Growth Factor Expression in the Cardiac Myocyte
The processes involved in both normal and abnormal growth of the heart are poorly understood. Enlargement of the heart following haemodynamic overload or as a result of congenital heart disease in both the young and the adult mammal may result from cellular and molecular mechanisms which have common features. Protein growth factors are known to play a critical role in the cycle of normal cell division, differentiation and growth of cells from a variety of organs and tissues. In the heart, their effects on endothelial cells and role in the processes of angiogenesis are the subject of intense interest. However, relatively less is known about the possible role of growth factors in the proliferation and enlargement of the cardiac myocyte. Recent studies, both in vitro and in vivo, suggest that myocytes are the target of selected growth factors, and that they could be implicated in both normal and abnormal hypertrophic growth.
KeywordsSarcoma Polypeptide Cardiomyopathy Acetylcholine Creatine
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