Hyperparathyroid and Hypoparathyroid Bone Disease

  • M. Peacock
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 107)

Abstract

Hyperparathyroid and hypoparathyroid diseases provide unique insights into the action of parathyroid hormone (PTH) on bone. Diseases of excess PTH arise either as a primary abnormality in hormone secretion, or as a compensatory response to a disorder of serum calcium homeostasis. Hypoparathyroidism usually arises from surgical removal of the parathyroids, although it may arise as an idiopathic disease. Uncommonly, the parathyroid receptor is defective, giving rise to increased PTH secretion but with failure of biological action.

Keywords

Adenoma Pancreatitis Perforation Cataract Calcitonin 

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References

  1. (1989) Recommended dietary allowances, 10th edn. National Academy Press, WashingtonGoogle Scholar
  2. (1991) Proceedings of the NIH Consensus Development Conference on diagnosis and management of asymptomatic primary hyperparathyroidism. Liebert, New YorkGoogle Scholar
  3. Aaron JE, Gallagher JC, Anderson J, Stasiak L, Longton EB, Nordin BEC, Nicholson M (1974) Frequency of osteomalacia and osteoporosis in fractures of the proximal femur. Lancet 1:229-233PubMedGoogle Scholar
  4. Adams JS, Clemens TL, Parrish JA, Holick MF (1982) Vitamin D synthesis and metabolism after ultraviolet radiation of normal and vitamin D-deficient subjects. N Engl J Med 306:722-725PubMedGoogle Scholar
  5. Ahn TG, Antonarakis SE, Kronenberg HM et al. (1986) Familial isolated hypopara- thyroidism: a molecular genetic analysis of 8 families with 23 affected persons. Medicine (Baltimore) 65:73-81Google Scholar
  6. Ahonen P (1985) Autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED): autosomal recessive inheritance. Clin Genet 27:535-542PubMedGoogle Scholar
  7. Akerstrom G, Malmaeus J, Bergstrom R (1984) Surgical anatomy of human para- thyroid glands. Surgery 95:14-21PubMedGoogle Scholar
  8. Akerstrom G, Rudberg C, Cyrimelius L et al. (1986) Histologic parathyroid adenoma and chief cell hyperphasia. Hum Pathol 17:520-527PubMedGoogle Scholar
  9. Albright F, Reifenstein EC (1948) The parathyroid glands and metabolic bone disease. Williams and Wilkins, BaltimoreGoogle Scholar
  10. Albright F, Forbes AP, Henneman PH (1952) Pseudopseudohypoparathyroidism. Trans Assoc Am Physicians 65:337PubMedGoogle Scholar
  11. Anderson S, Meyer TW, Brenner BM (1987) Mechanisms of age-associated glomerular sclerosis. In: Cameron JS, Nunez JFM (eds) Renal function and disease in the elderly. Butterworth, London, pp 49-66Google Scholar
  12. Andress DL, Norris KC, Coburn JW, Slatopolsky EA, Sherrard DJ (1989) Intravenous calcitriol in the treatment of refactory osteitis fibrosa cystica of chronic renal failure. N Engl J Med 274-279Google Scholar
  13. Arnaud CD (1973) Hyperparathyroidism and renal failure. Kidney Int 4:89-95PubMedGoogle Scholar
  14. Arnold A, Staunton CE, Kim HG, Gaz RD, Kronenberg HM (1988) Monoclonality and abnormal parathyroid hormone genes in parathyroid adenoma. N Engl J Med 318:658-662PubMedGoogle Scholar
  15. Arnold A, Kim HG, Gaz RD, Eddy RL, Fukushima R, Byers MG, Shous TB, Kronenberg HM (1989) Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest 83:2034-2040PubMedGoogle Scholar
  16. Arnold A, Horst SA, Gardella TJ, Baba H, Levine MA, Kronenberg HM (1990) Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism. J Clin Invest 86: 1084-1087PubMedGoogle Scholar
  17. Attie MF, Gill JR Jr, Stock JL et al. (1983) Urinary calcium excretion in familial hypocalciuric hypercalcemia: persistence of relative hypocalcuria after induction of hypoparathyroidism. J Clin Invest 72:667-676PubMedGoogle Scholar
  18. Baker LRI, Muir JW, Sharman VL, Abrams SML, Greenwood RN, Cattell WR, Goodwin FJ, Marsh FP, Adami S, Hately W, Hattersley LA, Morgan AG, Papapoulos SE, Revell PA, Tucker AK, Chaput de Saintonge DM, O’Riordan JLH (1986) Controlled trial of calcitriol in hemodialysis patients. Clin Nephrol 26(4): 185-191PubMedGoogle Scholar
  19. Baker LRI, Abrams SML, Roe CJ, Faugere M-C, Fanti P, Subayti Y, Malluche HH (1989) l,25(OH)2D3 administration in moderate renal failure: a prospective double-blind trial. Kidney Int 35:661-669PubMedGoogle Scholar
  20. Baker MR, McDonnell H, Peacock M, Nordin BEC (1979) Plasma 25-hydroxy vitamin D concentrations in patients with femoral fracture. Br Med J 1:589-591PubMedGoogle Scholar
  21. Baker MR, Peacock M, Nordin BEC (1980) The decline of vitamin D status with age. Age Ageing 9:249-252PubMedGoogle Scholar
  22. Bishop JM (1991) Molecular themes in oncogenesis. Cell 64:235-248PubMedGoogle Scholar
  23. Block G, Dresser CM, Hartman AM, Carroll MD (1985) Nutrient sources in the American diet: quantitative data from the Hanes II survey. Am J Epidemiol 122:13-26PubMedGoogle Scholar
  24. Bouillon RA, Auwerx JH, Lissens WD, Pelemans WK (1987) Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr 45:755-763PubMedGoogle Scholar
  25. Breslau NA, Moses AM, Pak CY (1983) Evidence for bone remodeling but lack of calcium mobilization response to parathyroid hormone in pseudohypopara- thyroidism. J Clin Endocrinol Metab 57:638-644PubMedGoogle Scholar
  26. Brezis M, Shaler O, Leibel B et al. (1982) The spectrum of parathyroid function in thalassaemia subjects with transfusional iron overload. Miner Electrolyte Metab 8:307PubMedGoogle Scholar
  27. Brooks MH, Bell NH, Love L, Stern PH, Orfei E, Queener SF, Hamstra AJ, DeLuca HF (1978) Vitamin D-dependent rickets, type II resistance of target organs to 1,25-dihydroxy vitamin D. N Engl J Med 298:996-999PubMedGoogle Scholar
  28. Buchanan JR, Myers CA, Greer RB (1988) Effect of declining renal function on bone density in aging women. Calcif Tissue Int 43:1-6PubMedGoogle Scholar
  29. Burch WM, Posillico JT (1983) Hypoparathyroidism after 1-131 therapy with subsequent return of parathyroid function. J Clin Endocrinol Metab 57:398PubMedGoogle Scholar
