Nahrung und Karzinogenese

  • R. Voigtmann
Conference paper


Vor genau 50 Jahren beschrieb Tannenbaum [9] in seiner in Cancer Research publizierten Pionierarbeit erstmals die Bedeutung fettreicher Ernährung für die Inzidenz verschiedener Tumoren, insbesondere der Dickdarmkarzinome.


  1. 1.
    Baker SJ, Fearon ER, Nigro JM (1990) Chromosom 17 deletions and p 53 gene mutations in colorectal carcinomas. Science 244: 217–221CrossRefGoogle Scholar
  2. 2.
    Bristol JB, Emmet PM, Heaton KW, Williamson RCN (1985) Sugar, fat and the risk of colorectal cancer. Br Med J 291: 1467–1470CrossRefGoogle Scholar
  3. 3.
    Delattre P, Olschwang S, Law DJ (1990) Multiple genetic alterations distinguish distal from proximal colorectal cancer. Lancet IL•353–356Google Scholar
  4. 4.
    Doll FRS, Peto R (1981) The causes of cancer. Oxford Univ. Press New YorkGoogle Scholar
  5. 5.
    Fearon ER, Cho KR, Nigro JM (1990) Identification of a chromosom 18 q gene that is altered in colorectal cancers. Science 247: 49–56PubMedCrossRefGoogle Scholar
  6. 6.
    Guillem JG, Levy MF, Hsieh L-L, Johnson MD, LoGerfo P, Forde KA, Weinstein IB (1990) Increased levels of phorbin, C-myc and ornithine decarboxylase in human colon cancer. Mol Carcinog 3: 68–74PubMedCrossRefGoogle Scholar
  7. 7.
    Haenszel W, Kurihara M (1968) Studies of Japanese emigrants. I. Mortality from cancer arid other diseases among Japanese in the United States. J Nat Cancer Inst 40: 43–68PubMedGoogle Scholar
  8. 8.
    Morotomi M, Guillem JG, LoGerfo P., Weinstein IB (1990) Production of diacylglycerol, an activator of protein-kinase C, by human intestinal microflora. Cancer Res 50: 3595–3599PubMedGoogle Scholar
  9. 9.
    Tannenbaum A (1942) The genesis of growth of tumors: III. Effect of high-fat diet. Cancer Res 2: 468–493Google Scholar
  10. 10.
    Tuyns AJ, Haeltermann M, Kaaks R (1987) Colorectal cancer and the intake of nutrients: Oligosacharides are a risk factor, fats are not: a case-control study in Belgium. Nutr Cancer 10: 181–196PubMedCrossRefGoogle Scholar
  11. 11.
    Vogelstein B, Fearon ER, Hamilton SR et al. (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525–532PubMedCrossRefGoogle Scholar
  12. 12.
    Weinberg RA (1989) Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res 49: 3713–3721PubMedGoogle Scholar
  13. 13.
    Weinstein IB (1991) Cancer prevention: recent progress and future opportunities. Cancer Res (Suppl) 51: 5080–5085Google Scholar
  14. 14.
    Willet WC (1989) The search for the causes of breast and colon cancer. Nature 338: 389–394CrossRefGoogle Scholar
  15. 15.
    Willet WC, Stampfer MJ, Coldlitz GA, Rosner BA, Speizer FE (1990) Relation of meat, fat and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med 323: 1646–1672CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

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  • R. Voigtmann

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