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Structure of the TFIIIA-DNA Complex

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Book cover Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 7))

Abstract

Our current understanding of the expression of eukaryotic class III genes has benefited greatly from studies of the developmentally regulated 5S RNA gene system of the African clawed frog Xenopus (Wolffe and Brown 1988). In addition, how the 5S-specific transcription factor III A (TFIIIA) interacts with 5S DNA has proven to be a most interesting problem in structural biology. The elucidation of the primary structure of TFIIIA led to the recognition of a whole new class of DNA-binding proteins, those containing the zinc finger, of which TFIIIA is the prototypical example (Miller et al. 1985). Moreover, the unusual way in which this protein binds to DNA has sparked the development of new solution-based techniques for understanding the structure of this and other protein-DNA complexes (Shastry 1991; Hayes and Tullius 1992).

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Author information

Authors and Affiliations

  1. National Institute of Child Health and Development, National Institutes of Health, Building 6, Room B-1A09, Bethesda, Maryland, 20892, USA

    J. J. Hayes

  2. Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA

    T. D. Tullius

Authors
  1. J. J. Hayes
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  2. T. D. Tullius
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, DD1 4HN, Dundee, UK

    David M. J. Lilley

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© 1993 Springer-Verlag Berlin Heidelberg

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Hayes, J.J., Tullius, T.D. (1993). Structure of the TFIIIA-DNA Complex. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77950-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-77950-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77952-7

  • Online ISBN: 978-3-642-77950-3

  • eBook Packages: Springer Book Archive

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