  30. Cann CE, Prussia SG, Gordon GS (1979) Aluminum uptake by the parathyroid glands. J Clin Endocrinol Metab 49:543-545PubMedGoogle Scholar
  31. Carpenter TO, Carnes DL, Anast CS (1983) Hypoparathyroidism in Wilson’s disease. N Engl J Med 309:873PubMedGoogle Scholar
  32. Castleman B, Kibble B (1963) Case records of the Massachusetts General Hospital. Case 29. N Engl J Med 268:943-953Google Scholar
  33. Chalmers J, Irvine GB (1988) Fractures of the femoral neck in elderly patients with hyperparathyroidism. Clin Orthop 125-130Google Scholar
  34. Chapman K (1971) Osteomalacia in Iran. J Obstet Gynaecol Br Commonw 78: 851-860Google Scholar
  35. Chapuy MC, Durr F, Chapuy P (1983) Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol levels. J Gerontol 38:19-22PubMedGoogle Scholar
  36. Chapuy MC, Chapuy P, Meunier PJ (1987) Calcium and vitamin D supplements: effects on calcium metabolism in elderly people. Am J Clin Nutr 46:324-328PubMedGoogle Scholar
  37. Charles P, Eriksen EF, Mosekilde L, Meisen F, Jensen FT (1987) Bone turnover and balance evaluated by a combined calcium balance and 47calcium kinetic study and dynamic histomorphometry. Metabolism 36:1118-1124PubMedGoogle Scholar
  38. Christensson T, Hellstrom K, Wengle B, Alveryd A, Wiland B (1976) Prevalence of hypercalcemia in a health screening in Stockholm. Acta Med Scand 200:131-137PubMedGoogle Scholar
  39. Christensson T, Hellstrom K, Wengle B (1977) Hypercalcemia and primary hyper- parathyroidism. Arch Intern Med 137:1138-1142PubMedGoogle Scholar
  40. Clark OH, Wilkes W, Siperstein AE, Duh Q-Y (1991) Diagnosis and management of asymptomatic hyperparathyroidism: safety, efficacy, and deficiencies in our knowledge. J Bone Miner Res 6 Suppl 2:S135-S142Google Scholar
  41. Clemens T, Zhou X, Myles M, Endres D, Lindsay R (1986) Serum vitamin D2 and vitamin D3 metabolite concentrations and absorption of vitamin D2 in elderly subjects. J Clin Endocrinol Metab 63(3):656-660PubMedGoogle Scholar
  42. Coburn JW, Hartenbower DL, Massry SG (1973) Intestinal absorption of calcium and the effect of renal insufficiency. Kidney Int 4:96-104PubMedGoogle Scholar
  43. Cochran M, Platts MM, Moorhead PJ, Buxton H (1981) Spontaneous hypercalcaemia in maintenance dialysis patients: an association with a typical osteomalacia and fracture. Miner Electrolyte Metab 5:280-286Google Scholar
  44. Cohen J, Gierlowski TC, Schneider AB (1990) A prospective study of hyperpara- thyroidism in individuals exposed to radiation in childhood. JAMA 264:581-584PubMedGoogle Scholar
  45. Compston JE, Ayers AB, Horon LWL, Tighe JR, Creamer B (1978a) Osteomalacia after small bowel resection. Lancet 1:9-12PubMedGoogle Scholar
  46. Compston JE, Laker MF, Woodhead JS (1978b) Bone disease after jejuno-ileal bypass for obesity. Lancet 2:1-4PubMedGoogle Scholar
  47. Corless D, Beer M, Boucher BJ, Gupta SP, Cohen RD (1975) Vitamin D status in long-stay geriatric patients. Lancet 1:1404-1406PubMedGoogle Scholar
  48. Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, Mascioli SR, Scott JC, Seeley DG, Steiger P, Vogt TM (1990) Appendicular bone density and age predict hip fracture in women. JAMA 263:665-668PubMedGoogle Scholar
  49. Dandona P, Menon RK, Shenoy R, Houlder S, Thomas M, Mallinson WJW (1986) Low 1,25-dihydroxyvitamin D, secondary hyperparathyroidism, and normal osteocalcin in elderly subjects. J Clin Endocrinol Metab 63(2):459-462PubMedGoogle Scholar
  50. Dauphine RT, Riggs BL, Scholz DA (1975) Back pain and vertebral crush fractures: an unemphasized mode of presentation for primary hyperparathyroidism. Ann Intern Med 83:365-367PubMedGoogle Scholar
  51. Davies DR, Dent CE, Willcox A (1956) Hyperparathyroidism and steatorthsea. Br Med J 2:1133-1137PubMedGoogle Scholar
  52. Davies DR, Dent CE, Watson L (1968) Tertiary hyperparathyroidism. Br Med J 2:395-399Google Scholar
  53. Dawson-Hughes B (1991) Calcium supplementation and bone loss: a review of controlled clinical trials. Am J Clin Nutr 54 Suppl:274S-280SPubMedGoogle Scholar
  54. Dawson-Hughes B, Jacques P, Shipp C (1987) Dietary calcium intake and bone loss from the spine in healthy postmenopausal women. Am J Clin Nutr 46:685-687PubMedGoogle Scholar
  55. Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 323:878-883PubMedGoogle Scholar
  56. Debnam JW, Bates ML, Kopelman RC, Teitelbaum SL (1977) Radiological/ pathological correlations in uremic bone disease. Diagn Radiol 125:653-658Google Scholar
  57. Deller DJ, Begley MD (1983) Calcium metabolism and the bones after partial gastrectomy. I. Clinical features and radiology of the bones. Australas Ann Med 12:282-294Google Scholar
  58. Delmas PD, Demlaux B, Malaval L et al. (1986) Serum bone gamma carboxy- lutamic acid containing protein in primary hyperparathyroidism and maligant hypercalcemia. Comparison with bone histomorphometry. J Clin Invest 77:985PubMedGoogle Scholar
  59. Delmez JA, Tindira C, Grooms P, Dusso A, Windus DW, Slatopolsky E (1989) Parathyroid hormone suppression by intravenous 1,25dihydroxyvitamin D. J Clin Invest 83:1349-1355PubMedGoogle Scholar
  60. Dent DM, Miller JL, Klatt L, Barron J (1987) The incidence and causes of hypercalcemia. Postgrad Med J 63:745-750PubMedGoogle Scholar
  61. Dominquez JM, Mautalln CA, Rodo JE, Barcat JA, Molins ME (1970) Tertiary hyperparathyroidism diagnosed after renal homotransplantation. Am J Med 49:423-428Google Scholar
  62. Drezner MK, Nelson FA (1983) Pseudohypoparathyroidism. In: Stanbury JB (ed) The metabolic basis of inherited disease. McGraw-Hill, New York, p 1508Google Scholar
  63. Driscoll RH, Meredith SC, Wagonfeld JW, Rosenberg IH (1977) Bone histology and vitamin D status in Crohn’s disease. Assessment of vitamin D therapy. Gastroenterology 72:1051Google Scholar
  64. Drueke T (1980) Dialysis osteomalacia and aluminium intoxication. Nephron 26: 207-210PubMedGoogle Scholar
