Zusammenfassung
Warum brauchen wir eigentlich neue intravenöse Hypnotika wie S(+)-Ketamin, Midazolam, Etomidat oder Propofol?
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Literatur
Bell GD, Spickett GP, Reeve PA, Morden A, Logan RF (1987) Intravenous midazolam for upper gastrointestinal endoscopy. A study of 800 consecutive cases relating dose to age and sex of patients. Br J Clin Pharmacol 23: 241–243
Burch PG, Stanski DR (1983) The role of metabolism and protein binding in thiopental anesthesia. Anesthesiology 58: 146–152
Hudson RJ, Stanski DR, Burch PG (1983) Pharmacokinetics of methohexital and thiopental in surgical patients. Anesthesiology 59: 215–219
Klotz U. Avant GR, Hoyumpa A, Schenker S,Wilkinson GR (1975) The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J clin Invest 55: 347–359
Kugler J, Doenicke A, Laub M (1977) The EEG after etomidate. In: Doenicke A (Hrsg) Etomidate an intravenous hypnotic agent. Springer, Berlin Heidelberg New York (Anaesthesiologie und Wiederbelebung, Bd 106, S 31–48 )
Lauven PM (1992) Besonderheiten der anästhesiologischen Arzneimitteltherapie. In: Schüttler J, Schwilden H, Lauven PM (Hrsg) Klinische Pharmakologie und rationale Arzneimitteltherapie. Symposium in Bonn. Thieme, Stuttgart New York, (INA 80: 52–61 )
Lauven PM, Schwilden H, Stoeckel 1987 ) Hypnotic threshold concentrations of metho- hexitone. Eur J Clin Pharmacol 33: 261–265
Lauven PM, Stoeckel H (1987) Hypnotisch wirksame Blutspiegel von Midazolam. Anästh. Intensivther. Notfallmed 22: 90–93
Lauven PM, Stoeckel H, Schwilden H, Schüttler J (1981) Klinische Pharmakokinetik von Midazolam, Flunitrazepam und Diazepam. Anästh. Intensivther. Notfallmed 16: 135–142
Lauven PM, Stoeckel H, Ochs H, Greenblatt DJ (1981) Pharmakokinetische Untersuchungen mit dem neuen Benzodiazepin Midazolam. Anaesthesist 30: 280–283
Lundy JS (1936) Intravenous anesthesia. Am J Surg 34: 559–570
Persson MP, Nilsson A, Hartvig (1988) Relation of sedation and amnesia to plasma concentrations of midazolam in surgical patients. Clin Pharmacol Ther 32: 324–331
Schüttler (1990) Pharmakokinetik und -dynamik des intravenösen Anaesthetikums Profol (Disoprivan). Grundlagen für eine optimierte Dosierung. Springer, Berlin Heidelberg New York Tokyo ( Anaesthesiologie und Intensivmedizin, Bd 202 )
Schüttler J, Schwilden H, Stoeckel H (1985) Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: Etomidate as an example. Eur J Anaesth 2: 133–142
Schüttler J, Stanski DR, White PF, Trevor AJ, Horai Y,Verotta DV, Sheiner LB (1987) Pharmacodynamic modelling of the EEG effects of ketamine and its enantiomers in man. J Pharmacokin Biopharm 15: 241–253
Schüttler J, Wilms M, Lauven PM, Stoeckel H, Koenig A (1981) Pharmakokinetische Untersuchungen über Etomidat beim Menschen. Anaesthesist 29: 658–661
Schwilden H, Stoeckel H (1980) Untersuchungen über verschiedene EEG-Parameter als Indikatoren des Narkosezustandes. Der Median als quantitatives Maß der Narkosetiefe. Anästh. Intensivther. Notfallmed 15: 279–286
Schwilden H, Stoeckel H, Schüttler J, Lauven PM (1986) Pharmacological models and their use in clinical anaesthesia. Eur J Anaesth 3: 175–208
Short TG, Chui PT (1991) Propofol and midazolam act synergistically in combination. Br J Anaesth 67: 539–545
Tverskoy M, Ben-Shlomo I, Ezry J, Finger J, Fleyshman G (1989) Midazolam acts synergistically with methohexitone for induction of anaesthesia. Br J Anaesth 63: 109–112
Vinik HR, Bradley EL, Kissin J (1989) Midazolam- alfentanil synergism for anesthetic induction in patients. Anesth Analg 69: 213–217
White PF, Ham J,Way WL,Trevor AJ (1980) Pharmacology of ketamine isomers in surgical patients. Anesthesiology 52: 231–239
White PF, Schüttler J, Shafer A, Stnski DR, Horai Y, Trevor AJ (1985) Comparative pharmacology of the ketamine isomers. Studies in volunteers. Br J Anaesth 57: 197–203
White PF, Vasconez LO, Mathes (1988) Comparison of midazolam and diazepam for sedation during plastic surgery. J Plast Reconstr Surg 81: 703–706
Wieber J, Gugler R, Hengstmann HJ, Dengler HJ (1975) Pharmacokinetics of ketamine in man. Anesthesist 24: 260–263
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Lauven, P.M., Schüttler, J. (1993). Pharmakodynamik und Pharmakokinetik neuerer intravenöser Hypnotika (Etomidat, Midazolam, Propofol, S-Ketamin). In: Dick, W., Eberle, B., Gervais, H., Heinrichs, W., Klein, A. (eds) Totale intravenöse Anästhesie (TIVA). Klinische Anästhesiologie und Intensivtherapie, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77966-4_1
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DOI: https://doi.org/10.1007/978-3-642-77966-4_1
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