reivich M (1991) Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage. Neurology 41:88–94
Zivin J, Mazzarella V (1991) Tissue plasminogen activator plus glutamate antagonist improves outcome after embolic stroke. Arch Neurol 48:1235–1238
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© 1993 Springer-Verlag Berlin Heidelberg
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Grotta, J. (1993). Neuronal Protection and Recanalization Strategies: Is More Better?. In: del Zoppo, G.J., Mori, E., Hacke, W. (eds) Thrombolytic Therapy in Acute Ischemic Stroke II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78061-5_33
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DOI: https://doi.org/10.1007/978-3-642-78061-5_33
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