  65. Duda RJ Jr, Kumar R, Nelson K, Zinsmeister AR, Mann KG, Riggs BL (1987) 1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women. J Clin Invest 79:1249-1253PubMedGoogle Scholar
  66. Eastwood JB, Daly A, Carter GD, Alaghband-Zahek, DeWardener HE (1979) Plasma 25-hydroxy vitamin D in normal subjects and patients with terminal renal failure, on maintenance haemodialysis and after transplantation. Clin Sci 57:473PubMedGoogle Scholar
  67. Eeckhout E, Verbeelen D, Sennesael J, Kaufman I, Jonckheer MH (1989) Monitoring of bone mineral content in patients on regular hemodialysis. Nephron 52:158-161PubMedGoogle Scholar
  68. Ellis HA, Pierides AM, Feest TG, Ward MK, Kerr DNS (1977) Histopathology of renal osteodystrophy with particular reference to the effects of 1-hydroxy vitamin D3 in patients treated by long-term dialysis. Clin Endocrinol (Oxf) 7:31S-38SGoogle Scholar
  69. Epstein S, Bryce G, Hinman JW, Miller ON, Riggs BL, Hui SL, Johnston CC Jr (1986) The influence of age on bone mineral regulating hormones. Bone 7:421-425PubMedGoogle Scholar
  70. Firth RG, Grant CS, Riggs BL (1985) Development of hypercalcemic hyperparathy- roidism after long-term phosphate supplementation in hypophosphatemic osteomalacia. Am J Med 78:669-673PubMedGoogle Scholar
  71. Francis RM, Peacock M (1987) Local action of oral 1,25-dihydroxycholecalciferol on calcium absorption in osteoporosis. Am J Clin Nutr 46:315-318PubMedGoogle Scholar
  72. Francis RM, Peacock M, Storer JH, Davies AEJ, Brown WB, Nordin BEC (1983) Calcium malabsorption in the elderly: the effect of treatment with oral 25 hydroxyvitamin D3. Eur J Clin Invest 13:391-396PubMedGoogle Scholar
  73. Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BEC (1984) Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci 66:103-107PubMedGoogle Scholar
  74. Fraser DR, Kooh SW, Kind HP, Holick MF, Tanaka Y, DeLuca HF (1973) Pathogenesis of hereditary vitamin D dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1,25 dihydroxyvitamin D. N Engl J Med 289:817-822PubMedGoogle Scholar
  75. Friedman E, Sakaguchhi K, Bale AE, Falchetti A, Streeten E, Zimering MB, Weinstein LS, McBride WD, Nakamura Y, Brandi M-L, Norton JA, Aurbach GD, Spiegel AM, Marx SJ (1989) Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med 321:213-218PubMedGoogle Scholar
  76. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF (1979) Intestinal calcium absorption and serum vitamin D. J Clin Invest 64:729-736PubMedGoogle Scholar
  77. Gallagher JC, Melton LJ, Riggs BL, Bergstrath E, DeLuca HF (1980a) Epidemiology of fractures of the proximal femur in Rochester, Minnesota. Clin Orthop 150:163-171PubMedGoogle Scholar
  78. Gallagher JC, Riggs BL, Jerpbak CM, Arnaud CD (1980b) The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women. J Lab Clin Med 95(3):373-385PubMedGoogle Scholar
  79. Gardseil P, Johnell O, Nilsson BE (1989) Predicting fracture in women by using forearm bone densitometry. Calcif Tissue Int 44:235-242Google Scholar
  80. Genant HK, Heck LL, Lanzl LH, Rossman K, VanderHorst J, Paloyan E (1973) Primary hyperparathyroidism. Diagn Radiol 109:513-524Google Scholar
  81. Ghandur-Mnaymneh L, Kimura N (1984) The parathyroid adenoma: a histopath- ological definition with a study of 172 cases of primary hyperparathyroidism. Am J Pathol 115:70-83PubMedGoogle Scholar
  82. Glorieux FH, Marie PJ, Pettifor JM, Delvin EE (1980) Bone response to phosphate salts, ergocalciferol and calcitriol in hypophosphatemie vitamin D-resistant rickets. N Engl J Med 303:1023-1031PubMedGoogle Scholar
  83. Goodman WG, Henry DA, Horst R et al. (1984) Parenteral aluminium administra- tion in the dog: induction of osteomalacia and effect on vitamin D metabolism. Kidney Int 25:370-375PubMedGoogle Scholar
  84. Graham K, Williams BO, Rowe MJ (1979) Idiopathic hypoparathyroidism: a cause of fits in the elderly. Br Med J 1:1460-1461PubMedGoogle Scholar
  85. Gray RW, Wilz DR, Caldas AE, Lemann J (1977) The importance of phosphate in regulating plasma 1,25(OH)2 vitamin D levels in humans: studies in healthy subjects in calcium stone formers and patients with primary hyperparathyroidism. J Clin Endocrinol Metab 45:299-306PubMedGoogle Scholar
  86. Greenfield BG (1990a) Hyperparathyroidism. In: Greenfield GB (ed) Radiology of bone diseases, 5th edn. Lippincott, Philadelphia, pp 43-61Google Scholar
  87. Greenfield GB (1990b) Renal osteodystrophy. In: Greenfield GB (ed) Radiology of bone diseases, 5th edn. Lippincott, Philadelphia, pp 62-73Google Scholar
  88. Greenfield GB (ed) (1990c) Radiology of bone diseases, 5th edn. Lippincott, PhiladelphiaGoogle Scholar
  89. Habener JF, Potts JT Jr (1990) Primary hyperparathyroidism. In: Avioli LV, Krane SM (eds) Metabolie bone disease. Saunders, Philadelphia, pp 475-545Google Scholar
  90. Hannon RR, Shorr E, McClellan WS, Dubois EF (1930) A case of osteites fibrosa cystica (osteomalacia?) with evidence of hyperactivity of the parathyroid bodies, metabolic study I. J Clin Invest 8:215-277PubMedGoogle Scholar
  91. Haussier MR, McCain TA (1977) Vitamin D metabolism and action. N Engl J Med 297:974-983, 1041-1050Google Scholar
  92. Heath H III (1991) Clinical spectrum of primary hyperparathyroidism: evolution with changes in medical practice and technology. J Bone Miner Res 6 Suppl 2:S63-S70Google Scholar
  93. Heath H III, Hodgson SF, Kennedy MA (1980) Primary hyperparathyroidism: incidence, morbidity, and potential economic impact in a community. N Engl J Med 302(4): 189-193PubMedGoogle Scholar
  94. Herbert LA, Lemann J, Petersen JR, Lennon EJ (1966) Studies of the mechanism by which phosphate infusion lowers serum calcium concentration. J Clin Invest 45:1886-1894Google Scholar
  95. Hercz G, Kraut JA, Andress DA et al. (1986) Use of calcium carbonate as a phosphate binder in dialysis patients. Mineral Electrolyte Metab 12:314-319Google Scholar
