Abstract
Meningiomas usually are slowly growing brain tumors histologically classified as grade 1 according to the criteria of the World Health Organization (WHO) [26]. Nevertheless, some meningiomas tend to proliferate more rapidly, resulting in an increased incidence of local recurrences up to malignant meningiomatosis.
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References
Bachrach U (1976) Polyamines as chemical markers of malignancy. Ital J Biochem 25:77–93
Böker DK, Stark HJ (1988) The proliferation rate of intracranial tumors as defined by the monoclonal antibody KI 67. Application of the method to paraffin embedded specimens. Neurosurg Rev 11:267–272
Burger PC, Shibata T, Kleihues P (1986) The use of the monoclonal antibody Ki-67 in the identification of proliferating cells: application to surgical neuropathology. Am J Surg Pathol 10:611–617
Deckert M, Reifenberger G, Wechsler W (1989) Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67. J Cancer Res Clin Oncol 115:179–188
Ermestus RI, Röhn G, Paschen W (1991) Polyamine metabolism in experimental brain tumors of rat. J Cereb Blood Flow Metab 11Suppl 2:548
Emestus RI, Röhn G, Schröder R, Klug N, Hossmann KA, Paschen W (1992) Activity of ornithine decarboxylase (ODC) and polyamine levels as biochemical markers of malignacy in brain tumors. Acta Histochem Suppl (Jena) 42:159–164
Gerdes J, Schwab U,. Lemke H, Stein H (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31:13–20
Gerdes J, Lemke H, Baisch H, Wacker H, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 31:1710–1715
Giangasparo F, Doglioni C, Rivano MT, Pileri S, Gerdes J, Stein H (1987) Growth fraction in human brain tumors defined by the monoclonal antibody Ki-67. Acta Neuropathol (Berl) 74:179–182
Horn Y, Beal SL, Walach N, Lubich WP, Spigel L, Marton LJ (1982) Further evidence for the use of polyamines as biochemical markers for malignant tumors. Cancer Res 42:3248–3251
Iwaki T, Takeshita I, Fukui M, Kitamaura K (1987) Cell kinetics of the malignant evolution of meningoendothelial meningioma. Acta Neuropathol (Berl) 74:243–247
Jänne J, Pösö H, Raina A (1978) Polyamines in rapid growth and cancer. Biochim Biophys Acta 473:241–293
Louis DN, Edgerton S, Thor AD, Hedley-Whyte ET (1991) Proliferating cell nuclear antigen and Ki-67 immunohistochemistry in brain tumors: a comparative study. Acta Neuropathol (Berl) 81:675–679
Morimura T, Kitz K, Stein H, Budka H (1991) Determination of proliferative activities in human brain tumor specimens: a comparison of three methods. J Neurooncol 10:1–11
Ostertag CB, Volk B, Shibata T, Burger P, Kleihues P (1987) The monoclonal antibody Ki-67 as a marker for proliferating cells in stereotactic biopsis of brain tumours. Acta Neurochir (Wien) 89:117–121
Paschen W, Röhn G, Meese CO, Djuricic B, Schmidt-Kastner R (1988) Polyamine metabolism in reversible cerebral ischemia. Effect of α-difluoromethylomithine. Brain Res 453:9–16
Patsouris E, Stocker U, Kallmeyer V, Keiditsch E, Mehraein P, Stavrou D (1988) Relationship between Ki-67 positive cells, growth rate and histological type of human intracranial tumors. Anticancer Res 8:537–544
Plate KH, Rüschoff J, Behnke J, Mennel HD (1990) Proliferative potential of human brain tumours as assessed by nucleolar organizer regions (AgNORs) and Ki-67-immunoreactivity. Acta Neurochir (Wien) 104:103–109
Roggendorf W, Schuster T, Pfeiffer J (1987) Proliferative potential of meningiomas determined with the monoclonal antibody Ki-67. Acta Neuropathol (Berl) 73:361–364
Russell DH, Haddox MK (1978) Cyclic AMP-mediated induction of ornithine decarboxylase in normal and neoplastic growth. Adv Enzyme Regul 17:61–79
Scalabrino G, Ferioli ME (1985) Degree of enhancement of polyamine biosynthetic decarboxylase activities in human tumors: a useful new index of degree of malignancy. Cancer Detect Prev 8:11–16
Schröder R, Bien K, Kott R, Meyer I, Vössing R (1991) The relationship between Ki-67 labelling and mitotic index in gliomas and meningiomas: demonstration of the variability of the intermitotic cycle time. Acta Neuropathol (Berl) 82:389–394
Shibata T, Burger PC, Kleihues P (1988) Ki-67 immunoperoxidase stain as a marker for the histological grading of nervous system tumours. Acta Neurochir Suppl (Wien) 43:103–106
Shibata T, Ostertag CB, Volk B (1989) Ki-67 PAP stain for histologic grading of brain tumors by squash preparations. No To Shinkei 41:55–60
Shiraishi T (1990) Cell kinetic analysis of brain tumors using the monoclonal antibody Ki-67: in vitro and in situ study. Acta Med Okayama 43:187–201
Zülch KJ (1986) Brain tumors. Their biology and pathology. 3rd edn. Springer, Berlin Heidelberg New York
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Ernestus, R.I., Schröder, R., Röhn, G., Klug, N., Hossmann, K.A., Paschen, W. (1993). Activity of Ornithine Decarboxylase and Ki-67 Index in Meningiomas. In: Lorenz, R., Klinger, M., Brock, M. (eds) Intracerebral Hemorrhage Hydrocephalus malresorptivus Peripheral Nerves. Advances in Neurosurgery, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77997-8_57
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DOI: https://doi.org/10.1007/978-3-642-77997-8_57
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