Hexamethypropylene Amine Oxime Single-Photon Emission-Computed Tomography in Perinatal Asphyxia and Ischemic—Hemorrhagic Lesions

  • J. Haddad
  • A. Constantinesco
  • A. Facello
  • B. Brunot
  • J. Messer


Perinatal asphyxia is a principal recognized cause of perinatal death and abnormal neurodevelopmental outcome in both mature and preterm neonates. Ischemia and hemorrhage are the main components of central nervous system (CNS) injuries following perinatal asphyxia. The initiating stimulus which leads to lesions is a lack of cerebral blood flow (CBF) autoregulation (Volpe 1987; Lou et al. 1979a). Besides conventional brain imaging, such as ultrasound (US), magnetic resonance imaging (MRI), or computed tomography (CT) scan, the assessment of cerebral hemodynamics seems to be interesting since CBF impairment constitutes the background of ischemia and hemorrhage. In the last few years, increasing interest has been focused on techniques using radionuclides to image and measure CBF. Among them, single photon emission computed tomography (SPECT) is far less expensive and not as complicated as the others (e.g., positron emission tomography-PET scan). Moreover, it has proven to be useful in evaluating cerebral perfusion (CP) or regional cerebral blood flow (rCBF) in adults and children (Hellman et al. 1990; Uvebrant et al. 1991). In neonates, few data are available (Denays et al. 1989; Haddad et al. 1991). In this chapter, we will give an overview of the use of SPECT based on our experience. At the moment we are investigating more than 45 neonates using this technique, mainly for anoxic-ischemic brain injuries.


Single Photon Emission Compute Tomography Cerebral Blood Flow Cerebral Perfusion Single Photon Emission Compute Tomography Imaging Regional Cerebral Blood Flow 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. Haddad
  • A. Constantinesco
  • A. Facello
  • B. Brunot
  • J. Messer

There are no affiliations available

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