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Physiology and Pharmacology of Bone pp 443–483Cite as

Hyperparathyroid and Hypoparathyroid Bone Disease

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 107))

Abstract

Hyperparathyroid and hypoparathyroid diseases provide unique insights into the action of parathyroid hormone (PTH) on bone. Diseases of excess PTH arise either as a primary abnormality in hormone secretion, or as a compensatory response to a disorder of serum calcium homeostasis. Hypoparathyroidism usually arises from surgical removal of the parathyroids, although it may arise as an idiopathic disease. Uncommonly, the parathyroid receptor is defective, giving rise to increased PTH secretion but with failure of biological action.

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References

  • (1989) Recommended dietary allowances, 10th edn. National Academy Press, Washington

    Google Scholar 

  • (1991) Proceedings of the NIH Consensus Development Conference on diagnosis and management of asymptomatic primary hyperparathyroidism. Liebert, New York

    Google Scholar 

  • Aaron JE, Gallagher JC, Anderson J, Stasiak L, Longton EB, Nordin BEC, Nicholson M (1974) Frequency of osteomalacia and osteoporosis in fractures of the proximal femur. Lancet 1:229-233

    PubMed  CAS  Google Scholar 

  • Adams JS, Clemens TL, Parrish JA, Holick MF (1982) Vitamin D synthesis and metabolism after ultraviolet radiation of normal and vitamin D-deficient subjects. N Engl J Med 306:722-725

    PubMed  CAS  Google Scholar 

  • Ahn TG, Antonarakis SE, Kronenberg HM et al. (1986) Familial isolated hypopara- thyroidism: a molecular genetic analysis of 8 families with 23 affected persons. Medicine (Baltimore) 65:73-81

    CAS  Google Scholar 

  • Ahonen P (1985) Autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED): autosomal recessive inheritance. Clin Genet 27:535-542

    PubMed  CAS  Google Scholar 

  • Akerstrom G, Malmaeus J, Bergstrom R (1984) Surgical anatomy of human para- thyroid glands. Surgery 95:14-21

    PubMed  CAS  Google Scholar 

  • Akerstrom G, Rudberg C, Cyrimelius L et al. (1986) Histologic parathyroid adenoma and chief cell hyperphasia. Hum Pathol 17:520-527

    PubMed  CAS  Google Scholar 

  • Albright F, Reifenstein EC (1948) The parathyroid glands and metabolic bone disease. Williams and Wilkins, Baltimore

    Google Scholar 

  • Albright F, Forbes AP, Henneman PH (1952) Pseudopseudohypoparathyroidism. Trans Assoc Am Physicians 65:337

    PubMed  CAS  Google Scholar 

  • Anderson S, Meyer TW, Brenner BM (1987) Mechanisms of age-associated glomerular sclerosis. In: Cameron JS, Nunez JFM (eds) Renal function and disease in the elderly. Butterworth, London, pp 49-66

    Google Scholar 

  • Andress DL, Norris KC, Coburn JW, Slatopolsky EA, Sherrard DJ (1989) Intravenous calcitriol in the treatment of refactory osteitis fibrosa cystica of chronic renal failure. N Engl J Med 274-279

    Google Scholar 

  • Arnaud CD (1973) Hyperparathyroidism and renal failure. Kidney Int 4:89-95

    PubMed  CAS  Google Scholar 

  • Arnold A, Staunton CE, Kim HG, Gaz RD, Kronenberg HM (1988) Monoclonality and abnormal parathyroid hormone genes in parathyroid adenoma. N Engl J Med 318:658-662

    PubMed  CAS  Google Scholar 

  • Arnold A, Kim HG, Gaz RD, Eddy RL, Fukushima R, Byers MG, Shous TB, Kronenberg HM (1989) Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest 83:2034-2040

    PubMed  CAS  Google Scholar 

  • Arnold A, Horst SA, Gardella TJ, Baba H, Levine MA, Kronenberg HM (1990) Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism. J Clin Invest 86: 1084-1087

    PubMed  CAS  Google Scholar 

  • Attie MF, Gill JR Jr, Stock JL et al. (1983) Urinary calcium excretion in familial hypocalciuric hypercalcemia: persistence of relative hypocalcuria after induction of hypoparathyroidism. J Clin Invest 72:667-676

    PubMed  CAS  Google Scholar 

  • Baker LRI, Muir JW, Sharman VL, Abrams SML, Greenwood RN, Cattell WR, Goodwin FJ, Marsh FP, Adami S, Hately W, Hattersley LA, Morgan AG, Papapoulos SE, Revell PA, Tucker AK, Chaput de Saintonge DM, O’Riordan JLH (1986) Controlled trial of calcitriol in hemodialysis patients. Clin Nephrol 26(4): 185-191

    PubMed  CAS  Google Scholar 

  • Baker LRI, Abrams SML, Roe CJ, Faugere M-C, Fanti P, Subayti Y, Malluche HH (1989) l,25(OH)2D3 administration in moderate renal failure: a prospective double-blind trial. Kidney Int 35:661-669

    PubMed  CAS  Google Scholar 

  • Baker MR, McDonnell H, Peacock M, Nordin BEC (1979) Plasma 25-hydroxy vitamin D concentrations in patients with femoral fracture. Br Med J 1:589-591

    PubMed  CAS  Google Scholar 

  • Baker MR, Peacock M, Nordin BEC (1980) The decline of vitamin D status with age. Age Ageing 9:249-252

    PubMed  CAS  Google Scholar 

  • Bishop JM (1991) Molecular themes in oncogenesis. Cell 64:235-248

    PubMed  CAS  Google Scholar 

  • Block G, Dresser CM, Hartman AM, Carroll MD (1985) Nutrient sources in the American diet: quantitative data from the Hanes II survey. Am J Epidemiol 122:13-26

    PubMed  CAS  Google Scholar 

  • Bouillon RA, Auwerx JH, Lissens WD, Pelemans WK (1987) Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr 45:755-763

    PubMed  CAS  Google Scholar 

  • Breslau NA, Moses AM, Pak CY (1983) Evidence for bone remodeling but lack of calcium mobilization response to parathyroid hormone in pseudohypopara- thyroidism. J Clin Endocrinol Metab 57:638-644

    PubMed  CAS  Google Scholar 

  • Brezis M, Shaler O, Leibel B et al. (1982) The spectrum of parathyroid function in thalassaemia subjects with transfusional iron overload. Miner Electrolyte Metab 8:307

    PubMed  CAS  Google Scholar 

  • Brooks MH, Bell NH, Love L, Stern PH, Orfei E, Queener SF, Hamstra AJ, DeLuca HF (1978) Vitamin D-dependent rickets, type II resistance of target organs to 1,25-dihydroxy vitamin D. N Engl J Med 298:996-999

    PubMed  CAS  Google Scholar 

  • Buchanan JR, Myers CA, Greer RB (1988) Effect of declining renal function on bone density in aging women. Calcif Tissue Int 43:1-6

    PubMed  CAS  Google Scholar 

  • Burch WM, Posillico JT (1983) Hypoparathyroidism after 1-131 therapy with subsequent return of parathyroid function. J Clin Endocrinol Metab 57:398

    PubMed  CAS  Google Scholar 

  • Cann CE, Prussia SG, Gordon GS (1979) Aluminum uptake by the parathyroid glands. J Clin Endocrinol Metab 49:543-545

    PubMed  CAS  Google Scholar 

  • Carpenter TO, Carnes DL, Anast CS (1983) Hypoparathyroidism in Wilson’s disease. N Engl J Med 309:873

    PubMed  CAS  Google Scholar 

  • Castleman B, Kibble B (1963) Case records of the Massachusetts General Hospital. Case 29. N Engl J Med 268:943-953

    Google Scholar 

  • Chalmers J, Irvine GB (1988) Fractures of the femoral neck in elderly patients with hyperparathyroidism. Clin Orthop 125-130

    Google Scholar 

  • Chapman K (1971) Osteomalacia in Iran. J Obstet Gynaecol Br Commonw 78: 851-860

    Google Scholar 

  • Chapuy MC, Durr F, Chapuy P (1983) Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol levels. J Gerontol 38:19-22

    PubMed  CAS  Google Scholar 

  • Chapuy MC, Chapuy P, Meunier PJ (1987) Calcium and vitamin D supplements: effects on calcium metabolism in elderly people. Am J Clin Nutr 46:324-328

    PubMed  CAS  Google Scholar 

  • Charles P, Eriksen EF, Mosekilde L, Meisen F, Jensen FT (1987) Bone turnover and balance evaluated by a combined calcium balance and 47calcium kinetic study and dynamic histomorphometry. Metabolism 36:1118-1124

    PubMed  CAS  Google Scholar 

  • Christensson T, Hellstrom K, Wengle B, Alveryd A, Wiland B (1976) Prevalence of hypercalcemia in a health screening in Stockholm. Acta Med Scand 200:131-137

    PubMed  CAS  Google Scholar 

  • Christensson T, Hellstrom K, Wengle B (1977) Hypercalcemia and primary hyper- parathyroidism. Arch Intern Med 137:1138-1142

    PubMed  CAS  Google Scholar 

  • Clark OH, Wilkes W, Siperstein AE, Duh Q-Y (1991) Diagnosis and management of asymptomatic hyperparathyroidism: safety, efficacy, and deficiencies in our knowledge. J Bone Miner Res 6 Suppl 2:S135-S142

    Google Scholar 

  • Clemens T, Zhou X, Myles M, Endres D, Lindsay R (1986) Serum vitamin D2 and vitamin D3 metabolite concentrations and absorption of vitamin D2 in elderly subjects. J Clin Endocrinol Metab 63(3):656-660

    PubMed  CAS  Google Scholar 

  • Coburn JW, Hartenbower DL, Massry SG (1973) Intestinal absorption of calcium and the effect of renal insufficiency. Kidney Int 4:96-104

    PubMed  CAS  Google Scholar 

  • Cochran M, Platts MM, Moorhead PJ, Buxton H (1981) Spontaneous hypercalcaemia in maintenance dialysis patients: an association with a typical osteomalacia and fracture. Miner Electrolyte Metab 5:280-286

    Google Scholar 

  • Cohen J, Gierlowski TC, Schneider AB (1990) A prospective study of hyperpara- thyroidism in individuals exposed to radiation in childhood. JAMA 264:581-584

    PubMed  CAS  Google Scholar 

  • Compston JE, Ayers AB, Horon LWL, Tighe JR, Creamer B (1978a) Osteomalacia after small bowel resection. Lancet 1:9-12

    PubMed  CAS  Google Scholar 

  • Compston JE, Laker MF, Woodhead JS (1978b) Bone disease after jejuno-ileal bypass for obesity. Lancet 2:1-4

    PubMed  CAS  Google Scholar 

  • Corless D, Beer M, Boucher BJ, Gupta SP, Cohen RD (1975) Vitamin D status in long-stay geriatric patients. Lancet 1:1404-1406

    PubMed  CAS  Google Scholar 

  • Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, Mascioli SR, Scott JC, Seeley DG, Steiger P, Vogt TM (1990) Appendicular bone density and age predict hip fracture in women. JAMA 263:665-668

    PubMed  CAS  Google Scholar 

  • Dandona P, Menon RK, Shenoy R, Houlder S, Thomas M, Mallinson WJW (1986) Low 1,25-dihydroxyvitamin D, secondary hyperparathyroidism, and normal osteocalcin in elderly subjects. J Clin Endocrinol Metab 63(2):459-462

    PubMed  CAS  Google Scholar 

  • Dauphine RT, Riggs BL, Scholz DA (1975) Back pain and vertebral crush fractures: an unemphasized mode of presentation for primary hyperparathyroidism. Ann Intern Med 83:365-367

    PubMed  CAS  Google Scholar 

  • Davies DR, Dent CE, Willcox A (1956) Hyperparathyroidism and steatorthsea. Br Med J 2:1133-1137

    PubMed  CAS  Google Scholar 

  • Davies DR, Dent CE, Watson L (1968) Tertiary hyperparathyroidism. Br Med J 2:395-399

    Google Scholar 

  • Dawson-Hughes B (1991) Calcium supplementation and bone loss: a review of controlled clinical trials. Am J Clin Nutr 54 Suppl:274S-280S

    PubMed  CAS  Google Scholar 

  • Dawson-Hughes B, Jacques P, Shipp C (1987) Dietary calcium intake and bone loss from the spine in healthy postmenopausal women. Am J Clin Nutr 46:685-687

    PubMed  CAS  Google Scholar 

  • Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 323:878-883

    PubMed  CAS  Google Scholar 

  • Debnam JW, Bates ML, Kopelman RC, Teitelbaum SL (1977) Radiological/ pathological correlations in uremic bone disease. Diagn Radiol 125:653-658

    CAS  Google Scholar 

  • Deller DJ, Begley MD (1983) Calcium metabolism and the bones after partial gastrectomy. I. Clinical features and radiology of the bones. Australas Ann Med 12:282-294

    Google Scholar 

  • Delmas PD, Demlaux B, Malaval L et al. (1986) Serum bone gamma carboxy- lutamic acid containing protein in primary hyperparathyroidism and maligant hypercalcemia. Comparison with bone histomorphometry. J Clin Invest 77:985

    PubMed  CAS  Google Scholar 

  • Delmez JA, Tindira C, Grooms P, Dusso A, Windus DW, Slatopolsky E (1989) Parathyroid hormone suppression by intravenous 1,25dihydroxyvitamin D. J Clin Invest 83:1349-1355

    PubMed  CAS  Google Scholar 

  • Dent DM, Miller JL, Klatt L, Barron J (1987) The incidence and causes of hypercalcemia. Postgrad Med J 63:745-750

    PubMed  CAS  Google Scholar 

  • Dominquez JM, Mautalln CA, Rodo JE, Barcat JA, Molins ME (1970) Tertiary hyperparathyroidism diagnosed after renal homotransplantation. Am J Med 49:423-428

    Google Scholar 

  • Drezner MK, Nelson FA (1983) Pseudohypoparathyroidism. In: Stanbury JB (ed) The metabolic basis of inherited disease. McGraw-Hill, New York, p 1508

    Google Scholar 

  • Driscoll RH, Meredith SC, Wagonfeld JW, Rosenberg IH (1977) Bone histology and vitamin D status in Crohn’s disease. Assessment of vitamin D therapy. Gastroenterology 72:1051

    Google Scholar 

  • Drueke T (1980) Dialysis osteomalacia and aluminium intoxication. Nephron 26: 207-210

