Ontogenetic Development of the Subcommissural Organ with Reference to the Flexural Organ

  • K. Schoebitz
  • E. M. Rodríguez
  • O. Garrido
  • M. A. Del Brió-Leon


The ontogeny of the chick and rat subcommisural organ (SCQ) has been the subject of several reports. Some of these studies were performed on the rat SCO (Kohl and Linderer 1973; Marcinkiewicz and Bouchaud 1983, 1986; Rakic and Sidman 1968; Naumann et al. 1987; Castañeyra-Perdomo et al. 1983). The SCO of chicken embryos represents the nonmammalian organ model whose ontogenetic development has been most thoroughly investigated (Wingstrand 1953; Ziegels 1977; Schoebitz et al. 1986; Bruel et al. 1987; Naumann et al. 1987; Karoumi et al. 1990). Using classical stains for neurosecretion, Wingstrand (1953) and Ziegels (1977) have reported that the secretory material of the SCO first appears in 7-day-old chick embryos.


Chick Embryo Secretory Granule Ependymal Cell Central Canal Apical Cytoplasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bruel MY, Meiniel A, David D (1987) Ontogenetical study of the chick embryo subcommissural organ by lectin-histofiuorescence and electron microscopy. J Neural Transm 70: 145–178PubMedCrossRefGoogle Scholar
  2. Castaneyra-Perdomo A, Meyer G, Ferres-Torres R (1983) Development of the subcommissural organ in the albino mouse. J Hirnforsch 24: 368–370Google Scholar
  3. Gabe M (1968) Techniques histologiques. Masson, ParisGoogle Scholar
  4. Herrera H, Rodríguez EM (1990) Secretory glycoproteins of the rat subcommissural organ are N-linked complex-type glycoproteins. Demonstration by combined use of lectins and specific glycosidases, and by the administration of Tunicamycin. Histochemistry 93: 607–615PubMedCrossRefGoogle Scholar
  5. Karoumi A, Meiniel R, Croisille Y, Belin MF, Meiniel A (1990) Glycoprotein synthesis in the subcommissural organ of the chick embryo. I. An ontogenical study using specific antibodies. J Neural Transm (Gen Sect) 79: 141–153CrossRefGoogle Scholar
  6. Kohl W, Linderer T (1973) Zur Entwicklung des Subcommissuralorgans der Ratte. Morphologische und histochemische Untersuchungen. Histochemie 33: 349–368PubMedCrossRefGoogle Scholar
  7. Marcinkiewicz M, Bouchaud C (1983) The ependymal secretion of the fetal and adult rat subcommissural organ. Morphological aspects linked to the synthesis, storage and release of the secretory products. Biol Cell 48: 47–52PubMedGoogle Scholar
  8. Marcinkiewicz M, Bouchaud C (1986) Formation and maturation of axoglandular synapses and concomitant changes in the target cells of the rat subcommissural organ. Biol Cell 56: 57–65PubMedGoogle Scholar
  9. Matsuura T, Kumamoto K, Ebara S, Sano Y (1989) Serotonergic innervation of the mammalian subcommissural organ: an immunohistochemical study. Biomed Res 10 [Suppl 3]: 177–186Google Scholar
  10. Naumann W, Miiller G, Kloss P (1987) Immunoreactive glycoprotein of the subcommissural organ in the embryonic stages of the vertebrate brain. Wiss Z Karl Marx Univ Leipzig Math Naturwiss R 36: 17–20Google Scholar
  11. Olsson R (1956) The development of Reissner’s fibre in the brain of the salmon. Acta Zool (Stockh) 37: 235–250CrossRefGoogle Scholar
  12. Rakic P, Sidman RL (1968) Subcommissural organ and adjacent ependyma: autoradiographic study of their origin in the mouse brain. Am J Anat 122: 317–336PubMedCrossRefGoogle Scholar
  13. Rodríguez EM, Oksche A, Hein S, Rodríguez S, Yulis R (1984) Comparative immunocytochemical study of the subcommissural organ. Cell Tissue Res 237: 427–441PubMedGoogle Scholar
  14. Rodríguez EM, Herrera A, Peruzzo B, Rodríguez S, Hein S, Oksche A (1986) Light- and electron-microscopic lectin histochemistry and immunohistochemistry of the subcommissural organ: evidence for processing of the secretory material. Cell Tissue Res 243: 545–559PubMedCrossRefGoogle Scholar
  15. Schoebitz K, Garrido O, Heinrichs M, Speer L, Rodríguez EM (1986) Ontogenetical development of the chick and duck subcommissural organ and immunocytochemical study. Histochemistry 84: 31–40PubMedCrossRefGoogle Scholar
  16. Sterba G, Kiessig C, Naumann W, Petter H, Klein I (1982) The secretion of the subcommissural organ. A comparative immunocytochemical investigation. Cell Tissue Res 226: 427–439PubMedCrossRefGoogle Scholar
  17. Sternberger LA, Hardy PH Jr, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry; preparation of properties of soluble antigen-antibody complex (horseradish peroxidase-antiperoxidase) and its use in identification of spirochetes. J Histochem Cytochem 18: 315–333PubMedCrossRefGoogle Scholar
  18. Wiklund L (1974) Development of serotonin–containing cells and the sympathetic innervation of the habenular region in the rat brain. A fluorescence histochemical study. Cell Tissue Res 155: 231–243PubMedCrossRefGoogle Scholar
  19. Wiklund L, Lundberg JJ, Møllgárd K (1977) Species differences in serotonergic innervation and secretory activity of rat, gerbil, mouse and rabbit subcommissural organ. Acta Physiol Scand [Suppl] 452: 27–30Google Scholar
  20. Wingstrand KG (1953) Neurosecretion and antidiuretic activity in chick embryos with remarks on the subcommissural organ. Arch Zool (Stockh) 6: 41–67Google Scholar
  21. Ziegels J (1977) Etude histochimique de l’organe sous-commissural du poulet au cours du development. CR Soc Biol 171: 1306–1308Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Schoebitz
  • E. M. Rodríguez
  • O. Garrido
  • M. A. Del Brió-Leon

There are no affiliations available

Personalised recommendations