Skip to main content

Screening for Ovarian Cancer

  • Chapter
Das Ovarialkarzinom
  • 16 Accesses

Abstract

As a profession we devote a huge amount of time and money to the early detection and investigation of cervical and endometrial carcinoma. If one considers the fact that more women die each year from ovarian cancer than from cancer of the uterus and cervix combined, the failure to investigate methods to detect ovarian cancer at an early stage is puzzling. The relative lack of information regarding the natural history of ovarian cancer has hindered workers in this field. The result is that the vital question of whether screening for and thus early detection and treatment of ovarian cancer actually reduces mortality from the disease has yet to be answered. A randomised controlled clinical trial is needed to test this hypothesis. We believe that an ultrasound based screening test now exists with sufficient sensitivity and specificity to be utilised in the context of such a clinical trial. This article will set out the arguments for this proposal.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Office of Population Censuses and Surveys: Cancer statistics: registrations, England and Wales 1984, HMSO. London, 1988

    Google Scholar 

  2. Day T.G., Smith J.P.: Diagnosis and staging of ovarian cancer. Semin. Oncol. 2: 217,1975

    PubMed  Google Scholar 

  3. Young R.C., Walton L.A., Ellenberg S.S., Homesley H.D., Wilbanks G.D., Decker D.G., Miller A., Park R., Major F. Jr.: Adjuvant therapy in stage I and stage II epithelial ovarian cancers - results of two prospective randomised trials. N. Eng. J. Med. 322: 1021–1027,1990

    Article  CAS  Google Scholar 

  4. Annual report on cancer statistics

    Google Scholar 

  5. Bourne T.H., Reynolds K., Campbell S.: Ovarian Cancer Screening. Eur. J. Cancer 27: 655–659,1991

    Article  PubMed  CAS  Google Scholar 

  6. Wilson J.M.G., Jungner G.: In: Principles and Practice of Screening for Disease. Public Health Papers 34, World Health Organisation, Geneva, 1968

    Google Scholar 

  7. Cuckle H.S., Wald N.J., In Sharp F., Mason W., Leake R.E., eds.: Ovarian Cancer: Biological and Therapeutic Challenges. Cambridge, Chapman and Hall Medical, 229–239,1990

    Google Scholar 

  8. Daunter B.: Tumor markers in gynecologic oncology. Gynecol. Oncol. 39: 1–15,1990

    Article  PubMed  CAS  Google Scholar 

  9. Jacobs I., Bast R.C.: The CA 125 tumour associated antigen: a review of the literature. Human Reproduction 4: 1–12,1989

    PubMed  CAS  Google Scholar 

  10. Zurawski V.R., Orjaseter H., Anderson A., Jellum E.: Elevated serum CA 125 levels prior to the diagnosis of ovarian neoplasia: relevance for early detection of ovarian cancer. Int J. Cancer 42: 677–680,1988

    Article  PubMed  Google Scholar 

  11. Jacobs I.J., Stabile I., Bridges J., Kemsley P., Reynolds C., Grudzinskas J.G., Oram D.H.: Multimodal approach to screening for ovarian cancer. Lancet, i: 268–271,1988

    Google Scholar 

  12. Zurawski V.R., Sjovall K., Schoenfeld D.A., Broderick S.F., Hall P., Bast R.C., Eklund G., Mattsson B., Connor R.J., Prorok P.C., Knapp R.C., Einhorn N.: Prospective evaluation of CA 125 levels in normal population, phase I: The specificities of single and serial determinations in testing for ovarian cancer. Gynecol. Oncol. 36: 299–305, 1990

    Article  PubMed  Google Scholar 

  13. Campbell S., Goessons L., Goswamy R., Whitehead M.I.: Real time ultrasonography for determination of ovarian morphology and volume - a possible new screening test for ovarian cancer ? Lancet, i: 425–426, 1982

    Google Scholar 

  14. Campbell S., Bhan V., Royston P., Whitehead M.I., Collins W.P.:. Transabdominal ultrasound screening for early ovarian cancer. British. Medical Journal, 299: 1363–1367,1989

    Article  PubMed  CAS  Google Scholar 

  15. Campbell S., Bhan V., Royston P., Whitehead M.I., Collins W.P.: Novel screening strategies for early ovarian cancer by transabdominal ultrasonography. Br. J. Obstet. Gynaecol. 97: 304–311, 1990

    Article  PubMed  CAS  Google Scholar 

  16. Luxman D., Bergman A., Sagi J., David M.P.: The Postmenopausal Adnexal Mass: Correlation Between Ultrasonic and Pathologic Findings. Obstet. Gynecol. 77: 726–728, 1991