    PubMed  CAS  Google Scholar 

  • Duda RJ Jr, Kumar R, Nelson K, Zinsmeister AR, Mann KG, Riggs BL (1987) 1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women. J Clin Invest 79:1249-1253

    PubMed  Google Scholar 

  • Eastwood JB, Daly A, Carter GD, Alaghband-Zahek, DeWardener HE (1979) Plasma 25-hydroxy vitamin D in normal subjects and patients with terminal renal failure, on maintenance haemodialysis and after transplantation. Clin Sci 57:473

    PubMed  CAS  Google Scholar 

  • Eeckhout E, Verbeelen D, Sennesael J, Kaufman I, Jonckheer MH (1989) Monitoring of bone mineral content in patients on regular hemodialysis. Nephron 52:158-161

    PubMed  CAS  Google Scholar 

  • Ellis HA, Pierides AM, Feest TG, Ward MK, Kerr DNS (1977) Histopathology of renal osteodystrophy with particular reference to the effects of 1-hydroxy vitamin D3 in patients treated by long-term dialysis. Clin Endocrinol (Oxf) 7:31S-38S

    Google Scholar 

  • Epstein S, Bryce G, Hinman JW, Miller ON, Riggs BL, Hui SL, Johnston CC Jr (1986) The influence of age on bone mineral regulating hormones. Bone 7:421-425

    PubMed  CAS  Google Scholar 

  • Firth RG, Grant CS, Riggs BL (1985) Development of hypercalcemic hyperparathy- roidism after long-term phosphate supplementation in hypophosphatemic osteomalacia. Am J Med 78:669-673

    PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M (1987) Local action of oral 1,25-dihydroxycholecalciferol on calcium absorption in osteoporosis. Am J Clin Nutr 46:315-318

    PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M, Storer JH, Davies AEJ, Brown WB, Nordin BEC (1983) Calcium malabsorption in the elderly: the effect of treatment with oral 25 hydroxyvitamin D3. Eur J Clin Invest 13:391-396

    PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BEC (1984) Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci 66:103-107

    PubMed  CAS  Google Scholar 

  • Fraser DR, Kooh SW, Kind HP, Holick MF, Tanaka Y, DeLuca HF (1973) Pathogenesis of hereditary vitamin D dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1,25 dihydroxyvitamin D. N Engl J Med 289:817-822

    PubMed  CAS  Google Scholar 

  • Friedman E, Sakaguchhi K, Bale AE, Falchetti A, Streeten E, Zimering MB, Weinstein LS, McBride WD, Nakamura Y, Brandi M-L, Norton JA, Aurbach GD, Spiegel AM, Marx SJ (1989) Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med 321:213-218

    PubMed  CAS  Google Scholar 

  • Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF (1979) Intestinal calcium absorption and serum vitamin D. J Clin Invest 64:729-736

    PubMed  CAS  Google Scholar 

  • Gallagher JC, Melton LJ, Riggs BL, Bergstrath E, DeLuca HF (1980a) Epidemiology of fractures of the proximal femur in Rochester, Minnesota. Clin Orthop 150:163-171

    PubMed  Google Scholar 

  • Gallagher JC, Riggs BL, Jerpbak CM, Arnaud CD (1980b) The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women. J Lab Clin Med 95(3):373-385

    PubMed  CAS  Google Scholar 

  • Gardseil P, Johnell O, Nilsson BE (1989) Predicting fracture in women by using forearm bone densitometry. Calcif Tissue Int 44:235-242

    Google Scholar 

  • Genant HK, Heck LL, Lanzl LH, Rossman K, VanderHorst J, Paloyan E (1973) Primary hyperparathyroidism. Diagn Radiol 109:513-524

    CAS  Google Scholar 

  • Ghandur-Mnaymneh L, Kimura N (1984) The parathyroid adenoma: a histopath- ological definition with a study of 172 cases of primary hyperparathyroidism. Am J Pathol 115:70-83

    PubMed  CAS  Google Scholar 

  • Glorieux FH, Marie PJ, Pettifor JM, Delvin EE (1980) Bone response to phosphate salts, ergocalciferol and calcitriol in hypophosphatemie vitamin D-resistant rickets. N Engl J Med 303:1023-1031

    PubMed  CAS  Google Scholar 

  • Goodman WG, Henry DA, Horst R et al. (1984) Parenteral aluminium administra- tion in the dog: induction of osteomalacia and effect on vitamin D metabolism. Kidney Int 25:370-375

    PubMed  CAS  Google Scholar 

  • Graham K, Williams BO, Rowe MJ (1979) Idiopathic hypoparathyroidism: a cause of fits in the elderly. Br Med J 1:1460-1461

    PubMed  CAS  Google Scholar 

  • Gray RW, Wilz DR, Caldas AE, Lemann J (1977) The importance of phosphate in regulating plasma 1,25(OH)2 vitamin D levels in humans: studies in healthy subjects in calcium stone formers and patients with primary hyperparathyroidism. J Clin Endocrinol Metab 45:299-306

    PubMed  CAS  Google Scholar 

  • Greenfield BG (1990a) Hyperparathyroidism. In: Greenfield GB (ed) Radiology of bone diseases, 5th edn. Lippincott, Philadelphia, pp 43-61

    Google Scholar 

  • Greenfield GB (1990b) Renal osteodystrophy. In: Greenfield GB (ed) Radiology of bone diseases, 5th edn. Lippincott, Philadelphia, pp 62-73

    Google Scholar 

  • Greenfield GB (ed) (1990c) Radiology of bone diseases, 5th edn. Lippincott, Philadelphia

    Google Scholar 

  • Habener JF, Potts JT Jr (1990) Primary hyperparathyroidism. In: Avioli LV, Krane SM (eds) Metabolie bone disease. Saunders, Philadelphia, pp 475-545

    Google Scholar 

  • Hannon RR, Shorr E, McClellan WS, Dubois EF (1930) A case of osteites fibrosa cystica (osteomalacia?) with evidence of hyperactivity of the parathyroid bodies, metabolic study I. J Clin Invest 8:215-277

    PubMed  CAS  Google Scholar 

  • Haussier MR, McCain TA (1977) Vitamin D metabolism and action. N Engl J Med 297:974-983, 1041-1050

    Google Scholar 

  • Heath H III (1991) Clinical spectrum of primary hyperparathyroidism: evolution with changes in medical practice and technology. J Bone Miner Res 6 Suppl 2:S63-S70

    Google Scholar 

  • Heath H III, Hodgson SF, Kennedy MA (1980) Primary hyperparathyroidism: incidence, morbidity, and potential economic impact in a community. N Engl J Med 302(4): 189-193

    PubMed  Google Scholar 

  • Herbert LA, Lemann J, Petersen JR, Lennon EJ (1966) Studies of the mechanism by which phosphate infusion lowers serum calcium concentration. J Clin Invest 45:1886-1894

    CAS  Google Scholar 

  • Hercz G, Kraut JA, Andress DA et al. (1986) Use of calcium carbonate as a phosphate binder in dialysis patients. Mineral Electrolyte Metab 12:314-319

    CAS  Google Scholar 

  • Hesp R, Hulme P, Williams D, Reeve J (1981) The relationship between changes in femoral bone density and calcium balance in patients with involutional osteoporosis treated with human parathyroid hormone fragment (hPTH 1-34). Metab Bone Dis Relat Res 2:331-334