  96. Hesp R, Hulme P, Williams D, Reeve J (1981) The relationship between changes in femoral bone density and calcium balance in patients with involutional osteoporosis treated with human parathyroid hormone fragment (hPTH 1-34). Metab Bone Dis Relat Res 2:331-334Google Scholar
  97. Hock JM, Hummert JR, Boyce R, Fonseca J, Raisz LG (1989) Resorption is not essential for the stimulation of bone growth by hPTH-(1-34) in rats in vivo. J Bone Miner Res 4:449-458PubMedGoogle Scholar
  98. Hodkinson HM, Round P, Stanton BR, Morgan C (1973) Sunlight, vitamin D and osteomalacia in the elderly. Lancet 1:910-912PubMedGoogle Scholar
  99. Hodsman AB (1989) Effects of cyclical therapy of osteoporosis using an oral regimen of inorganic phosphate and sodium etidronate: a clinical and bone histomorphometric study. Bone Miner 5:201-212PubMedGoogle Scholar
  100. Hodsman AB, Sherrard DJ, Alfrey AC et al. (1982) Bone aluminium and histomor- phometric features of renal osteodystrophy. J Clin Endocrinol Metab 54:539–546PubMedGoogle Scholar
  101. Holick MF, Matsuoka LY, Wortsman J (1989) Age, vitamin D, and solar ultraviolet. Lancet 11Google Scholar
  102. Hordon LD, Peacock M (1987) Vitamin D metabolism in women with femoral neck fracture. Bone Miner 2:413-426PubMedGoogle Scholar
  103. Hordon LD, Peacock M (1990) Osteomalacia and osteoporosis in femoral neck fracture. Bone Miner 11:247-259PubMedGoogle Scholar
  104. Hori M, Uzawa T, Morita K, Noda T, Takahashi H, Inoue J (1988) Effect of human parathyroid hormone (PTH(l-34)) on experimental osteopenia of rats induced by ovariectomy. Bone Miner 3:193-199PubMedGoogle Scholar
  105. Horsman A, Marshall DH, Peacock M (1985) A stochastic model of age-related bone loss and fractures. Clin Orthop 195:207-215PubMedGoogle Scholar
  106. Hossain M, Smith DA, Nordin BEC (1970) Parathyroid activity and postmenopausal osteoporosis. Lancet 1:809-811PubMedGoogle Scholar
  107. Hughes MR, Malloy PJ, O’Malley BW, Pike JW, Feldman D (1991) Genetic defects of the 1,25-dihydroxyvitamin D3 receptor. J Recept Res 11:699-716PubMedGoogle Scholar
  108. Hui SL, Slemenda CW, Johnston CC Jr (1989) Baseline measurement of bone mass predicts fracture in white women. Ann Intern Med 111:355-361PubMedGoogle Scholar
  109. Huvos AG (1991) Giant-cell tumor of bone. In: Huvos AG (ed) Bone tumors. Saunders, Philadelphia, pp 429-467Google Scholar
  110. Ireland P, Fordtran JS (1973) Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest 52:2672–2681PubMedGoogle Scholar
  111. Jensen PS, Kliger AS (1977) Early radiographic manifestations by secondary hyper- parathyroidism associated with chronic renal disease. Diagn Radiol 125:645-652Google Scholar
  112. Joborn C, Rastad J, Stalberg E, Akerstrom G, Ljunghall S (1989) Muscle function in patients with primary hyperparathyroidism. Muscle Nerve 12:87-94PubMedGoogle Scholar
  113. Johnston CC, Norton J, Khairi MR, Kernek C, Edouard C, Arlot M, Meunier PJ (1985) Heterogeneity of fracture syndromes in postmenopausal women. J Clin Endocrinol Metab 61:551–556PubMedGoogle Scholar
  114. Johnston CC, Peacock M, Meunier P (1987) Osteomalacia as a risk factor for hip fractures in the U.S.A. In: Christiansen C, Johansen JS, Riis BJ (eds) Osteoporosis 1987. Norhaven, Viborg, pp 317-320Google Scholar
  115. Johnston CC, Melton LJ III, Lindsay R, Eddy DM (1989) Clinical indications for bone mass measurements. J Bone Miner Res 4:1-27Google Scholar
  116. Jung RT, Davie M, Hunter S, Chalmers TM (1978) Ultraviolet light: an effective treatment of osteomalacia in malabsorption. Br Med J 1:1668-1669PubMedGoogle Scholar
  117. Kleeman CR, Massry SG, Coburn JW, Popovtzer MM (1969) Renal osteodystrophy, soft tissue calcification and disturbed divalent ion metabolism in chronic renal failure. Arch Intern Med 124:262PubMedGoogle Scholar
  118. Kochersberger G, Buckley NJ, Leight GS, Martinez S, Studenski S, Volger J, Lyles KW (1987) What is the clinical significance of bone loss in primary hyperparathyroidism? Arch Intern Med 147:1951-1953PubMedGoogle Scholar
  119. Kochersberger G, Westlund R, Lyles KW (1991) The metabolic effects of calcium supplementation in the elderly. J Am Geriatr Soc 39:192-196PubMedGoogle Scholar
  120. Kokowicz MA, Melton J III, Cedel SL, O’Fallon WM, Riggs BL (1990) Effect of age on variables relating to calcium and phosphorus metabolism in women. J Bone Miner Res 5:345-352Google Scholar
  121. Krall EA, Sahyoun N, Tannenbaum S, Dallal GE, Dawson-Hughes B (1989) Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med 321:1777-1783PubMedGoogle Scholar
  122. Kumar R (1984) Metabolism of 1,25-dihydroxy-vitamin D3. Physiol Rev 64:478–504PubMedGoogle Scholar
  123. Labuda M, Morgan K, Glorieux FH (1990) Mapping autosomal recessive vitamin D dependency type I to chromosome 12q14 by linkage analysis. Am J Hum Genet 47:28-36PubMedGoogle Scholar
  124. Lafferty FW (1991) Differential diagnosis of hypercalcemia. J Bone Miner Res 6 Suppl 2:S51-S59Google Scholar
  125. Lafferty FW, Hubay CA (1989) Primary hyperparathyroidism. A review of the long- term surgical and nonsurgical morbidities as a basis for a rational approach to treatment. Arch Intern Med 149:789-796PubMedGoogle Scholar
  126. Larsson K, Lindh E, Lind L, Persson I, Ljunghall S (1989) Increased fracture risk in hypercalcemia. Bone mineral content measured in hyperparathyroidism. Acta Orthop Scand 60:268-270PubMedGoogle Scholar
  127. Law WM Jr, Heath H (1985) Familial benign hypercalcemia (hypocalciuric hyper- calcemia). Clinical and pathogenetic studies in 21 families. Ann Intern Med 102:511-519PubMedGoogle Scholar
  128. Law WM Jr, Carney JA, Health H III (1984) Parathyroid glands in familial benign hypercalcemia (hypocalciuric hypercalcemia). Am J Med 76:1021-1026PubMedGoogle Scholar
  129. Lawoyin S, Sismilich S, Browne R, Pak CYC (1979) Bone mineral content in patients with calcium urolithiasis. Metabolism 28:1250-1254PubMedGoogle Scholar
