Hexamethypropylene Amine Oxime Single-Photon Emission-Computed Tomography in Perinatal Asphyxia and Ischemic—Hemorrhagic Lesions
Perinatal asphyxia is a principal recognized cause of perinatal death and abnormal neurodevelopmental outcome in both mature and preterm neonates. Ischemia and hemorrhage are the main components of central nervous system (CNS) injuries following perinatal asphyxia. The initiating stimulus which leads to lesions is a lack of cerebral blood flow (CBF) autoregulation (Volpe 1987; Lou et al. 1979a). Besides conventional brain imaging, such as ultrasound (US), magnetic resonance imaging (MRI), or computed tomography (CT) scan, the assessment of cerebral hemodynamics seems to be interesting since CBF impairment constitutes the background of ischemia and hemorrhage. In the last few years, increasing interest has been focused on techniques using radionuclides to image and measure CBF. Among them, single photon emission computed tomography (SPECT) is far less expensive and not as complicated as the others (e.g., positron emission tomography-PET scan). Moreover, it has proven to be useful in evaluating cerebral perfusion (CP) or regional cerebral blood flow (rCBF) in adults and children (Hellman et al. 1990; Uvebrant et al. 1991). In neonates, few data are available (Denays et al. 1989; Haddad et al. 1991). In this chapter, we will give an overview of the use of SPECT based on our experience. At the moment we are investigating more than 45 neonates using this technique, mainly for anoxic-ischemic brain injuries.
KeywordsIschemia Lactate Glutathione Germinal Syringe
Unable to display preview. Download preview PDF.
- Denays R, van Pach Terbke T, Tondeur M, Spehl M, Toppet V, Ham H, Piepz A, Rubinstein M, Noel P, Haumon D (1989) Brain single-photon emission-computed tomography in neonates. J Nucl Med 30:1338–1341Google Scholar
- Haddad J, Constantinesco A, Brunot B (1991) SPECT of the brain perfusion in neonates. In: Haddad J, Christmann D, Messer J (eds) Imaging techniques of the neonate. Springer, Berlin Heidelberg New York, pp 171–182Google Scholar
- Messer J (1991) Cerebral Doppler in neonates. In: Haddad J, Christmann D, Messer J (eds) Imaging techniques of the neonates. Springer, Berlin Heidelberg New York, pp 107–116Google Scholar
- Tyrell DA (1985) Amersham report N109/28: European phase I and II. Clinical trials UvebrantGoogle Scholar
- Vanucci RC (1978) Neurologic aspects of perinatal asphyxia. Pediatr Ann 7:15–30Google Scholar
- Volpe JJ (1987) Neurology of the newborn. Saunders, Philadelphia, pp 209–233Google Scholar