    Google Scholar 

  • Hock JM, Hummert JR, Boyce R, Fonseca J, Raisz LG (1989) Resorption is not essential for the stimulation of bone growth by hPTH-(1-34) in rats in vivo. J Bone Miner Res 4:449-458

    PubMed  CAS  Google Scholar 

  • Hodkinson HM, Round P, Stanton BR, Morgan C (1973) Sunlight, vitamin D and osteomalacia in the elderly. Lancet 1:910-912

    PubMed  CAS  Google Scholar 

  • Hodsman AB (1989) Effects of cyclical therapy of osteoporosis using an oral regimen of inorganic phosphate and sodium etidronate: a clinical and bone histomorphometric study. Bone Miner 5:201-212

    PubMed  CAS  Google Scholar 

  • Hodsman AB, Sherrard DJ, Alfrey AC et al. (1982) Bone aluminium and histomor- phometric features of renal osteodystrophy. J Clin Endocrinol Metab 54:539–546

    PubMed  CAS  Google Scholar 

  • Holick MF, Matsuoka LY, Wortsman J (1989) Age, vitamin D, and solar ultraviolet. Lancet 11

    Google Scholar 

  • Hordon LD, Peacock M (1987) Vitamin D metabolism in women with femoral neck fracture. Bone Miner 2:413-426

    PubMed  CAS  Google Scholar 

  • Hordon LD, Peacock M (1990) Osteomalacia and osteoporosis in femoral neck fracture. Bone Miner 11:247-259

    PubMed  CAS  Google Scholar 

  • Hori M, Uzawa T, Morita K, Noda T, Takahashi H, Inoue J (1988) Effect of human parathyroid hormone (PTH(l-34)) on experimental osteopenia of rats induced by ovariectomy. Bone Miner 3:193-199

    PubMed  CAS  Google Scholar 

  • Horsman A, Marshall DH, Peacock M (1985) A stochastic model of age-related bone loss and fractures. Clin Orthop 195:207-215

    PubMed  Google Scholar 

  • Hossain M, Smith DA, Nordin BEC (1970) Parathyroid activity and postmenopausal osteoporosis. Lancet 1:809-811

    PubMed  CAS  Google Scholar 

  • Hughes MR, Malloy PJ, O’Malley BW, Pike JW, Feldman D (1991) Genetic defects of the 1,25-dihydroxyvitamin D3 receptor. J Recept Res 11:699-716

    PubMed  CAS  Google Scholar 

  • Hui SL, Slemenda CW, Johnston CC Jr (1989) Baseline measurement of bone mass predicts fracture in white women. Ann Intern Med 111:355-361

    PubMed  CAS  Google Scholar 

  • Huvos AG (1991) Giant-cell tumor of bone. In: Huvos AG (ed) Bone tumors. Saunders, Philadelphia, pp 429-467

    Google Scholar 

  • Ireland P, Fordtran JS (1973) Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest 52:2672–2681

    PubMed  CAS  Google Scholar 

  • Jensen PS, Kliger AS (1977) Early radiographic manifestations by secondary hyper- parathyroidism associated with chronic renal disease. Diagn Radiol 125:645-652

    CAS  Google Scholar 

  • Joborn C, Rastad J, Stalberg E, Akerstrom G, Ljunghall S (1989) Muscle function in patients with primary hyperparathyroidism. Muscle Nerve 12:87-94

    PubMed  CAS  Google Scholar 

  • Johnston CC, Norton J, Khairi MR, Kernek C, Edouard C, Arlot M, Meunier PJ (1985) Heterogeneity of fracture syndromes in postmenopausal women. J Clin Endocrinol Metab 61:551–556

    PubMed  CAS  Google Scholar 

  • Johnston CC, Peacock M, Meunier P (1987) Osteomalacia as a risk factor for hip fractures in the U.S.A. In: Christiansen C, Johansen JS, Riis BJ (eds) Osteoporosis 1987. Norhaven, Viborg, pp 317-320

    Google Scholar 

  • Johnston CC, Melton LJ III, Lindsay R, Eddy DM (1989) Clinical indications for bone mass measurements. J Bone Miner Res 4:1-27

    Google Scholar 

  • Jung RT, Davie M, Hunter S, Chalmers TM (1978) Ultraviolet light: an effective treatment of osteomalacia in malabsorption. Br Med J 1:1668-1669

    PubMed  CAS  Google Scholar 

  • Kleeman CR, Massry SG, Coburn JW, Popovtzer MM (1969) Renal osteodystrophy, soft tissue calcification and disturbed divalent ion metabolism in chronic renal failure. Arch Intern Med 124:262

    PubMed  CAS  Google Scholar 

  • Kochersberger G, Buckley NJ, Leight GS, Martinez S, Studenski S, Volger J, Lyles KW (1987) What is the clinical significance of bone loss in primary hyperparathyroidism? Arch Intern Med 147:1951-1953

    PubMed  CAS  Google Scholar 

  • Kochersberger G, Westlund R, Lyles KW (1991) The metabolic effects of calcium supplementation in the elderly. J Am Geriatr Soc 39:192-196

    PubMed  CAS  Google Scholar 

  • Kokowicz MA, Melton J III, Cedel SL, O’Fallon WM, Riggs BL (1990) Effect of age on variables relating to calcium and phosphorus metabolism in women. J Bone Miner Res 5:345-352

    Google Scholar 

  • Krall EA, Sahyoun N, Tannenbaum S, Dallal GE, Dawson-Hughes B (1989) Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med 321:1777-1783

    PubMed  CAS  Google Scholar 

  • Kumar R (1984) Metabolism of 1,25-dihydroxy-vitamin D3. Physiol Rev 64:478–504

    PubMed  CAS  Google Scholar 

  • Labuda M, Morgan K, Glorieux FH (1990) Mapping autosomal recessive vitamin D dependency type I to chromosome 12q14 by linkage analysis. Am J Hum Genet 47:28-36

    PubMed  CAS  Google Scholar 

  • Lafferty FW (1991) Differential diagnosis of hypercalcemia. J Bone Miner Res 6 Suppl 2:S51-S59

    Google Scholar 

  • Lafferty FW, Hubay CA (1989) Primary hyperparathyroidism. A review of the long- term surgical and nonsurgical morbidities as a basis for a rational approach to treatment. Arch Intern Med 149:789-796

    PubMed  CAS  Google Scholar 

  • Larsson K, Lindh E, Lind L, Persson I, Ljunghall S (1989) Increased fracture risk in hypercalcemia. Bone mineral content measured in hyperparathyroidism. Acta Orthop Scand 60:268-270

    PubMed  CAS  Google Scholar 

  • Law WM Jr, Heath H (1985) Familial benign hypercalcemia (hypocalciuric hyper- calcemia). Clinical and pathogenetic studies in 21 families. Ann Intern Med 102:511-519

    PubMed  Google Scholar 

  • Law WM Jr, Carney JA, Health H III (1984) Parathyroid glands in familial benign hypercalcemia (hypocalciuric hypercalcemia). Am J Med 76:1021-1026

    PubMed  Google Scholar 

  • Lawoyin S, Sismilich S, Browne R, Pak CYC (1979) Bone mineral content in patients with calcium urolithiasis. Metabolism 28:1250-1254

    PubMed  CAS  Google Scholar 

  • Lawson DEM, Paul AA, Black AE, Cole TJ, Mandel AR, Davie M (1979) Relative contributions of diet and sunlight to vitamin D state in the elderly. Br Med J 1:303-305

    Google Scholar 

  • Leppla DC, Snyder W, Pak CY (1982) Sequential changes in bone density before and after parathyroidectomy in primary hyperparathyroidism. Invest Radiol 17:604-606

    PubMed  CAS  Google Scholar 

  • Levine MA, Aurbach GD (1989) Pseudohypoparathyroidism. In: DeGroot LJ (ed) Endocrinology. Saunders, Philadelphia, pp 1065-1079

    Google Scholar 

  • Liberman UA, Samuel R, Halabe A et al. (1980) End-organ resistance to 1,25 dihydroxycholecalciferol. Lancet 1:504-506

    PubMed  CAS  Google Scholar 

  • Lindergard B (1981) Changes in bone mineral content evaluated by photon absorptiometry before the start of active uremia treatment. Clin Nephrol 16:126-130

    PubMed  CAS  Google Scholar 

  • Lips P, Netelenbos JC, Jongen M, van Ginkel FC, Althuis AL, van Schaik CL, van der Vijgh WJF, Vermeider JPW, van der Meer C (1982) Histomorphometric profile and vitamin D status in patients with femoral neck fracture. Metab Bone Dis Relat Res 4(2):85-93

    PubMed  CAS  Google Scholar 

  • Lips P, Wiersinga A, van Ginkel FC, Jongen MJM, Netelenbos JC, Hackeng WHL, Delmas PD, van der Vighn WJF (1988) The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 67:644-650

    PubMed  CAS  Google Scholar 

  • Liu CC, Kalu DN (1990) Human parathyroid hormone-(1-34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats. J Bone Miner Res 5:973-982

    PubMed  CAS  Google Scholar 

  • Liu CC, Kalu DN, Salerno E, Echon R, Hollis BW, Ray M (1991) Preexisting bone loss associated with ovariectomy in rats is reversed by parathyroid hormone. J Bone Miner Res 6:1071-1080

    PubMed  CAS  Google Scholar 

  • Ljunghall S, Jakobsson S, Joborn C, Palmér M, Rastad J, Åkerström G (1991) Longitudinal studies of mild primary hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S111–S116

    Google Scholar 

  • MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536-1538

    PubMed  CAS  Google Scholar 

  • Malmaeus J, Granberg P-O, Halvosen J, Akerstrom G, Johannson H (1988) Parathyroid surgery in Scandinavia. Acta Chir Scand 154:409-413

    PubMed  CAS  Google Scholar 

  • Mandl F (1926) Klinisches und Experimentelles zur Frage der lokalisierten Ostitis fibrosa. B. Die generaliserte Form der Ostitis fibrosia. Arch Klin Chir 143:245

    Google Scholar 

  • Martin P, Bergmann P, Gillet C, Fuss M, Corvilain J, van Geertruyden J (1990) Long-term irreversibility of bone loss after surgery for primary hyper- parathyroidism. Arch Intern Med 150:1495-1497

    PubMed  CAS  Google Scholar 

  • Marx SJ (1991) Etiologies of parathyroid gland dysfunction in primary hyperpara- thyroidism. J Bone Miner Res 6 Suppl 2:S19-S24

    Google Scholar 

  • Massry SG, Stein R, Garty J et al. (1975) Skeletal resistance to the calcemic action of parathyroid hormone in uremia. Role of l,25(OH)2D3 (Abstr). Kidney Int 1:467-474

    Google Scholar 

  • Matloff DS, Kaplan MM, Neer RM et al. (1982) Osteoporosis in primary biliary cirrhosis: effects of 25-hydroxyvitamin D3 treatment. Gastroenterology 83:97-102

    PubMed  CAS  Google Scholar 

  • Mautalen C, Reyes HR, Ghiringhelli G, Fromm G (1986) Cortical mineral content in primary hyperparathyroidism. Changes after parathyroidectomy. Acta Endocrinol (Copenh) 111:494-497

    CAS  Google Scholar 

  • Mayer GP, Hurst JG (1878) Sigmoidal relationship between parathyroid hormone secretion rates and plasma calcium concentration in calves. Endocrinology 102: 1803-1807

    Google Scholar 

  • McKenna MJ, Freany R, Meade A, Muldowney FP (1985) Hypovitamin D and elevated serum alkaline phosphatase in elderly Irish people. Am J Clin Nutr 41:101

    PubMed  CAS  Google Scholar 

  • Melton LJ III (1991) Epidemiology of primary hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S25-S30

    PubMed  Google Scholar 

  • Memmos DE, Eastwood JB, Tarner B et al. (1982) Double-blind trial of oral 1,25- dihydroxy vitamin D3 versus placebo in asymptomatic hyperparathyroidism in patients receiving maintenance haemodialysis. Br Med J 282:1919-1924

    Google Scholar 

  • Meredith SC, Rosenberg IH (1980) Gastrointestinal hepatic disorders and oste- omalacia. Clin Endocrinol Metab 9:131-150

    PubMed  CAS  Google Scholar 

  • Miller JD, Bowker BM, Cole DEC et al. (1983) DeGeorge’s syndrome in monozygotic twins. Am J Dis Child 137:438-440

    PubMed  CAS  Google Scholar 

  • Mirra JM (1989) Brown tumor of hyperparathyroidism. In: Mirra JM (ed) Bone tumors. Lea and Febiger, Philadelphia, pp 1785-1799

    Google Scholar 

  • Morgan DB, Hunt G, Pasterson CR (1970) The osteomalacia syndrome after stomach operations. Q J Med 34:394-410

    Google Scholar 

  • Mundy GR, Core DH, Fisken R (1980) Primary hyperparathyroidism: changes in the pattern of clinical presentation. Lancet 1:1317–1321

    PubMed  CAS  Google Scholar 

  • Murray TM, Peacock M, Powell D, Manchik JM, Potts JT (1972) Non-autonomy of hormone secretion in primary hyperparathyroidism. Clin Endocrinol (Oxf) 1:235-246

    CAS  Google Scholar 

  • Neer RM, Slovik DM, Daly M, Lo C, Potts JT, Jr, Nussbaum SR (1990) Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol. In: Christiansen C, Overgaard K (eds) Osteoporosis 1990. Proceedings of the Third International Symposium on Osteoporosis. Osteopress, Copenhagen, pp 1314-1317

    Google Scholar 

  • Newton-John H, Morgan B (1970) The loss of bone with age: osteoporosis and fractures. Clin Orthop 71:229-252

    PubMed  CAS  Google Scholar 

  • Nordal KP, Dahl E (1988) Low dose calcitriol versus placebo in patients with predialysis chronic renal failure. J Clin Endocrinol Metab 67:929-936

    PubMed  CAS  Google Scholar 

  • Nordin BEC, Heaney RP (1990) Calcium supplementation of the diet: justified by present evidence. Br Med J 300:1056-1060

    CAS  Google Scholar 

  • Nordin BEC, Wilkinson R, Marshall DH, Gallagher JC, Williams A, Peacock M (1976) Calcium absorption in the elderly. Calc Tiss Res 21:442-451

    Google Scholar 

  • Nordin BEC, Peacock M, Aaron J, Crilly RG, Heyburn PJ, Horsman A, Marshall DH (1980) Osteoporosis and osteomalacia. Clin Endocrinol Metab 9:177-205

    PubMed  CAS  Google Scholar 

  • Nordin BEC, Baker MR, Horsman A, Peacock M (1985) A prospective trial of the effect of vitamin D supplementation on metacarpal bone loss in elderly women. Am J Clin Nutr 42:470-474