  130. Lawson DEM, Paul AA, Black AE, Cole TJ, Mandel AR, Davie M (1979) Relative contributions of diet and sunlight to vitamin D state in the elderly. Br Med J 1:303-305Google Scholar
  131. Leppla DC, Snyder W, Pak CY (1982) Sequential changes in bone density before and after parathyroidectomy in primary hyperparathyroidism. Invest Radiol 17:604-606PubMedGoogle Scholar
  132. Levine MA, Aurbach GD (1989) Pseudohypoparathyroidism. In: DeGroot LJ (ed) Endocrinology. Saunders, Philadelphia, pp 1065-1079Google Scholar
  133. Liberman UA, Samuel R, Halabe A et al. (1980) End-organ resistance to 1,25 dihydroxycholecalciferol. Lancet 1:504-506PubMedGoogle Scholar
  134. Lindergard B (1981) Changes in bone mineral content evaluated by photon absorptiometry before the start of active uremia treatment. Clin Nephrol 16:126-130PubMedGoogle Scholar
  135. Lips P, Netelenbos JC, Jongen M, van Ginkel FC, Althuis AL, van Schaik CL, van der Vijgh WJF, Vermeider JPW, van der Meer C (1982) Histomorphometric profile and vitamin D status in patients with femoral neck fracture. Metab Bone Dis Relat Res 4(2):85-93PubMedGoogle Scholar
  136. Lips P, Wiersinga A, van Ginkel FC, Jongen MJM, Netelenbos JC, Hackeng WHL, Delmas PD, van der Vighn WJF (1988) The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 67:644-650PubMedGoogle Scholar
  137. Liu CC, Kalu DN (1990) Human parathyroid hormone-(1-34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats. J Bone Miner Res 5:973-982PubMedGoogle Scholar
  138. Liu CC, Kalu DN, Salerno E, Echon R, Hollis BW, Ray M (1991) Preexisting bone loss associated with ovariectomy in rats is reversed by parathyroid hormone. J Bone Miner Res 6:1071-1080PubMedGoogle Scholar
  139. Ljunghall S, Jakobsson S, Joborn C, Palmér M, Rastad J, Åkerström G (1991) Longitudinal studies of mild primary hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S111–S116Google Scholar
  140. MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536-1538PubMedGoogle Scholar
  141. Malmaeus J, Granberg P-O, Halvosen J, Akerstrom G, Johannson H (1988) Parathyroid surgery in Scandinavia. Acta Chir Scand 154:409-413PubMedGoogle Scholar
  142. Mandl F (1926) Klinisches und Experimentelles zur Frage der lokalisierten Ostitis fibrosa. B. Die generaliserte Form der Ostitis fibrosia. Arch Klin Chir 143:245Google Scholar
  143. Martin P, Bergmann P, Gillet C, Fuss M, Corvilain J, van Geertruyden J (1990) Long-term irreversibility of bone loss after surgery for primary hyper- parathyroidism. Arch Intern Med 150:1495-1497PubMedGoogle Scholar
  144. Marx SJ (1991) Etiologies of parathyroid gland dysfunction in primary hyperpara- thyroidism. J Bone Miner Res 6 Suppl 2:S19-S24Google Scholar
  145. Massry SG, Stein R, Garty J et al. (1975) Skeletal resistance to the calcemic action of parathyroid hormone in uremia. Role of l,25(OH)2D3 (Abstr). Kidney Int 1:467-474Google Scholar
  146. Matloff DS, Kaplan MM, Neer RM et al. (1982) Osteoporosis in primary biliary cirrhosis: effects of 25-hydroxyvitamin D3 treatment. Gastroenterology 83:97-102PubMedGoogle Scholar
  147. Mautalen C, Reyes HR, Ghiringhelli G, Fromm G (1986) Cortical mineral content in primary hyperparathyroidism. Changes after parathyroidectomy. Acta Endocrinol (Copenh) 111:494-497Google Scholar
  148. Mayer GP, Hurst JG (1878) Sigmoidal relationship between parathyroid hormone secretion rates and plasma calcium concentration in calves. Endocrinology 102: 1803-1807Google Scholar
  149. McKenna MJ, Freany R, Meade A, Muldowney FP (1985) Hypovitamin D and elevated serum alkaline phosphatase in elderly Irish people. Am J Clin Nutr 41:101PubMedGoogle Scholar
  150. Melton LJ III (1991) Epidemiology of primary hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S25-S30PubMedGoogle Scholar
  151. Memmos DE, Eastwood JB, Tarner B et al. (1982) Double-blind trial of oral 1,25- dihydroxy vitamin D3 versus placebo in asymptomatic hyperparathyroidism in patients receiving maintenance haemodialysis. Br Med J 282:1919-1924Google Scholar
  152. Meredith SC, Rosenberg IH (1980) Gastrointestinal hepatic disorders and oste- omalacia. Clin Endocrinol Metab 9:131-150PubMedGoogle Scholar
  153. Miller JD, Bowker BM, Cole DEC et al. (1983) DeGeorge’s syndrome in monozygotic twins. Am J Dis Child 137:438-440PubMedGoogle Scholar
  154. Mirra JM (1989) Brown tumor of hyperparathyroidism. In: Mirra JM (ed) Bone tumors. Lea and Febiger, Philadelphia, pp 1785-1799Google Scholar
  155. Morgan DB, Hunt G, Pasterson CR (1970) The osteomalacia syndrome after stomach operations. Q J Med 34:394-410Google Scholar
  156. Mundy GR, Core DH, Fisken R (1980) Primary hyperparathyroidism: changes in the pattern of clinical presentation. Lancet 1:1317–1321PubMedGoogle Scholar
  157. Murray TM, Peacock M, Powell D, Manchik JM, Potts JT (1972) Non-autonomy of hormone secretion in primary hyperparathyroidism. Clin Endocrinol (Oxf) 1:235-246Google Scholar
  158. Neer RM, Slovik DM, Daly M, Lo C, Potts JT, Jr, Nussbaum SR (1990) Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol. In: Christiansen C, Overgaard K (eds) Osteoporosis 1990. Proceedings of the Third International Symposium on Osteoporosis. Osteopress, Copenhagen, pp 1314-1317Google Scholar
  159. Newton-John H, Morgan B (1970) The loss of bone with age: osteoporosis and fractures. Clin Orthop 71:229-252PubMedGoogle Scholar
  160. Nordal KP, Dahl E (1988) Low dose calcitriol versus placebo in patients with predialysis chronic renal failure. J Clin Endocrinol Metab 67:929-936PubMedGoogle Scholar
  161. Nordin BEC, Heaney RP (1990) Calcium supplementation of the diet: justified by present evidence. Br Med J 300:1056-1060Google Scholar
  162. Nordin BEC, Wilkinson R, Marshall DH, Gallagher JC, Williams A, Peacock M (1976) Calcium absorption in the elderly. Calc Tiss Res 21:442-451Google Scholar
  163. Nordin BEC, Peacock M, Aaron J, Crilly RG, Heyburn PJ, Horsman A, Marshall DH (1980) Osteoporosis and osteomalacia. Clin Endocrinol Metab 9:177-205PubMedGoogle Scholar
