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Biochemical Mechanisms of Hypoxic — Ischemic Brain Damage

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Perinatal Asphyxia

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Abstract

Cerebral hypoxia-ischemia remains a major cause of acute perinatal brain injury, leading to severe neurodevelopmental impairments. The incidence of hypoxic—ischemic encephalopathy at birth in full-term infants has been reported to be between two and four per 1000 deliveries in developed countries [3]. Up to 60% of small preterm neonates may suffer brain injury following perinatal asphyxia. In order to understand the therapeutic measures aimed at protecting the brain from hypoxia-ischemia, it is necessary to know the processes involved. In this chapter we will focus on those neurochemical aspects which occur during hypoxia-ischemia and recirculation.

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Authors
  1. E. Saliba
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  2. J. Laugier
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Editor information

Editors and Affiliations

  1. Service de Néonatologie, Hôpitale Universitaire de Strasbourg, F-67098, Strasbourg Cedex, France

    Joseph Haddad M.D.

  2. Unité 316 INSERM, University Hospital of Tours, 49, Boulevard Béranger, F-37000, Tours, France

    Elie Saliba M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Saliba, E., Laugier, J. (1993). Biochemical Mechanisms of Hypoxic — Ischemic Brain Damage. In: Haddad, J., Saliba, E. (eds) Perinatal Asphyxia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77896-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-77896-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77898-8

  • Online ISBN: 978-3-642-77896-4

  • eBook Packages: Springer Book Archive

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