    PubMed  CAS  Google Scholar 

  • Nussbaum SR, Potts JT Jr (1991) Immunoassays for parathyroid hormone 1-84 in the diagnosis of hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S43-S50

    Google Scholar 

  • Nussbaum SR, Gaz RD, Arnold A (1990) Hypercalcemia and ectopic excretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone. N Engl J Med 323:1324-1328

    PubMed  CAS  Google Scholar 

  • Omdahl JL, Garry PJ, Hunsaker LA, Hunt WC, Goodwin JS (1982) Nutritional status in a healthy elderly population: vitamin D. Am J Clin Nutr 36:1225-1233

    PubMed  CAS  Google Scholar 

  • Orr-Walker B, Harris R, Holdaway IM, Foote G, Reid IR (1990) High per- ipheral and axial bone densities in a postmenopausal woman with untreated hypoparathyroidism. Postgrad Med J 66:1061-1063

    PubMed  CAS  Google Scholar 

  • Orwoll ES, Meier DE (1986) Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. J Clin Endocrinol Metab 63:1262-1269

    PubMed  CAS  Google Scholar 

  • Overton TR, Silverberg DS, Grace M et al. (1976) Bone demineralization in renal failure: a longitudinal study of the distal femur using photon absorptiometry. Br J Radiol 49:921-925

    PubMed  CAS  Google Scholar 

  • Pak CYC (1990) Kidney stones: pathogenesis, diagnosis and therapy. In: Avioli LV, Krane SM (eds) Metabolic bone disease. Saunders, Philadelphia, pp 823-849

    Google Scholar 

  • Pak CYC, Galosy RA (1979) Fasting urinary calcium and adenosive 3, 5 mono- phosphate: a discriminant analysis for the identification of renal absorptive hypercalcuria. J Clin Endocrinol Metab 48:260-265

    PubMed  CAS  Google Scholar 

  • Palmer M, Jakobsson G, Akerstrom G, Ljunghall S (1988) Prevalence of hyper- calcemia in a health survey: a 14-year-fellowship study of serum calcium values. Eur J Clin Invest 18:39-46

    PubMed  CAS  Google Scholar 

  • Parfitt AM (1977) Metacarpal cortical dimensions in hypoparathyroidism, primary hyperparathyroidism and chronic renal failure. Calcif Tissue Res Suppl. S329–S331

    Google Scholar 

  • Parfitt AM (1990) Osteomalacia and related disorders. In: Avioli LV, Krane SM (eds) Metabolic bone disease. Saunders, Jovanovich, Philadelphia, pp 329-396

    Google Scholar 

  • Parfitt AM, Miller MJ, Frame B, Villanueva AR, Rao DS, Oliver I, Thompson DL (1978) Metabolic bone disease after intestinal bypass for treatment of obesity. Ann Intern Med 89:193-199

    PubMed  CAS  Google Scholar 

  • Parfitt AM, Rao D, Stanciu J, Villanueva A, Kleerekoper M, Frame B (1985) Irreversible bone loss in osteomalacia. J Clin Invest 76:2403-2412

    PubMed  CAS  Google Scholar 

  • Parisien M, Silverberg SJ, Shane E, de La Cruz L, Lindsay R, Bilezikian JP, Dempster DW (1990) The histomorphometry of bone in primary hyperpara- thyroidism: preservation of cancellous bone structure. J Clin Endocrinol Metab 70:930-938

    PubMed  CAS  Google Scholar 

  • Parkinson IS, Ward MK, Feest TG et al. (1979) Fracturing dialysis osteodystrophy and dialysis encephalopathy: an epidemiological survey. Lancet 1:406-409

    PubMed  CAS  Google Scholar 

  • Peacock M, Robertson WG, Nordin BEC (1969) Relation between serum and urinary calcium with particular reference to parathyroid activity. Lancet 384–386

    Google Scholar 

  • Peacock M (1976) Parathyroid hormone and calcitonin. In: Nordin BEC (ed) Calcium, phosphate and magnesium metabolism. Churchill Livingstone, Edinburgh, pp 405-443

    Google Scholar 

  • Peacock M (1978) The endocrine control of calcium and phosphorus metabolism. Medicine (Baltimore) 9:407-417

    Google Scholar 

  • Peacock M (1980) Hypercalcaemia and calcium homeostasis. Metab Bone Dis Rel Res 2:143-150

    CAS  Google Scholar 

  • Peacock M (1984) Osteomalacia and rickets. In: Nordin BEC (ed) Metabolic bone and stone disease. Churchill Livingstone, Edinburgh, pp 71–111

    Google Scholar 

  • Peacock M (1991) Interpretation of bone mass determinations as they relate to fracture: implications for asymptomatic primary hyperparathyroidism. J Bone Miner Res 6 Suppl 2:S77-S82

    Google Scholar 

  • Peacock M, Hordon L (1989) Femoral fracture: the role of vitamin D. In: Kleerekoper M, Krane SM (eds) Clinical disorders of bone and mineral metabolism. Liebert, New York, pp 265-271

    Google Scholar 

  • Peacock M, Kradin RL (1981) A 76 year old women with intermittent hypercalcemia. Case records of the Massachusetts General Hospital. N Engl J Med 305: 1457-1464

    Google Scholar 

  • Peacock M, Robertson WG (1989) Urinary calcium stone disease. In: DeGroot LJ et al. (eds) Endocrinology. Saunders, Philadelphia, pp 1111-1132

    Google Scholar 

  • Peacock M, Aaron JE, Walker GS, Davison AM (1977a) Bone disease and hyper- parathyroidsm in chronic renal failure: the effect of 1 alpha hydroxy vitamin D3. Clin Endocrinol (Oxf) 7:73S-81S

    Google Scholar 

  • Peacock M, Heyburn PJ, Aaron JE et al. (1979) Osteomalacia: treated with 1- hydroxy or 1,25 dihydroxy vitamin D. In: Norman AW et al. (eds) Vitamin D, basic research and its clinical application. deGruyter, Berlin, pp 1177-1183

    Google Scholar 

  • Peacock M, Taylor GA, Brown W (1980) Plasma l,25(OH)2 D measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with primary hyperparathyroidism and renal failure. Clin Chim Acta 101:93-101

    PubMed  CAS  Google Scholar 

  • Peacock M, Bambach CP, Robertson WG, Aaron JE, Hill GL (1981) Urinary stone formation in bowel disease. In: Smith LH, Robertson WG, Finlayson B (eds) Urolithiasis: clinical and basic research. Plenum, New York, pp 159-168

    Google Scholar 

  • Peacock M, Horsman A, Aaron JE, Marshall DH, Selby PL, Simpson M (1984) The role of parathyroid hormone in bone loss. In: Christiansen et al. (ed) Osteo- porosis. Aalborg Stifsbogtrykkeri, Aalborg, pp 463-468

    Google Scholar 

  • Peacock M, Selby PL, Francis RM, Brown WB, Hordon L (1985) Vitamin D deficiency, insufficiency, sufficiency and intoxication. What do they mean? In: Normal AW, Schaefer K, Grigoleit H-G, Herrath DV (eds) Sixth workshop on vitamin D. de Gruyter, Berlin pp 569-570

    Google Scholar 

  • Pierides AM (1977) The role of phosphate in renal bone disease. Clin Endocrinol (Oxf) 7:101S-107S