  164. Nordin BEC, Baker MR, Horsman A, Peacock M (1985) A prospective trial of the effect of vitamin D supplementation on metacarpal bone loss in elderly women. Am J Clin Nutr 42:470-474PubMedGoogle Scholar
  165. Nussbaum SR, Potts JT Jr (1991) Immunoassays for parathyroid hormone 1-84 in the diagnosis of hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S43-S50Google Scholar
  166. Nussbaum SR, Gaz RD, Arnold A (1990) Hypercalcemia and ectopic excretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone. N Engl J Med 323:1324-1328PubMedGoogle Scholar
  167. Omdahl JL, Garry PJ, Hunsaker LA, Hunt WC, Goodwin JS (1982) Nutritional status in a healthy elderly population: vitamin D. Am J Clin Nutr 36:1225-1233PubMedGoogle Scholar
  168. Orr-Walker B, Harris R, Holdaway IM, Foote G, Reid IR (1990) High per- ipheral and axial bone densities in a postmenopausal woman with untreated hypoparathyroidism. Postgrad Med J 66:1061-1063PubMedGoogle Scholar
  169. Orwoll ES, Meier DE (1986) Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. J Clin Endocrinol Metab 63:1262-1269PubMedGoogle Scholar
  170. Overton TR, Silverberg DS, Grace M et al. (1976) Bone demineralization in renal failure: a longitudinal study of the distal femur using photon absorptiometry. Br J Radiol 49:921-925PubMedGoogle Scholar
  171. Pak CYC (1990) Kidney stones: pathogenesis, diagnosis and therapy. In: Avioli LV, Krane SM (eds) Metabolic bone disease. Saunders, Philadelphia, pp 823-849Google Scholar
  172. Pak CYC, Galosy RA (1979) Fasting urinary calcium and adenosive 3, 5 mono- phosphate: a discriminant analysis for the identification of renal absorptive hypercalcuria. J Clin Endocrinol Metab 48:260-265PubMedGoogle Scholar
  173. Palmer M, Jakobsson G, Akerstrom G, Ljunghall S (1988) Prevalence of hyper- calcemia in a health survey: a 14-year-fellowship study of serum calcium values. Eur J Clin Invest 18:39-46PubMedGoogle Scholar
  174. Parfitt AM (1977) Metacarpal cortical dimensions in hypoparathyroidism, primary hyperparathyroidism and chronic renal failure. Calcif Tissue Res Suppl. S329–S331Google Scholar
  175. Parfitt AM (1990) Osteomalacia and related disorders. In: Avioli LV, Krane SM (eds) Metabolic bone disease. Saunders, Jovanovich, Philadelphia, pp 329-396Google Scholar
  176. Parfitt AM, Miller MJ, Frame B, Villanueva AR, Rao DS, Oliver I, Thompson DL (1978) Metabolic bone disease after intestinal bypass for treatment of obesity. Ann Intern Med 89:193-199PubMedGoogle Scholar
  177. Parfitt AM, Rao D, Stanciu J, Villanueva A, Kleerekoper M, Frame B (1985) Irreversible bone loss in osteomalacia. J Clin Invest 76:2403-2412PubMedGoogle Scholar
  178. Parisien M, Silverberg SJ, Shane E, de La Cruz L, Lindsay R, Bilezikian JP, Dempster DW (1990) The histomorphometry of bone in primary hyperpara- thyroidism: preservation of cancellous bone structure. J Clin Endocrinol Metab 70:930-938PubMedGoogle Scholar
  179. Parkinson IS, Ward MK, Feest TG et al. (1979) Fracturing dialysis osteodystrophy and dialysis encephalopathy: an epidemiological survey. Lancet 1:406-409PubMedGoogle Scholar
  180. Peacock M, Robertson WG, Nordin BEC (1969) Relation between serum and urinary calcium with particular reference to parathyroid activity. Lancet 384–386Google Scholar
  181. Peacock M (1976) Parathyroid hormone and calcitonin. In: Nordin BEC (ed) Calcium, phosphate and magnesium metabolism. Churchill Livingstone, Edinburgh, pp 405-443Google Scholar
  182. Peacock M (1978) The endocrine control of calcium and phosphorus metabolism. Medicine (Baltimore) 9:407-417Google Scholar
  183. Peacock M (1980) Hypercalcaemia and calcium homeostasis. Metab Bone Dis Rel Res 2:143-150Google Scholar
  184. Peacock M (1984) Osteomalacia and rickets. In: Nordin BEC (ed) Metabolic bone and stone disease. Churchill Livingstone, Edinburgh, pp 71–111Google Scholar
  185. Peacock M (1991) Interpretation of bone mass determinations as they relate to fracture: implications for asymptomatic primary hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S77-S82Google Scholar
  186. Peacock M, Hordon L (1989) Femoral fracture: the role of vitamin D. In: Kleerekoper M, Krane SM (eds) Clinical disorders of bone and mineral metabolism. Liebert, New York, pp 265-271Google Scholar
  187. Peacock M, Kradin RL (1981) A 76 year old women with intermittent hypercalcemia. Case records of the Massachusetts General Hospital. N Engl J Med 305: 1457-1464Google Scholar
  188. Peacock M, Robertson WG (1989) Urinary calcium stone disease. In: DeGroot LJ et al. (eds) Endocrinology. Saunders, Philadelphia, pp 1111-1132Google Scholar
  189. Peacock M, Aaron JE, Walker GS, Davison AM (1977a) Bone disease and hyper- parathyroidsm in chronic renal failure: the effect of 1 alpha hydroxy vitamin D3. Clin Endocrinol (Oxf) 7:73S-81SGoogle Scholar
  190. Peacock M, Heyburn PJ, Aaron JE et al. (1979) Osteomalacia: treated with 1- hydroxy or 1,25 dihydroxy vitamin D. In: Norman AW et al. (eds) Vitamin D, basic research and its clinical application. deGruyter, Berlin, pp 1177-1183Google Scholar
  191. Peacock M, Taylor GA, Brown W (1980) Plasma l,25(OH)2 D measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with primary hyperparathyroidism and renal failure. Clin Chim Acta 101:93-101PubMedGoogle Scholar
  192. Peacock M, Bambach CP, Robertson WG, Aaron JE, Hill GL (1981) Urinary stone formation in bowel disease. In: Smith LH, Robertson WG, Finlayson B (eds) Urolithiasis: clinical and basic research. Plenum, New York, pp 159-168Google Scholar
  193. Peacock M, Horsman A, Aaron JE, Marshall DH, Selby PL, Simpson M (1984) The role of parathyroid hormone in bone loss. In: Christiansen et al. (ed) Osteo- porosis. Aalborg Stifsbogtrykkeri, Aalborg, pp 463-468Google Scholar
