The Role of the Nucleoskeleton in RNA Metabolism

  • P. R. Cook
  • A. Dolle
  • A. B. Hassan
  • P. Hozak
  • D. A. Jackson
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 7)


The level of expression of the rat growth hormone gene in liver tumour cells is at least eight orders of magnitude less than that in anterior pituitary cells (Ivarie et al. 1983). This is to be compared with a 100-fold reduction in expression obtained by deleting promoters, enhancers or transcription-factor binding sites in plasmids prior to their transfection into tissue culture cells (Muller et al. 1988). Clearly, other important mechanisms must be superimposed upon the ones involving transcription factors that we know so much about. This essay will explore recent evidence that points to higher-order gene structure as a key determinant of activity.


Anterior Pituitary Cell Transcription Complex Nascent Transcript Liver Tumour Cell Polymerization Site 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. R. Cook
  • A. Dolle
  • A. B. Hassan
  • P. Hozak
  • D. A. Jackson
    • 1
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

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