Skip to main content

Thrombolytic and Antithrombotic Therapy in Acute Ischemic Stroke. Multicenter Acute Stroke Trial — Italy (MAST-I)

  • Conference paper
Thrombolytic Therapy in Acute Ischemic Stroke II

Abstract

Stroke is a major cause of death and disability, and it consumes a large proportion of health resources. Numerous treatments have been suggested for acute ischemic stroke but so far none has been shown to be effective in large randomized controlled trials. Thrombolytic treatment, which is so effective in acute myocardial infarction, has been evaluated in numerous individual stroke patients and some small pilot studies. Its efficacy now needs to be tested in a large multicenter trial.

Presented by L. Candelise, Istituto di Clinica Neurologica, Università degli Studi di Milano, Milano, Italy

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico: GISSI-2 (1990) A factorial randomized trial of alteplase versus streptokinase and heparin versus no heparin among 12, 490 patients with acute myocardial infaction. Lancet 336:65–70

    Google Scholar 

  2. Antiplatelet Trialist’s Collaboration (1988) Secondary prevention of vascular disease by prolonged antiplatelet treatment. Br Med J 296:320–331

    Article  Google Scholar 

  3. Brott T, Haley C, Levy D, et al (1990) Safety and potentional efficacy of tissue plasminogen activator (tPA) for stroke (Abstract). Stroke 2:181

    Google Scholar 

  4. Candelise L, Pinardi G, Aritzu E (1990) Stroke disability assessed by telephone interview: Reliability and reproducibility (Abstract). J Neurol 237:143

    Google Scholar 

  5. del Zoppo GJ (1988) Thrombolytic therapy in cerebrovascular disease. Stroke 19:1174–1179

    Article  PubMed  Google Scholar 

  6. del Zoppo GJ, Poeck K, Pessin MS, and 16 coauthors of the rt-PA Acute Stroke Study Group (1992) Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 32:78–86

    Article  PubMed  Google Scholar 

  7. ISIS-2 (Second International Study of Infarct Survival Collaborative Group) (1988) Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17, 187 cases of suspected acute myocardial infarction. Lancet 13:349–360

    Google Scholar 

  8. ISIS-3 (Third International Study of Infarct Survival Collaborative Group) (1992) A randomized comparison of streptokinase vs. tissue plasminogen activator vs. anistreplase and of aspirin plus heparin vs. aspirin among 41, 299 cases of suspected acute myocardial infarction. Lancet 339:753–770

    Article  Google Scholar 

  9. Italian Acute Stroke Study Group (L.Candelise principal investigator) (1988) Haemodilution in acute stroke: Results of the Italian haemodilution trial. Lancet 1:318–321

    Google Scholar 

  10. Sloan MA (1987) Thrombolysis and stroke: Past and future. Arch Neurol 44:748–768

    Article  PubMed  CAS  Google Scholar 

  11. Sundt T, Sharbrough F, Anderson R, Michenfelder J (1974) Cerebral blood flow measurements and electroencephalograms during carotid endarterectomy. J Neurosurg 41:310–320

    Article  PubMed  Google Scholar 

  12. The International Study Group (1990) In-hospital mortality and clinical course of 20, 891 patients with suspected acute myocardial infarction randomized between alteplase and streptokinase with or without heparin. Lancet 336:71–75

    Article  Google Scholar 

  13. von Kummer R, Hutschenreuter M, Wildemann B, Hacke W (1989) Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in acute occlusions of intracranial arteries. J Cereb Blood Flow Metab 9(Suppl):5721

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

del Zoppo, G.J., Mori, E., Hacke, W. (1993). Thrombolytic and Antithrombotic Therapy in Acute Ischemic Stroke. Multicenter Acute Stroke Trial — Italy (MAST-I). In: del Zoppo, G.J., Mori, E., Hacke, W. (eds) Thrombolytic Therapy in Acute Ischemic Stroke II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78061-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78061-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56442-3

  • Online ISBN: 978-3-642-78061-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics