The liver is a relatively radiosensitive organ. The radiation sensitivity of the liver is to a great extent related to radiation damage of small blood vessels in the liver. Biopsies performed within 2 months after irradiation to dose levels between 30–60 Gy show sinusoidal congestion, hyperemia, loss of central hepatic cells, and vascular changes including loss of endothelium and thickening of intima. Two to four months after irradiation, obliterative changes in efferent veins with collagenous tissue in the lumen are found. After 4 months the specimens reveal fatty vacuolization, vascular changes, centrilobular fibrosis, and atrophy.


Liver Metastasis Transcatheter Arterial Embolization Glass Microsphere Radioactive Seed Intraarterial Injection 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Henri-Marcel Hoogewoud
    • 1
  1. 1.Cantonal HospitalFribourgSwitzerland

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