Skip to main content

Molekulargenetische Aspekte der Basalimentstehung

  • Chapter
Das Basaliom
  • 24 Accesses

Zusammenfassung

Chronische Exposition mit ultravioletter Strahlung ist der wichtigste Risiko faktor für die Basaliomentstehung. Klinische und epidemiologische Untersuchungen zeigen einen eindeutigen Zusammenhang zwischen der kumulativen UV-Gesamtdosis und der Entwicklung von Basaliomen. Daneben spielen Arsenexposition, ionisierende Strahlen und chronische Hautschädigung als Risikofaktoren nur eine untergeordnete Bedeutung. Dabei ist der Zusammenhang zwischen UV-Strahlung und Tumorgenese allerdings nicht so eindeutig wie z. B. beim Spinaliom. Nicht selten treten Basaliome auch in nur relativ gering photogeschädigter Haut auf.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Alcalay J, Freeman SE, Goldberg LH, Kripke ML, Wolf JE (1990) Decreased excision repair of pyrimidine dimers induced in skin of basal cell carcinoma patients by simulated solar radiation. J Invest Derm 94, p 502 (Abstract)

    Google Scholar 

  • Bale AE, Bale SJ, Murli H, Ivett J, Mullvihill JJ, Parry DM (1989) Sister chromatid exchange and chromosome fragility in the nevoid basal cell carcinoma syndrome. Cancer Genet Cytogenet 42:273–279

    Article  PubMed  CAS  Google Scholar 

  • Ben-Ishai R, Scharf R, Sharon R, Kapten I (1990) A human cellular sequence implicated in trk oncogene activation is DNA damage inducible. Proc Natl Acad Sci USA 87:6039–6043

    Article  PubMed  CAS  Google Scholar 

  • Czarnecki D, Lewis A, Nicholson I, Tait B (1991) Multiple basal cell carcinomas and HLA frequencies in southern Australia. J Am Acad Derm 24:559–561

    Article  PubMed  CAS  Google Scholar 

  • Chan GL, Little JB (1983) Cultured diploid fíbroblasts from patients with the nevoid basal cell carcinoma syndrome are hypersensitive to killing by ionizing radiation. Am J Path 111, p 497

    Google Scholar 

  • Consensus Development Panel (1991) National Institutes of Health Summary of the Consensus Development Conference on Sunlight, Ultraviolet Radiation, and the skin, Bethesda Maryland, May 8–10. J Am Acad Derm 24:608-612

    Article  Google Scholar 

  • Patterson M, Chu G (1989) Evidence that xeroderma pigmentosum cells from complementation group E are deficient in a homolog of yeast photolyase. Mol Cell Biol 9:5105–5112

    PubMed  CAS  Google Scholar 

  • Rünger TM, Kraemer KH (1989) Joining of linear plasmid DNA is reduced and errorprone in Bloom’s syndrome cells. EMBO 8:1419–1425

    Google Scholar 

  • Weeda G, van Ham RC, Vermeulen W, Bootsma D, van der Eb AJ, Hoeijmakers JH (1990) A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockeyne’s syndrome. Cell 62:777–791

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rünger, T.M. (1993). Molekulargenetische Aspekte der Basalimentstehung. In: Petres, J., Lohrisch, I. (eds) Das Basaliom. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77908-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77908-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77909-1

  • Online ISBN: 978-3-642-77908-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics