Pathogenetische Bedeutung der intestinalen Bakterienflora für die Entwicklung chronischer intrahepatischer Cholangitiden

  • U. Hopf
  • R. Stemerowicz
  • V. König
  • S. Küther
  • H. Lobeck
  • K. Miksits
  • J. Wagner
Conference paper

Zusammenfassung

Enterale Mikroorganismen oder deren Komponenten können durch Aszension in den Gallenwegen, auf lymphogenem Wege oder auf dem Blutwege über die Pfortader bzw. systemische Zirkulation zur Leber gelangen und in unterschiedlicher Weise mit der Leber interagieren. Die intrahepatischen Folgen richten sich nach den biologischen Aktivitäten und der Konzentration der Erreger bzw. der Erregerkomponenten. So wird man hinsichtlich der hepatologischen Bedeutung enteraler Mikroorganismen vor allem 3 Aspekte berücksichtigen müssen: die Leber als Zielorgan von Infektionserregern, die Leber als Clearanceorgan mit metabolischen und detoxifizierenden Funktionen und schließlich die Leber als immunologisches Organ mit der Synthese abwehraktiver Mediatoren.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • U. Hopf
  • R. Stemerowicz
  • V. König
  • S. Küther
  • H. Lobeck
  • K. Miksits
  • J. Wagner

There are no affiliations available

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