  194. Peacock M, Selby PL, Francis RM, Brown WB, Hordon L (1985) Vitamin D deficiency, insufficiency, sufficiency and intoxication. What do they mean? In: Normal AW, Schaefer K, Grigoleit H-G, Herrath DV (eds) Sixth workshop on vitamin D. de Gruyter, Berlin pp 569-570Google Scholar
  195. Pierides AM (1977) The role of phosphate in renal bone disease. Clin Endocrinol (Oxf) 7:101S-107SGoogle Scholar
  196. Pierides AM, Ellis HA, Simpson W et al. (1976) Variable response to long term 1- hydroxycholecalciferol in haemodialysis osteodystrophy. Lancet 1:1903-1095Google Scholar
  197. Pike JW (1991) Vitamin D3 receptors: structure and function in transcription. Annu Rev Nutr 11:189-216PubMedGoogle Scholar
  198. Pipeleers-Marichal M, Somers G, Williams G et al. (1990) Gastrinomas in the duodenum of patients with multiple endocrine neoplasia type I and the Zollinger-Ellison syndrome. N Engl J Med 322:723-727PubMedGoogle Scholar
  199. Piraino B, Chen T, Cooperstein L, Segre G, Puschett J (1988) Fractures and vertebral bone mineral density in patients with renal osteodystrophy. Clin Nephrol 30:57-62PubMedGoogle Scholar
  200. Portale AA, Halloran BP, Murphy MM, Morris RC Jr (1986) Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxy vitamin D by determining its production rate in humans. J Clin Invest 77:7-12PubMedGoogle Scholar
  201. Potts JT (1990) Management of asymptomatic hyperparathyroidism. J Clin Endocrinol Metab 70:1489-1493PubMedGoogle Scholar
  202. Pugh DG (1951) Subperiosteal resorption of bone. A roentgenologic manifestation of primary hyperparathyroidism and renal osteodystrophy. AJR 66(4):577-586Google Scholar
  203. Rao DS (1985) Bone and mineral metabolism. In: Berk JE (ed) Bockus gastroenterology. Saunders, Philadelphia, pp 4629-4638Google Scholar
  204. Rao DS, Wilson RJ, Kleerekoper M, Parfitt AM (1988) Lack of biochemical progression or continuation of accelerated bone loss in mild asymptomatic primary hyperparathyroidism: evidence for biphasic disease course. J Clin Endocrinol Metab 67:1294-1298PubMedGoogle Scholar
  205. Rasmussen H, Pechet M, Anast C, Mazur A, Gertner J, Broadus AE (1981) Long term treatment of familial hypophosphatemic rickets with oral phosphate and 1 alpha-hydroxy vitamin D3. J Pediatr 99:16-25PubMedGoogle Scholar
  206. Rassmussen H, Bordier P, Marie P, Auquier L, Eisinger JB, Kuntz D et al. (1980) Effect of combined therapy with phosphate and calcitonin on bone volume in osteoporosis. Metab Bone Dis Relat Res 2:107-111Google Scholar
  207. Reeve J, Meunier PJ, Parsons JA, Bernat M, Bijvoet OLM, Courpron P, Edouard C, Klenerman L, Neer RM, Renier JC, Slovik D, Vismans FJFE, Potts JT Jr (1980) The anabolic effect of human parathyroid hormone fragment (hPTH 1- 34) therapy on trabecular bone in involutional osteoporosis: report of a multi- center trial. Br Med J 280:1340-1344PubMedGoogle Scholar
  208. Reichel H, Koeffler HP, Norman AW (1989) The role of the vitamin D endocrine system in health and disease. N Engl J Med 320(15):980-991PubMedGoogle Scholar
  209. Reiss E, Canterbury J, Egdahl RH (1968) Experience with a radioimmunoassay of parathyroid hormone in human sera. Trans Assoc Am Physiol 81:104-115Google Scholar
  210. Reiss E, Canterberry JM, Bercovile MA, Kaplan EL (1970) The role of phosphate in the secretion of parathyroid hormone in man. J Clin Invest 49:2146-2149PubMedGoogle Scholar
  211. Richardson ML, Pozzi-Mucelli RS, Kanter AS, Kolb FO, Ettinger B, Genant HK (1986) Bone mineral changes in primary hyperparathyroidism. Skeletal Radiol 15:85-95PubMedGoogle Scholar
  212. Rickers H, Christensen M, Rodbro P (1983) Bone mineral content in patients on prolonged maintenance hemodialysis: a three year follow-up study. Clin Nephrol 20:302-307PubMedGoogle Scholar
  213. Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314:1676–1686PubMedGoogle Scholar
  214. Riggs BL, Melton LJ III (1990) Clinical heterogeneity of involutional osteoporosis: implications for preventive therapy. J Clin Endocrinol Metab 70:1229-1232PubMedGoogle Scholar
  215. Rosen JF, Fleischman AR, Fineberg L, Hamstra A, DeLuca HF (1979) Rickets with alopecia, an inborn error of vitamin D metabolism, J Pediatr 94:729-735PubMedGoogle Scholar
  216. Rosen RA, Deshmukh SM (1985) Growth arrest recovery lines in hypoparathyroidism. Radiology 155:61-62PubMedGoogle Scholar
  217. Ross PD, Davis JW, Vogel JM, Wasnich RD (1990) A critical review of bone mass and the risk of fractures in osteoporosis. Calcif Tissue Int 46:149-161PubMedGoogle Scholar
  218. Roth SI (1971) Recent advances in parathyroid gland pathology. Am J Med 50: 612-622PubMedGoogle Scholar
  219. Rutherford WE, Bordier P, Marie P, Hruska K, Harter H, Greenwalt A, Blondin J, Haddad J, Bricker N, Slatopolsky E (1977) Phosphate control and 25-hydroxycholecalciferol administration in preventing experimental renal osteodystrophy in the dog. J Clin Invest 60:332-341PubMedGoogle Scholar
  220. Schantz A, Castleman B (1973) Parathyroid carcinoma: a study of 70 cases. Cancer 31:600-605PubMedGoogle Scholar
  221. Seeman E, Wahner HW, Offord KP, Kumar R, Johnson WJ, Riggs BL (1982) Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest 69:1302-1309PubMedGoogle Scholar
  222. Segre GV, Potts JT (1989) Differential diagnosis of hypercalcemia: methods and clinical applications of parathyroid assays. In: DeGroot LJ et al. (eds) Endocrinology. Saunders, Philadelphia, pp 984-1001Google Scholar
  223. Selby PL, Peacock M (1986) Ethinyl estradiol and norethindrone in the treatment of primary hyperparathyroidism in postmenopausal women. N Engl J Med 314: 1481-1485PubMedGoogle Scholar
  224. Shakhall K, Nicar MJ, Brater DC et al. (1985) Exaggerated natriuretic and calciuric response to hydrochlorothiazide in renal hypercalcuria but not in absorptive hypercalcuria. J Clin Endocrinol Metab 61:825-829Google Scholar
  225. Sherman SS, Hollis BW, Tobin JD (1990) Vitamin D status and related parameters in a healthy population: the effects of age, sex and season. J Clin Endocrinol Metab 71:405-413PubMedGoogle Scholar