    Google Scholar 

  • Pierides AM, Ellis HA, Simpson W et al. (1976) Variable response to long term 1- hydroxycholecalciferol in haemodialysis osteodystrophy. Lancet 1:1903-1095

    Google Scholar 

  • Pike JW (1991) Vitamin D3 receptors: structure and function in transcription. Annu Rev Nutr 11:189-216

    PubMed  CAS  Google Scholar 

  • Pipeleers-Marichal M, Somers G, Williams G et al. (1990) Gastrinomas in the duodenum of patients with multiple endocrine neoplasia type I and the Zollinger-Ellison syndrome. N Engl J Med 322:723-727

    PubMed  CAS  Google Scholar 

  • Piraino B, Chen T, Cooperstein L, Segre G, Puschett J (1988) Fractures and vertebral bone mineral density in patients with renal osteodystrophy. Clin Nephrol 30:57-62

    PubMed  CAS  Google Scholar 

  • Portale AA, Halloran BP, Murphy MM, Morris RC Jr (1986) Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxy vitamin D by determining its production rate in humans. J Clin Invest 77:7-12

    PubMed  CAS  Google Scholar 

  • Potts JT (1990) Management of asymptomatic hyperparathyroidism. J Clin Endocrinol Metab 70:1489-1493

    PubMed  Google Scholar 

  • Pugh DG (1951) Subperiosteal resorption of bone. A roentgenologic manifestation of primary hyperparathyroidism and renal osteodystrophy. AJR 66(4):577-586

    CAS  Google Scholar 

  • Rao DS (1985) Bone and mineral metabolism. In: Berk JE (ed) Bockus gastroenterology. Saunders, Philadelphia, pp 4629-4638

    Google Scholar 

  • Rao DS, Wilson RJ, Kleerekoper M, Parfitt AM (1988) Lack of biochemical progression or continuation of accelerated bone loss in mild asymptomatic primary hyperparathyroidism: evidence for biphasic disease course. J Clin Endocrinol Metab 67:1294-1298

    PubMed  CAS  Google Scholar 

  • Rasmussen H, Pechet M, Anast C, Mazur A, Gertner J, Broadus AE (1981) Long term treatment of familial hypophosphatemic rickets with oral phosphate and 1 alpha-hydroxy vitamin D3. J Pediatr 99:16-25

    PubMed  CAS  Google Scholar 

  • Rassmussen H, Bordier P, Marie P, Auquier L, Eisinger JB, Kuntz D et al. (1980) Effect of combined therapy with phosphate and calcitonin on bone volume in osteoporosis. Metab Bone Dis Relat Res 2:107-111

    Google Scholar 

  • Reeve J, Meunier PJ, Parsons JA, Bernat M, Bijvoet OLM, Courpron P, Edouard C, Klenerman L, Neer RM, Renier JC, Slovik D, Vismans FJFE, Potts JT Jr (1980) The anabolic effect of human parathyroid hormone fragment (hPTH 1- 34) therapy on trabecular bone in involutional osteoporosis: report of a multi- center trial. Br Med J 280:1340-1344

    PubMed  CAS  Google Scholar 

  • Reichel H, Koeffler HP, Norman AW (1989) The role of the vitamin D endocrine system in health and disease. N Engl J Med 320(15):980-991

    PubMed  CAS  Google Scholar 

  • Reiss E, Canterbury J, Egdahl RH (1968) Experience with a radioimmunoassay of parathyroid hormone in human sera. Trans Assoc Am Physiol 81:104-115

    CAS  Google Scholar 

  • Reiss E, Canterberry JM, Bercovile MA, Kaplan EL (1970) The role of phosphate in the secretion of parathyroid hormone in man. J Clin Invest 49:2146-2149

    PubMed  CAS  Google Scholar 

  • Richardson ML, Pozzi-Mucelli RS, Kanter AS, Kolb FO, Ettinger B, Genant HK (1986) Bone mineral changes in primary hyperparathyroidism. Skeletal Radiol 15:85-95

    PubMed  CAS  Google Scholar 

  • Rickers H, Christensen M, Rodbro P (1983) Bone mineral content in patients on prolonged maintenance hemodialysis: a three year follow-up study. Clin Nephrol 20:302-307

    PubMed  CAS  Google Scholar 

  • Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314:1676–1686

    PubMed  CAS  Google Scholar 

  • Riggs BL, Melton LJ III (1990) Clinical heterogeneity of involutional osteoporosis: implications for preventive therapy. J Clin Endocrinol Metab 70:1229-1232

    PubMed  CAS  Google Scholar 

  • Rosen JF, Fleischman AR, Fineberg L, Hamstra A, DeLuca HF (1979) Rickets with alopecia, an inborn error of vitamin D metabolism, J Pediatr 94:729-735

    PubMed  CAS  Google Scholar 

  • Rosen RA, Deshmukh SM (1985) Growth arrest recovery lines in hypoparathyroidism. Radiology 155:61-62

    PubMed  CAS  Google Scholar 

  • Ross PD, Davis JW, Vogel JM, Wasnich RD (1990) A critical review of bone mass and the risk of fractures in osteoporosis. Calcif Tissue Int 46:149-161

    PubMed  CAS  Google Scholar 

  • Roth SI (1971) Recent advances in parathyroid gland pathology. Am J Med 50: 612-622

    PubMed  CAS  Google Scholar 

  • Rutherford WE, Bordier P, Marie P, Hruska K, Harter H, Greenwalt A, Blondin J, Haddad J, Bricker N, Slatopolsky E (1977) Phosphate control and 25-hydroxycholecalciferol administration in preventing experimental renal osteodystrophy in the dog. J Clin Invest 60:332-341

    PubMed  CAS  Google Scholar 

  • Schantz A, Castleman B (1973) Parathyroid carcinoma: a study of 70 cases. Cancer 31:600-605

    PubMed  CAS  Google Scholar 

  • Seeman E, Wahner HW, Offord KP, Kumar R, Johnson WJ, Riggs BL (1982) Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest 69:1302-1309

    PubMed  CAS  Google Scholar 

  • Segre GV, Potts JT (1989) Differential diagnosis of hypercalcemia: methods and clinical applications of parathyroid assays. In: DeGroot LJ et al. (eds) Endocrinology. Saunders, Philadelphia, pp 984-1001

    Google Scholar 

  • Selby PL, Peacock M (1986) Ethinyl estradiol and norethindrone in the treatment of primary hyperparathyroidism in postmenopausal women. N Engl J Med 314: 1481-1485

    PubMed  CAS  Google Scholar 

  • Shakhall K, Nicar MJ, Brater DC et al. (1985) Exaggerated natriuretic and calciuric response to hydrochlorothiazide in renal hypercalcuria but not in absorptive hypercalcuria. J Clin Endocrinol Metab 61:825-829

    Google Scholar 

  • Sherman SS, Hollis BW, Tobin JD (1990) Vitamin D status and related parameters in a healthy population: the effects of age, sex and season. J Clin Endocrinol Metab 71:405-413

    PubMed  CAS  Google Scholar 

  • Sherrard DJ (1986) Renal osteodystrophy. Semin Nephrol 6:56-67

    PubMed  CAS  Google Scholar 

  • Shock NW (1987) The kidney: a model for the study of aging in a physiological system. In: Cameron JS, Nunez JFM (eds) Renal function and disease in the elderly. Butterworth, London, pp 1-2

