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Magnetic Resonance Spectroscopy

  • Chapter
Perinatal Asphyxia

Abstract

In vivo magnetic resonance spectroscopy (MRS) is noninvasive and can obtain metabolic information concerning developmental changes, regulatory functions, and adaptive mechanisms of the human neonatal central nervous system by discerning relevant metabolites from intact cells. Many compounds exist in sufficiently high concentrations in the cytosol of brain cells to be detectable in vivo with modern instrumentation using 31P-, 1H-, or even 13C MRS. Various MRS methods are available which allow both the monitoring of physiological changes in neonatal brain, either during development (Cady et al. 1983, 1991; Younkin et al. 1984; Hamilton et al. 1986; Martin et al. 1988; Boesch et al. 1988, 1989; Azzopardi et al. 1989a; Van der Knaap et al. 1990) or following perinatal injury, by comparing relative metabolite concentrations (Hope et al. 1984; Hamilton et al. 1986; Azzopardi et al. 1989b; Laptook et al. 1989). Some of these techniques have enabled the study of specific areas of the brain under equilibrium conditions (van der Knaap et al. 1990; Moorcraft et al. 1991a) and more recently the estimation of absolute concentrations (Cady and Azzopardi 1989; Cady 1990, 1991), or measuring enzymatic reaction rates, e.g., of the creatine kinase (CK) reaction (Shoubridge et al. 1982; Rudin and Sauter 1989; Mora et al. 1991).

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  1. E. B. Cady
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  2. C. Boesch
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  3. E. Martin
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  1. Service de Néonatologie, Hôpitale Universitaire de Strasbourg, F-67098, Strasbourg Cedex, France

    Joseph Haddad M.D.

  2. Unité 316 INSERM, University Hospital of Tours, 49, Boulevard Béranger, F-37000, Tours, France

    Elie Saliba M.D.

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Cady, E.B., Boesch, C., Martin, E. (1993). Magnetic Resonance Spectroscopy. In: Haddad, J., Saliba, E. (eds) Perinatal Asphyxia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77896-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-77896-4_13

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