  226. Sherrard DJ (1986) Renal osteodystrophy. Semin Nephrol 6:56-67PubMedGoogle Scholar
  227. Shock NW (1987) The kidney: a model for the study of aging in a physiological system. In: Cameron JS, Nunez JFM (eds) Renal function and disease in the elderly. Butterworth, London, pp 1-2Google Scholar
  228. Shukla S, Gillespy T, Thomas WC Jr (1990) The effect of hypoparathyroidism on the aging skeleton. J Am Geriatr Soc 38:884-888PubMedGoogle Scholar
  229. Silverberg SJ, Shane E, de La Cruz L, Dempster DW, Feldman F, Seldin D, Jacobs TP, Siris ES, Cafferty M, Parisien MV, Lindsay R, Clemens TL, Bilezikian JP (1989) Skeletal disease in primary hyperparathyroidism. J Bone Miner Res 4:283-291PubMedGoogle Scholar
  230. Slatopolsky E, Coburn JW (1990) Renal osteodystrophy. In: Avioli LV, Krane SM (eds) Metabolic bone disease. Saunders, Philadelphia, pp 452-474Google Scholar
  231. Slatopolsky E, Caglar S, Gradowska L, Centerbury J, Reiss E, Bricker NS (1972) On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using “proportional reduction” of dietary phosphorus intake. Kidney Int 2:147-151PubMedGoogle Scholar
  232. Slatopolsky E, Weerts C, Thielan J, Horst R, Harter H, Martin KJ (1984) Marked suppression of secondary hyperparathyroidism. J Clin Invest 74:2136-2143PubMedGoogle Scholar
  233. Slatopolsky E, Weerts C, Lopex-Hilkir S et al. (1986) Calcium carbonate as a phosphate binder in patients with chronic renal failure undergoing dialysis. N Engl J Med 315:157-161PubMedGoogle Scholar
  234. Slovik DM, Rosenthal DI, Doppelt SH, Potts JT Jr, Daly MA, Campbell JA, Neer RM (1986) Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1,25-dihydroxy vitamin D. J Bone Miner Res 1:377–381PubMedGoogle Scholar
  235. Smith DM, Khairi MRA, Johnston CC Jr (1975) The loss of bone mineral with ageing and its relationship to the risk of fracture. J Clin Invest 56:311-318PubMedGoogle Scholar
  236. Somerville PJ, Kaye M (1982) Action of phosphorus on calcium release in isolated perfused rat tails. Kidney Int 22:348-354PubMedGoogle Scholar
  237. Sowers MR, Wallace RB, Hollis BW (1990) The relationship of 1,25- dihydroxyvitamin D and radial bone mass. Bone Miner 10:139-148PubMedGoogle Scholar
  238. Spiegel AM (1989) Pseudohypoparathyroidism. In: Scriver CR et al. (eds) The metabolic basic of inherited disease. McGraw-Hill, New York, pp 2013–2027Google Scholar
  239. Stamp TCB, Walker PG, Perry W, Jenkins MV (1980) Nutrition osteomalacia and late rickets in Greater London 1974-1979. Clinical and metabolic studies in 45 patients. Clin Endocrinol Metab 9:81-105PubMedGoogle Scholar
  240. Stanbury SW (1972) Azotaemic renal osteodystrophy. Clin Endocrinol 1:267-304Google Scholar
  241. Stanbury SW, Lumb GA (1966) Parathyroid function in chronic renal failure. Q J Med 35:1-23PubMedGoogle Scholar
  242. Steinstrom G, Herdman PA (1974) Clinical findins in patients with hypercalcemia. Acta Med Scand 195:473-477Google Scholar
  243. Tada K, Yamamuro T, Okumura H, Kasai R, Takahashi H (1990) Restoration of axial and appendicular bone volumes by h-PTH (1-34) in parathyroidectomized and osteopenic rats. Bone 11:163-169PubMedGoogle Scholar
  244. Thakker RV, Bouloux P, Wooding C, Chotai K, Broad PM, Spurr NK, Besser GM, O’Riordan JLH (1989) Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11. N Engl J Med 321: 218-224PubMedGoogle Scholar
  245. Thompson NW, Eckhauser FE, Harness JK (1982) The anatomy of primary hyperparathyroidism. Surgery 92:814-824PubMedGoogle Scholar
  246. Tsai KS, Health H, Kumar R, Riggs BL (1984) Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis. J Clin Invest 73:1668-1672PubMedGoogle Scholar
  247. Vaishnava HP (1975) Vitamin D deficiency osteomalacia in Northern India. J Assoc Physicians India 23:477-484PubMedGoogle Scholar
  248. Wasnich RD, Ross PD, Heilbrun LK, Vogel JM (1985) Prediction of postmenopausal fracture risk with use of bone mineral measurements. Am J Obstet Gynecol 153:745-751PubMedGoogle Scholar
  249. Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3. J Clin Endocrinol Metab 67:373-378PubMedGoogle Scholar
  250. Webb AR, Pilbeam C, Hanafin N, Holick MF (1990) An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr 51:1075-1081PubMedGoogle Scholar
  251. Weiss A (1974) Incidence of subperiosteal resorption in hyperparathyroidism studied by fine detail bone radiography. Clin Radiol 25:273-276PubMedGoogle Scholar
  252. Whyte MP, Kim GS, Kosanovich M (1986) Absence of parathyroid tissue in sex- linked recessive hypoparathyroidism. J Pediatr 109:915PubMedGoogle Scholar
  253. Wiesner RH, Kumar R, Seeman E, Go VLH (1980) Enterohepatic physiology of 1,25 dihydroxy vitamin D metabolites in normal man. J Lab Clin Med 96: 1094-1100PubMedGoogle Scholar
  254. Wilson JD, Hadden DR (1980) Pseudohypoparathyroidism presenting with rickets. J Clin Endocrinol Metab 51:1184-1189PubMedGoogle Scholar
  255. Wilson RJ, Rao S, Ellis B, Kleerekoper M, Parfitt AM (1988b) Mild asymptomatic primary hyperparathyroidism is not a risk factor for vertebral fractures. Ann Intern Med 109:959-962PubMedGoogle Scholar
  256. Wilton TJ, Hosking DJ, Pawley E, Stevens A, Harvey L (1987) Osteomalacia and femoral neck fractures in the elderly patient. J Bone Joint Surg [Br] 69(3): 388-390Google Scholar
  257. Wiske PS, Epstein S, Bell NH, Queener SF, Edmondson J, Johnston CC Jr (1979) Increases in immunoreactive parathyroid hormone with age. N Engl J Med 300:1419-1421PubMedGoogle Scholar
  258. Yendt ER, Cohanim M, Jarzylo S, Jones G, Rosenberg G (1991) Bone mass is related to creatinine clearance in normal elderly women. J Bone Miner Res 6:1043-1050PubMedGoogle Scholar
  259. Young G, Marcus R, Minkogg JR, Kim LY, Segre GV (1987) Age-related rise in parathyroid hormone in man: the use of intact and midmolecule antisera to distinguish hormone secretion from retention. J Bone Miner Res 2:367–374PubMedGoogle Scholar

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