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Ovarian Carcinoma: Tumor- and Molecular Biology

  • Chapter
Das Ovarialkarzinom

Abstract

During the normal monthly ovulatory cycle, ovarian surface epithelium undergoes a set of changes including destruction, proliferation, and regeneration which is regulated by many (peptide and steroid) hormones and their receptors. The corresponding genes transduce receptor/ligand signals to alter DNA synthesis and gene expression. Point mutation, rearrangement, or deletions of chromosomal DNA sequences which alter the function and/or expression of these genes might sufficiently perturb normal ovarian epithelial cell proliferation and differentiation to produce benign, borderline, and invasively-ma- lignant neoplasms from normal surface epithelium.

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Authors
  1. B. Kacinski
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Editors and Affiliations

  1. Universitäts-Frauenklinik, Hugstetter Straße 55, W-7800, Freiburg, Deutschland

    Hans-Gerhard Meerpohl  & Albrecht Pfleiderer  & 

  2. Farmitalia Carlo Erba GmbH, Merzhauser Straße 112, W-7800, Freiburg, Deutschland

    Christian Z. Profous

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© 1993 Springer-Verlag Berlin Heidelberg

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Kacinski, B. (1993). Ovarian Carcinoma: Tumor- and Molecular Biology. In: Meerpohl, HG., Pfleiderer, A., Profous, C.Z. (eds) Das Ovarialkarzinom. AGO Arbeitsgemeinschaft für Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78041-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-78041-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56405-8

  • Online ISBN: 978-3-642-78041-7

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