    PubMed  CAS  Google Scholar 

  17. Parker W.H., Berek J.S.: Management of selected cystic adnexal masses in postmenopausal women by operative laparoscopy: a pilot study. Am. J. Obstet. Gynecol. 163: 1574–1577, 1990

    PubMed  CAS  Google Scholar 

  18. Timor-Trisch I.E., Bar-Yam Y., Elgali S., Rottem S.: The technique of transvaginal sonography with the use of a 6.5 Mhz probe. Am. J. Obstet. Gynecol. 158: 1019–1024, 1988

    Google Scholar 

  19. Bourne T.H.: Transvaginal color Doppler in Gynecology. Ultrasound Obstets Gynecol.l: 359–373,1991

    Article  Google Scholar 

  20. Rodriguez M.H., Platt L.D., Medearis A.L., Lacarra M., Lobo R.A.: The use of transvaginal sonography for evaluation of postmenopausal ovarian size and morphology. Am. J. Obstet. Gynecol. 159: 810–814, 1988

    PubMed  CAS  Google Scholar 

  21. Van Nagell J.R., Higgins R.V., Donaldson E.S., Gallion H.H., Powell D.E., Pavlik E.J., Woods C.H.: Transvaginal sonography as a screening test for ovarian cancer. A report of the first 1000 cases screened. Cancer 65: 573–577,1990

    Article  PubMed  Google Scholar 

  22. Bourne T.H., Whitehead M.I., Campbell S., Royston P., Bhan V., Collins W.P.: Ultrasound screening for familial ovarian cancer. Gynecologic Oncology, 43: 92–97, 1991

    Article  PubMed  CAS  Google Scholar 

  23. Lynch H.T., Watson P., Bewtra C., Conway T.A., Hippee C.R., Kaur P., Lynch J.F., Ponder B.A.J.: Hereditary ovarian cancer. Cancer 67: 1460–1466, 1991

    Article  PubMed  CAS  Google Scholar 

  24. Meire H.B., Farrant P., Guha T.: Distinction of benign from malignant ovarian cysts by ultrasound. Br. J. Obstet. Gynaecol. 85: 893–899, 1978

    Article  PubMed  CAS  Google Scholar 

  25. Sassone A.M., Timor-Tritsch I.E., Artner A., Westhoff C., Warren W.B.: Transvaginal sonographic characterisation of ovarian disease: evaluation of a new scoring system to predict malignancy. Obstet. Gynecol. 78: 70–76, 1991

    PubMed  CAS  Google Scholar 

  26. Folkman J., Watson J., Ingber D., Hanahan D.: Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (London), 339: 58–61,1989

    Article  PubMed  CAS  Google Scholar 

  27. Bourne T.H., Campbell S., Steer C.V., Whitehead M.I., Collins W.P.: Transvaginal colour flow imaging: a possible new screening test for ovarian cancer. British Medical Journal, 229: 1367–1370, 1989

    Article  Google Scholar 

  28. Kurjak A., Zalud I.: Early detection of ovarian cancer by transvaginal color Doppler.J. Ultrasound Med. 10: 57, 1991

    Google Scholar 

  29. Bourne T.H., Jurkovic D., Waterstone J., Campbell S., Collins W.P.: Intrafollicular blood flow during human ovulation. Ultrasound Obstet. Gynecol. 1: 63–69,1991

    Google Scholar 

  30. Campbell S., Bourne T.H., Reynolds K., Hampson J., Royston P., Whitehead M.I., Collins W.P.: Role of colour Doppler in and ultrasound based screening programme. In Sharp F., Mason W.P., Leake R.E. (Eds) Ovarian Cancer Biological and Therapeutic Challenges, Vol II (Cambridge: Chapman and Hall Medical)

    Google Scholar 

  31. Bourne T.H., Campbell S., Royston P., Whitehead M.I., Steer C.V., Collins W.P.: Detection of Endometrial Cancer by Transvaginal Ultrasonography with Color Row Imaging and Blood Row Analysis: A Preliminary Report. Gynecologic Oncology 40: 253–259, 1991

    Article  PubMed  CAS  Google Scholar 

  32. Granberg S.: Bladder tumors, Ultrasound Obstet. Gynecol. 1:1991

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Campbell, S., Bourne, T. (1993). Screening for Ovarian Cancer. In: Meerpohl, HG., Pfleiderer, A., Profous, C.Z. (eds) Das Ovarialkarzinom. AGO Arbeitsgemeinschaft für Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78041-7_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78041-7_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56405-8

  • Online ISBN: 978-3-642-78041-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics