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Australian Streptokinase Trial (ASK)

  • G. A. Donnan
  • S. M. Davis
  • B. R. Chambers
  • P. C. Gates
  • G. J. Hankey
  • E. G. Stewart-Wynne
  • D. Rosen
  • R. R. Tuck
  • J. J. McNeil

Abstract

A multicenter randomized controlled trial will be conducted to test the hypothesis that the intravenous administration of the thrombolytic agent streptokinase within 4 h of the onset of acute ischemic stroke will result in a significant reduction in subsequent morbidity and mortality. Six hundred eligible patients from 20 to 30 centers will be randomized to receive either 1.5 × 106 units of streptokinase or placebo infused over 60 min. Patients will be accrued over a 3-year period and the results analyzed on an intention-to-treat basis. Primary end-points will be death and 3-month disability on Barthel index or, if no significant difference in death rates between treatment and placebo groups exists, the primary end-point will be improvement in Modified Canadian Neurological Score (MCNS) among the living.

Keywords

Acute Ischemic Stroke Steering Committee Barthel Index Proliferative Diabetic Retinopathy Hemorrhagic Transformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • G. A. Donnan
    • 1
  • S. M. Davis
    • 2
  • B. R. Chambers
    • 3
  • P. C. Gates
    • 4
  • G. J. Hankey
    • 5
  • E. G. Stewart-Wynne
    • 5
  • D. Rosen
    • 6
  • R. R. Tuck
    • 6
  • J. J. McNeil
    • 7
  1. 1.Department of NeurologyAustinUSA
  2. 2.Department of NeurologyRoyal Melbourne HospitalMelbourneAustralia
  3. 3.Department of NeurologyRepatriation General HospitalMelbourneAustralia
  4. 4.Geelong HospitalGeelongAustralia
  5. 5.Royal Perth HospitalPerthWestern Australia
  6. 6.Royal Prince Alfred HospitalSydneyAustralia
  7. 7.Department of Social and Preventive MedicineMonash UniversityAustralia

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