Serum Neuron-Specific Enolase in Ischemic Brain Damage
Neuron-specific enolase (NSE) represents the y,y isoenzyme of the dimeric protein enolase which is a soluble enzyme of the glycolytical pathway. Physiologically, NSE is specifically present in neuronal cytoplasm and dendrites, and in cells of the amine precursor uptake and decarboxylation (APUD) cell system . Since patients suffering from APUDomas, neuroblastomas, or small cell carcinoma of the lung show elevated NSE titers in serum, NSE has been clinically established as a diagnostic and prognostic marker in such neoplasms [1, 5, 8]. However, recently obtained immunohistochemical findings of a decrease in neuronal NSE immunoreactivity in experimental animals and humans following transient cerebral ischemia suggested cytoplasmic NSE loss due to ischemia [3, 6]. Previous studies have shown intracellular compounds, especially NSE, to accumulate in the extracellular fluid and cerebrospinal fluid (CSF) after ischemia . The present study was performed in order to clarify if neuronal NSE release in ischemic brain damage is accompanied by an increase of NSE levels in serum. Therefore, serum NSE was measured at various times after experimental transient forebrain ischemia followed by histological evaluation of ischemic neuronal damage.
KeywordsSmall Cell Carcinoma Global Cerebral Ischemia Forebrain Ischemia Ischemic Brain Damage Transient Cerebral Ischemia
Unable to display preview. Download preview PDF.
- 3.Horn M, Lang C, Schlote W (1991) Delayed neuronal death caused by cardiac arrest in man. Clin Neuropathol 10:270Google Scholar
- 5.Marangos PJ (1991) Neuron specific enolase as a clinical tool in neurologic and endocrine deseases. In: Gratzl M, Langley K (eds) Markers of neural and endocrine cells. VCH, Weinheim, pp 181–189Google Scholar
- 8.Wielders JPM, Bartels CT, Bank CMC, Meek JCE, van Dieijen-Visser MP, Brombacher PJ (1991) The diagnostic value of neuron-specific enolase and carcino-embryonic antigen analyses in patients with carcinoma of the lung. J Clin Chem Biochem 28:225–231Google Scholar