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Growth Factor Expression in the Cardiac Myocyte

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Idiopathic Dilated Cardiomyopathy

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Abstract

The processes involved in both normal and abnormal growth of the heart are poorly understood. Enlargement of the heart following haemodynamic overload or as a result of congenital heart disease in both the young and the adult mammal may result from cellular and molecular mechanisms which have common features. Protein growth factors are known to play a critical role in the cycle of normal cell division, differentiation and growth of cells from a variety of organs and tissues. In the heart, their effects on endothelial cells and role in the processes of angiogenesis are the subject of intense interest. However, relatively less is known about the possible role of growth factors in the proliferation and enlargement of the cardiac myocyte. Recent studies, both in vitro and in vivo, suggest that myocytes are the target of selected growth factors, and that they could be implicated in both normal and abnormal hypertrophic growth.

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Author information

Authors and Affiliations

  1. British Heart Foundation Molecular Cardiology Unit and Senior Lecturer in Physiology, Department of Physiology, The Medical School, University of Birmingham, B15 2TJ, Birmingham, UK

    P. Cummins (Director)

Authors
  1. P. Cummins
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Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Postfach 3742, W-3400, Göttingen, Fed. Rep. of Germany

    Hans-Reiner Figulla

  2. Institut für Pathologie, Universität Tübingen, W-7400, Tübingen, Fed. Rep. of Germany

    Reinhard Kandolf

  3. Max-Planck-Institut für Biochemie, W-8033, Martinsried, Fed. Rep. of Germany

    Reinhard Kandolf

  4. Department of Pathology and Microbiology, University of Nebraska, Medical Center, 600 South 42nd Street, Omaha, NE, 68198-6495, USA

    Bruce McManus Ph.D., M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Cummins, P. (1993). Growth Factor Expression in the Cardiac Myocyte. In: Figulla, HR., Kandolf, R., McManus, B. (eds) Idiopathic Dilated Cardiomyopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77891-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-77891-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77893-3

  • Online ISBN: 978-3-642-77891-9

  • eBook Packages: Springer Book Archive

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