Advertisement

Activity of Ornithine Decarboxylase and Ki-67 Index in Meningiomas

  • R. I. Ernestus
  • R. Schröder
  • G. Röhn
  • N. Klug
  • K. A. Hossmann
  • W. Paschen
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 21)

Abstract

Meningiomas usually are slowly growing brain tumors histologically classified as grade 1 according to the criteria of the World Health Organization (WHO) [26]. Nevertheless, some meningiomas tend to proliferate more rapidly, resulting in an increased incidence of local recurrences up to malignant meningiomatosis.

Keywords

Ornithine Decarboxylase Polyamine Metabolism Benign Meningioma Recurrent Meningioma Grow Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bachrach U (1976) Polyamines as chemical markers of malignancy. Ital J Biochem 25:77–93PubMedGoogle Scholar
  2. 2.
    Böker DK, Stark HJ (1988) The proliferation rate of intracranial tumors as defined by the monoclonal antibody KI 67. Application of the method to paraffin embedded specimens. Neurosurg Rev 11:267–272PubMedCrossRefGoogle Scholar
  3. 3.
    Burger PC, Shibata T, Kleihues P (1986) The use of the monoclonal antibody Ki-67 in the identification of proliferating cells: application to surgical neuropathology. Am J Surg Pathol 10:611–617PubMedCrossRefGoogle Scholar
  4. 4.
    Deckert M, Reifenberger G, Wechsler W (1989) Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67. J Cancer Res Clin Oncol 115:179–188PubMedCrossRefGoogle Scholar
  5. 5.
    Ermestus RI, Röhn G, Paschen W (1991) Polyamine metabolism in experimental brain tumors of rat. J Cereb Blood Flow Metab 11Suppl 2:548Google Scholar
  6. 6.
    Emestus RI, Röhn G, Schröder R, Klug N, Hossmann KA, Paschen W (1992) Activity of ornithine decarboxylase (ODC) and polyamine levels as biochemical markers of malignacy in brain tumors. Acta Histochem Suppl (Jena) 42:159–164Google Scholar
  7. 7.
    Gerdes J, Schwab U,. Lemke H, Stein H (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31:13–20PubMedCrossRefGoogle Scholar
  8. 8.
    Gerdes J, Lemke H, Baisch H, Wacker H, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 31:1710–1715Google Scholar
  9. 9.
    Giangasparo F, Doglioni C, Rivano MT, Pileri S, Gerdes J, Stein H (1987) Growth fraction in human brain tumors defined by the monoclonal antibody Ki-67. Acta Neuropathol (Berl) 74:179–182CrossRefGoogle Scholar
  10. 10.
    Horn Y, Beal SL, Walach N, Lubich WP, Spigel L, Marton LJ (1982) Further evidence for the use of polyamines as biochemical markers for malignant tumors. Cancer Res 42:3248–3251PubMedGoogle Scholar
  11. 11.
    Iwaki T, Takeshita I, Fukui M, Kitamaura K (1987) Cell kinetics of the malignant evolution of meningoendothelial meningioma. Acta Neuropathol (Berl) 74:243–247CrossRefGoogle Scholar
  12. 12.
    Jänne J, Pösö H, Raina A (1978) Polyamines in rapid growth and cancer. Biochim Biophys Acta 473:241–293PubMedGoogle Scholar
  13. 13.
    Louis DN, Edgerton S, Thor AD, Hedley-Whyte ET (1991) Proliferating cell nuclear antigen and Ki-67 immunohistochemistry in brain tumors: a comparative study. Acta Neuropathol (Berl) 81:675–679CrossRefGoogle Scholar
  14. 14.
    Morimura T, Kitz K, Stein H, Budka H (1991) Determination of proliferative activities in human brain tumor specimens: a comparison of three methods. J Neurooncol 10:1–11PubMedCrossRefGoogle Scholar
  15. 15.
    Ostertag CB, Volk B, Shibata T, Burger P, Kleihues P (1987) The monoclonal antibody Ki-67 as a marker for proliferating cells in stereotactic biopsis of brain tumours. Acta Neurochir (Wien) 89:117–121CrossRefGoogle Scholar
  16. 16.
    Paschen W, Röhn G, Meese CO, Djuricic B, Schmidt-Kastner R (1988) Polyamine metabolism in reversible cerebral ischemia. Effect of α-difluoromethylomithine. Brain Res 453:9–16PubMedCrossRefGoogle Scholar
  17. 17.
    Patsouris E, Stocker U, Kallmeyer V, Keiditsch E, Mehraein P, Stavrou D (1988) Relationship between Ki-67 positive cells, growth rate and histological type of human intracranial tumors. Anticancer Res 8:537–544PubMedGoogle Scholar
  18. 18.
    Plate KH, Rüschoff J, Behnke J, Mennel HD (1990) Proliferative potential of human brain tumours as assessed by nucleolar organizer regions (AgNORs) and Ki-67-immunoreactivity. Acta Neurochir (Wien) 104:103–109CrossRefGoogle Scholar
  19. 19.
    Roggendorf W, Schuster T, Pfeiffer J (1987) Proliferative potential of meningiomas determined with the monoclonal antibody Ki-67. Acta Neuropathol (Berl) 73:361–364CrossRefGoogle Scholar
  20. 20.
    Russell DH, Haddox MK (1978) Cyclic AMP-mediated induction of ornithine decarboxylase in normal and neoplastic growth. Adv Enzyme Regul 17:61–79PubMedCrossRefGoogle Scholar
  21. 21.
    Scalabrino G, Ferioli ME (1985) Degree of enhancement of polyamine biosynthetic decarboxylase activities in human tumors: a useful new index of degree of malignancy. Cancer Detect Prev 8:11–16PubMedGoogle Scholar
  22. 22.
    Schröder R, Bien K, Kott R, Meyer I, Vössing R (1991) The relationship between Ki-67 labelling and mitotic index in gliomas and meningiomas: demonstration of the variability of the intermitotic cycle time. Acta Neuropathol (Berl) 82:389–394CrossRefGoogle Scholar
  23. 23.
    Shibata T, Burger PC, Kleihues P (1988) Ki-67 immunoperoxidase stain as a marker for the histological grading of nervous system tumours. Acta Neurochir Suppl (Wien) 43:103–106Google Scholar
  24. 24.
    Shibata T, Ostertag CB, Volk B (1989) Ki-67 PAP stain for histologic grading of brain tumors by squash preparations. No To Shinkei 41:55–60PubMedGoogle Scholar
  25. 25.
    Shiraishi T (1990) Cell kinetic analysis of brain tumors using the monoclonal antibody Ki-67: in vitro and in situ study. Acta Med Okayama 43:187–201Google Scholar
  26. 26.
    Zülch KJ (1986) Brain tumors. Their biology and pathology. 3rd edn. Springer, Berlin Heidelberg New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • R. I. Ernestus
    • 1
    • 2
  • R. Schröder
    • 3
  • G. Röhn
    • 1
  • N. Klug
    • 2
  • K. A. Hossmann
    • 1
  • W. Paschen
    • 1
  1. 1.Abteilung für Experimentelle NeurologieMax-Planck-Institut für Neurologische ForschungKöln 41Germany
  2. 2.Klinik für Neurochirurgie der Universität KölnKöln 41Germany
  3. 3.Institut für Pathologie, Labor für NeuropathologieUniversität KölnKöln 41Germany

Personalised recommendations