Growth Factor Expression in the Cardiac Myocyte
The processes involved in both normal and abnormal growth of the heart are poorly understood. Enlargement of the heart following haemodynamic overload or as a result of congenital heart disease in both the young and the adult mammal may result from cellular and molecular mechanisms which have common features. Protein growth factors are known to play a critical role in the cycle of normal cell division, differentiation and growth of cells from a variety of organs and tissues. In the heart, their effects on endothelial cells and role in the processes of angiogenesis are the subject of intense interest. However, relatively less is known about the possible role of growth factors in the proliferation and enlargement of the cardiac myocyte. Recent studies, both in vitro and in vivo, suggest that myocytes are the target of selected growth factors, and that they could be implicated in both normal and abnormal hypertrophic growth.
KeywordsFibroblast Growth Factor Cardiac Myocytes Growth Factor Expression Bovine Heart Peptide Growth Factor
Unable to display preview. Download preview PDF.
- 6.Cummins P, Beestone S, Chilton D (1991) Fibroblast growth factor mRNA and protein expression in the developing heart. Eur Heart J 12 [Suppl]:210Google Scholar
- 12.Fiorini JR, Magri KA (1989) Effects of growth factors on myogenic differentiation. AM J Physiol 25:C701-C711Google Scholar
- 17.Liu L, Kardami E (1991) Hypothyroidism favors expression of high molecular weight basic FGF in the heart. J Cell Biochem [Suppl] 15C:171Google Scholar
- 18.Long CS, Kariya K, Karns L, Simpson PC (1990) Trophic factors for cardiac myocytes. J Hypertension 8 [Suppl 7]:S219-S224Google Scholar
- 23.Roberts A, Sporn MB (1990) The transforming growth factor-betas. In: Sporn MB, Roberts AB (eds) Peptide growth factors and their receptors. Springer, Berlin Heidelberg New york, pp 419–472 (Handbook of experimental pharmacology, vol 95, part 1)Google Scholar
- 31.Waterfield MD (ed) (1989) Growth factors. Br Med Bull 45:317–604Google Scholar
- 33.Zak R (1974) Development and proliferative capacity of cardiac muscle cells. Circ Res 34–35 [Supp II]:17–25Google Scholar