    Google Scholar 

  • Shukla S, Gillespy T, Thomas WC Jr (1990) The effect of hypoparathyroidism on the aging skeleton. J Am Geriatr Soc 38:884-888

    PubMed  CAS  Google Scholar 

  • Silverberg SJ, Shane E, de La Cruz L, Dempster DW, Feldman F, Seldin D, Jacobs TP, Siris ES, Cafferty M, Parisien MV, Lindsay R, Clemens TL, Bilezikian JP (1989) Skeletal disease in primary hyperparathyroidism. J Bone Miner Res 4:283-291

    PubMed  CAS  Google Scholar 

  • Slatopolsky E, Coburn JW (1990) Renal osteodystrophy. In: Avioli LV, Krane SM (eds) Metabolic bone disease. Saunders, Philadelphia, pp 452-474

    Google Scholar 

  • Slatopolsky E, Caglar S, Gradowska L, Centerbury J, Reiss E, Bricker NS (1972) On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using “proportional reduction” of dietary phosphorus intake. Kidney Int 2:147-151

    PubMed  CAS  Google Scholar 

  • Slatopolsky E, Weerts C, Thielan J, Horst R, Harter H, Martin KJ (1984) Marked suppression of secondary hyperparathyroidism. J Clin Invest 74:2136-2143

    PubMed  CAS  Google Scholar 

  • Slatopolsky E, Weerts C, Lopex-Hilkir S et al. (1986) Calcium carbonate as a phosphate binder in patients with chronic renal failure undergoing dialysis. N Engl J Med 315:157-161

    PubMed  CAS  Google Scholar 

  • Slovik DM, Rosenthal DI, Doppelt SH, Potts JT Jr, Daly MA, Campbell JA, Neer RM (1986) Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1,25-dihydroxy vitamin D. J Bone Miner Res 1:377–381

    PubMed  CAS  Google Scholar 

  • Smith DM, Khairi MRA, Johnston CC Jr (1975) The loss of bone mineral with ageing and its relationship to the risk of fracture. J Clin Invest 56:311-318

    PubMed  CAS  Google Scholar 

  • Somerville PJ, Kaye M (1982) Action of phosphorus on calcium release in isolated perfused rat tails. Kidney Int 22:348-354

    PubMed  CAS  Google Scholar 

  • Sowers MR, Wallace RB, Hollis BW (1990) The relationship of 1,25- dihydroxyvitamin D and radial bone mass. Bone Miner 10:139-148

    PubMed  CAS  Google Scholar 

  • Spiegel AM (1989) Pseudohypoparathyroidism. In: Scriver CR et al. (eds) The metabolic basic of inherited disease. McGraw-Hill, New York, pp 2013–2027

    Google Scholar 

  • Stamp TCB, Walker PG, Perry W, Jenkins MV (1980) Nutrition osteomalacia and late rickets in Greater London 1974-1979. Clinical and metabolic studies in 45 patients. Clin Endocrinol Metab 9:81-105

    PubMed  CAS  Google Scholar 

  • Stanbury SW (1972) Azotaemic renal osteodystrophy. Clin Endocrinol 1:267-304

    Google Scholar 

  • Stanbury SW, Lumb GA (1966) Parathyroid function in chronic renal failure. Q J Med 35:1-23

    PubMed  CAS  Google Scholar 

  • Steinstrom G, Herdman PA (1974) Clinical findins in patients with hypercalcemia. Acta Med Scand 195:473-477

    Google Scholar 

  • Tada K, Yamamuro T, Okumura H, Kasai R, Takahashi H (1990) Restoration of axial and appendicular bone volumes by h-PTH (1-34) in parathyroidectomized and osteopenic rats. Bone 11:163-169

    PubMed  CAS  Google Scholar 

  • Thakker RV, Bouloux P, Wooding C, Chotai K, Broad PM, Spurr NK, Besser GM, O’Riordan JLH (1989) Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11. N Engl J Med 321: 218-224

    PubMed  CAS  Google Scholar 

  • Thompson NW, Eckhauser FE, Harness JK (1982) The anatomy of primary hyperparathyroidism. Surgery 92:814-824

    PubMed  CAS  Google Scholar 

  • Tsai KS, Health H, Kumar R, Riggs BL (1984) Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis. J Clin Invest 73:1668-1672

    PubMed  CAS  Google Scholar 

  • Vaishnava HP (1975) Vitamin D deficiency osteomalacia in Northern India. J Assoc Physicians India 23:477-484

    PubMed  CAS  Google Scholar 

  • Wasnich RD, Ross PD, Heilbrun LK, Vogel JM (1985) Prediction of postmenopausal fracture risk with use of bone mineral measurements. Am J Obstet Gynecol 153:745-751

    PubMed  CAS  Google Scholar 

  • Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3. J Clin Endocrinol Metab 67:373-378

    PubMed  CAS  Google Scholar 

  • Webb AR, Pilbeam C, Hanafin N, Holick MF (1990) An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr 51:1075-1081

    PubMed  CAS  Google Scholar 

  • Weiss A (1974) Incidence of subperiosteal resorption in hyperparathyroidism studied by fine detail bone radiography. Clin Radiol 25:273-276

    PubMed  CAS  Google Scholar 

  • Whyte MP, Kim GS, Kosanovich M (1986) Absence of parathyroid tissue in sex- linked recessive hypoparathyroidism. J Pediatr 109:915

    PubMed  CAS  Google Scholar 

  • Wiesner RH, Kumar R, Seeman E, Go VLH (1980) Enterohepatic physiology of 1,25 dihydroxy vitamin D metabolites in normal man. J Lab Clin Med 96: 1094-1100

    PubMed  CAS  Google Scholar 

  • Wilson JD, Hadden DR (1980) Pseudohypoparathyroidism presenting with rickets. J Clin Endocrinol Metab 51:1184-1189

    PubMed  CAS  Google Scholar 

  • Wilson RJ, Rao S, Ellis B, Kleerekoper M, Parfitt AM (1988b) Mild asymptomatic primary hyperparathyroidism is not a risk factor for vertebral fractures. Ann Intern Med 109:959-962

    PubMed  CAS  Google Scholar 

  • Wilton TJ, Hosking DJ, Pawley E, Stevens A, Harvey L (1987) Osteomalacia and femoral neck fractures in the elderly patient. J Bone Joint Surg [Br] 69(3): 388-390

    CAS  Google Scholar 

  • Wiske PS, Epstein S, Bell NH, Queener SF, Edmondson J, Johnston CC Jr (1979) Increases in immunoreactive parathyroid hormone with age. N Engl J Med 300:1419-1421

    PubMed  CAS  Google Scholar 

  • Yendt ER, Cohanim M, Jarzylo S, Jones G, Rosenberg G (1991) Bone mass is related to creatinine clearance in normal elderly women. J Bone Miner Res 6:1043-1050

    PubMed  CAS  Google Scholar 

  • Young G, Marcus R, Minkogg JR, Kim LY, Segre GV (1987) Age-related rise in parathyroid hormone in man: the use of intact and midmolecule antisera to distinguish hormone secretion from retention. J Bone Miner Res 2:367–374

    PubMed  CAS  Google Scholar 

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Peacock, M. (1993). Hyperparathyroid and Hypoparathyroid Bone Disease. In: Physiology and Pharmacology of Bone. Handbook of Experimental Pharmacology, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77991-6_13

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